Protoporphyrin IX activates the Mg dependent guanylate cyclase from rat liver plasma membranes.

abstract：:Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), but becomes resistant to TKIs after it progresses to blast phase (BP). Here we show that niclosamide, a FDA-approved anthelmintic drug, enhances the sensitivity of BP-CML cells to dasatinib (2nd generation of BCR-ABL TKI) through...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Li Y,Lv C,Wang L,Song H

更新日期：2016-09-16 00:00:00

abstract：:To simultaneously assess the effects of exonic mutations on RNA splicing and protein functions, we report here an intron-inclusive cDNA (Intinc) expression system. As a test model, twenty-four mutations in exon 9 of the phenylalanine hydroxylase (PAH) gene were examined in an Intinc expression plasmid composed of the ...

journal_title：Biochemical and biophysical research communications

authors： Ho PY,Huang MZ,Fwu VT,Lin SC,Hsiao KJ,Su TS

更新日期：2008-09-05 00:00:00

abstract：:The postnatal development and molecular properties of somatostatin receptor were studied in rat cerebral cortex. With [125I-Tyr11]SRIF as a radiolabeled ligand, the specific ligand binding to crude membrane increased transiently in the early phase of postnatal development and then decreased. This increase of somatosta...

journal_title：Biochemical and biophysical research communications

authors： Kimura N

更新日期：1989-04-14 00:00:00

abstract：:Ribonuclease P (RNase P) is an endonuclease responsible for generating the 5(') end of matured tRNA molecules. A homology search of the hyperthermophilic archaeon Pyrococcus horikoshii OT3 genome database revealed that the four genes, PH1481, PH1601, PH1771, and PH1877, have a significant homology to those encoding RN...

journal_title：Biochemical and biophysical research communications

authors： Kouzuma Y,Mizoguchi M,Takagi H,Fukuhara H,Tsukamoto M,Numata T,Kimura M

更新日期：2003-07-04 00:00:00

abstract：:P-glycoprotein (P-gp) is required for adaptive immunity through defined functions in T cell activation and antigen presenting cell (APC) maturation. The potential role of P-gp as an in vivo regulator of alloimmunity is currently unknown. Here we show that P-gp blockade prolongs graft survival in a murine heterotopic c...

journal_title：Biochemical and biophysical research communications

authors： Izawa A,Schatton T,Frank NY,Ueno T,Yamaura K,Pendse SS,Margaryan A,Grimm M,Gasser M,Waaga-Gasser AM,Sayegh MH,Frank MH

更新日期：2010-04-09 00:00:00

abstract：:To repress gene transcription, the unliganded nuclear receptor (NR) recruits the N-CoR and SMRT corepressors via its direct association with the conserved motif within bipartite NR-interaction domains (IDs) of corepressors. We recently reported that SMRT is directly involved in the VDR-mediated repression via an ID1-s...

journal_title：Biochemical and biophysical research communications

authors： Kim JY,Son YL,Lee YC

更新日期：2009-02-13 00:00:00

abstract：:Concanavalin A (ConA), a Ca(2+)/Mn(2+)-dependent and mannose/glucose-binding legume lectin, has drawn a rising attention for its remarkable anti-proliferative and anti-tumor activities to a variety of cancer cells. ConA induces programmed cell death via mitochondria-mediated, P73-Foxo1a-Bim apoptosis and BNIP3-mediate...

journal_title：Biochemical and biophysical research communications

authors： Li WW,Yu JY,Xu HL,Bao JK

更新日期：2011-10-22 00:00:00

abstract：:The C-terminal alpha-amide formation of the peptides is one of the most important events of prohormone processing. We have recently isolated an alpha-amidating enzyme, AE-I, from Xenopus laevis skin, which is the only enzyme ever purified to homogeneity. In this study, we report cloning and sequence of cDNA encoding A...

journal_title：Biochemical and biophysical research communications

authors： Mizuno K,Ohsuye K,Wada Y,Fuchimura K,Tanaka S,Matsuo H

更新日期：1987-10-29 00:00:00

abstract：:Recent evidence suggested that human cardiac stem cells (hCSCs) may have the clinical application for cardiac repair; however, their characteristics and the regulatory mechanisms of their growth have not been fully investigated. Here, we show the novel property of hCSCs with respect to their origin and tissue distribu...

journal_title：Biochemical and biophysical research communications

authors： Tateishi K,Ashihara E,Honsho S,Takehara N,Nomura T,Takahashi T,Ueyama T,Yamagishi M,Yaku H,Matsubara H,Oh H

更新日期：2007-01-19 00:00:00

abstract：:Farnesylation of p21Ras is required for translocation to the plasma membrane and subsequent activation by growth factors. Previously we demonstrated that insulin stimulates the phosphorylation of farnesyltransferase (FTase) and its activity, whereby the amount of farnesylated p21Ras anchored at the plasma membrane is ...

journal_title：Biochemical and biophysical research communications

authors： Solomon CS,Goalstone ML

更新日期：2001-07-13 00:00:00

abstract：:Heme is central to oxygen sensing and utilization in all living organisms. It directly regulates numerous molecular and cellular processes for systems that sense or use oxygen. In mammals, heme plays an indispensable role in erythroid cell differentiation. To investigate heme regulatory functions, we identified, by di...

journal_title：Biochemical and biophysical research communications

authors： Zhu Y,Hon T,Zhang L

更新日期：1999-04-29 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is featured by hepatic steatosis, insulin resistance, lipid deposition and inflammation. However, the pathogenic mechanism of NAFLD is still poorly understood. Dual-specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, has been reported to negativ...

journal_title：Biochemical and biophysical research communications

authors： Wu YK,Hu LF,Lou DS,Wang BC,Tan J

更新日期：2020-03-26 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis and its activation during T cell receptor stimulation has recently been reported. In this study, we examined the role of AMPK in interleukin (IL)-2 production in T cells. Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small...

journal_title：Biochemical and biophysical research communications

authors： Jhun BS,Lee JY,Oh YT,Lee JH,Choe W,Baik HH,Kim SS,Yoon KS,Ha J,Kang I

更新日期：2006-12-29 00:00:00

abstract：:The organization of caveolae ultrastructures in the plasma membrane and the functions they dictate are mediated by membrane-embedded caveolins (caveolin-1, 2, 3) and peripherally attached cavins (cavin-1, 2, 3, 4). Mutations in caveolin and cavin genes are associated with a variety of human diseases. Cavin-1/PTRF muta...

journal_title：Biochemical and biophysical research communications

authors： Mohapatra A,Lokappa SB,Chaudhary N

更新日期：2020-01-15 00:00:00

abstract：:Incubation of rabbit aortic endothelial cells (RAEC) with oxidized low-density lipoprotein (LDL) for 16 h resulted in stimulation of calcium uptake and increased release of nitric oxide (NO) by these cells. Accompanying inhibition of protein tyrosine phosphatase (PTP) activity in these cells was also observed. Convers...

journal_title：Biochemical and biophysical research communications

authors： Fries DM,Penha RG,D'Amico EA,Abdalla DS,Monteiro HP

更新日期：1995-02-06 00:00:00

abstract：:Deficiency in the enzyme adenosine deaminase (ADA) in humans manifests primarily as severe lymphopenia and immunodeficiency, resulting in death by 6 months of age, if untreated. In this review, we discuss phenotypical, biochemical, and metabolic hallmarks of the disease, and describe a mouse model in which levels of A...

journal_title：Biochemical and biophysical research communications

authors： Aldrich MB,Blackburn MR,Kellems RE

更新日期：2000-06-07 00:00:00

abstract：:Biochemical properties of Type II restriction enzyme BanI were characterized. Kinetic parameters were evaluated and an enhancement of rate was observed when the recognition site was located in a more central position in the substrate, suggesting that BanI locates its recognition site by a sliding mechanism. As BanI ha...

journal_title：Biochemical and biophysical research communications

authors： Advani S,Roy KB

更新日期：2000-12-09 00:00:00

abstract：:In a gene chip analysis of common pituitary tumor types, one of the genes with the most impressive tissue-specific expression regulation was delta-like 1 (DLK1), which was strongly expressed in GH-secreting (GH-S) pituitary tumors. In addition to pituitary adenomas, various endocrine tumors were subjected to real-time...

journal_title：Biochemical and biophysical research communications

authors： Altenberger T,Bilban M,Auer M,Knosp E,Wolfsberger S,Gartner W,Mineva I,Zielinski C,Wagner L,Luger A

更新日期：2006-02-17 00:00:00

abstract：:TonEBP/NFAT5 transcription factor is a master regulator of genes involved in osmoprotection. Cyclooxygenase 2 (COX2) has been reported to be a cytoprotective molecule in the inner renal medulla, where cells are physiologically exposed to the highest osmolality of the body. Our aim was to study whether COX2 expression ...

journal_title：Biochemical and biophysical research communications

authors： Favale NO,Casali CI,Lepera LG,Pescio LG,Fernández-Tome MC

更新日期：2009-04-10 00:00:00

abstract：:Trichosanthin is a ribosome-inactivating protein that possesses antitumor and antiviral activities. Clinical trials of trichosanthin on AIDS patients, however, elicit anaphylactic reactions. To reduce the antigenicity of trichosanthin as a drug while preserving its biological activity, the C-terminal domain (residues ...

journal_title：Biochemical and biophysical research communications

authors： Chan SH,Shaw PC,Mulot SF,Xu LH,Chan WL,Tam SC,Wong KB

更新日期：2000-04-02 00:00:00

abstract：:This report describes the in vivo phosphorylation of isocitrate lyase and examines the possible consequences to the control of the Kreb's cycle and glyoxylate bypass. NADP-specific isocitrate dehydrogenase from E. coli was the first bacterial protein whose enzymic activity was shown to be modulated by reversible phosp...

journal_title：Biochemical and biophysical research communications

authors： Hoyt JC,Reeves HC

更新日期：1988-06-16 00:00:00

abstract：:The marked impairment of hepatic drug metabolism during inflammation and infections has been known for many years and shown to result from down-regulation of cytochrome P450s (CYP) by cytokines. However, the mechanism of this repression is unknown. Using primary cultures of human hepatocytes, we show here that interle...

journal_title：Biochemical and biophysical research communications

authors： Pascussi JM,Gerbal-Chaloin S,Pichard-Garcia L,Daujat M,Fabre JM,Maurel P,Vilarem MJ

更新日期：2000-08-11 00:00:00

abstract：:The cell-specific cytosolic delivery of functional macromolecules with high efficiency is of great significance in molecular medicine and biotechnology. Herein, we present a Shiga-like toxin II-based high-efficiency and receptor-specific intracellular delivery system. We designed and constructed the Shiga-like toxin-b...

journal_title：Biochemical and biophysical research communications

authors： Ryou JH,Sohn YK,Hwang DE,Kim HS

更新日期：2015-09-04 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are a crucial member of the non-coding RNA family, and increasing evidence demonstrates that lncRNAs participate in the initiation and progression of cancers. Our study aimed to explore the role of the lncRNA LINC00165 in gastric cancer (GC) development. In the present study, our results...

journal_title：Biochemical and biophysical research communications

authors： Jin Y,Wu P,Zhao W,Wang X,Yang J,Huo X,Chen J,De W,Yang F

更新日期：2018-12-09 00:00:00

abstract：:The small heat shock proteins are the ubiquitous proteins found in a wide range of organisms and function as molecular chaperones by binding to the folding intermediates of their substrates. Although the crystal structure of HSP16.5, a small heat shock protein from Methanococcus jannaschii, revealed that it is a hollo...

journal_title：Biochemical and biophysical research communications

authors： Kim DR,Lee I,Ha SC,Kim KK

更新日期：2003-08-08 00:00:00

abstract：:Recombinant acquorin is widely used as an intracellular Ca2+ indicator within live cells. Our data shows that recombinant apoacquorin was unstable within the cytosol, with a half life of approximately 20 minutes. Targeting of the protein to subcellular organelles resulted in an increase in stability which may be due t...

journal_title：Biochemical and biophysical research communications

authors： Badminton MN,Sala-Newby GB,Kendall JM,Campbell AK

更新日期：1995-12-26 00:00:00

abstract：:Fluid flowing through the bone porosity might be a primary stimulus for functional adaptation of bone. Osteoblasts, and osteocytes in particular, respond to fluid flow in vitro with enhanced nitric oxide (NO) and prostaglandin E(2) (PGE(2)) release; both of these signaling molecules mediate mechanically-induced bone f...

journal_title：Biochemical and biophysical research communications

authors： McGarry JG,Klein-Nulend J,Prendergast PJ

更新日期：2005-04-29 00:00:00

abstract：:Heat shock cognate protein 70 (HSC70) has been shown to bind to the peptide corresponding to amino acids 197 to 216 of human T-cell lymphotropic virus type I (HTLV-I) envelope protein, gp46, and an anti-HSC70 monoclonal antibody (mAb) inhibits HTLV-I-induced syncytium formation. These findings suggest that HSC70 is ne...

journal_title：Biochemical and biophysical research communications

authors： Fang D,Haraguchi Y,Jinno A,Soda Y,Shimizu N,Hoshino H

更新日期：1999-08-02 00:00:00

abstract：:Small interfering RNAs (siRNAs) have become the most powerful and widely used gene silencing reagents for reverse functional genomics and molecular therapeutics. The key challenge for achieving effective gene silencing in particular for the purpose of the therapeutics is primarily dependent on the effectiveness and sp...

journal_title：Biochemical and biophysical research communications

authors： Hung CF,Lu KC,Cheng TL,Wu RH,Huang LY,Teng CF,Chang WT

更新日期：2006-08-04 00:00:00

abstract：:Activities of three kinases, phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP), and diacylglycerol (DG) kinases, and phospholipase C were measured in erythrocyte ghosts from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). PI kinase activity was significantly higher in SH...

journal_title：Biochemical and biophysical research communications

authors： Kato H,Takenawa T

更新日期：1987-08-14 00:00:00