The effect of parasitization by Leishmania mexicana mexicana on macrophage function in vitro.

Abstract:

:Macrophages infected with amastigotes of Leishmania mexicana mexicana as compared to normal macrophages show decreased migration both randomly and through a 5 microns pore in response to a known chemotaxin, an increased ability to pinocytose and an increased bactericidal ability. Unless very heavily parasitized their ability to phagocytose is unaltered. Parasitized macrophages are unaltered in their ability to secrete extracellularly lysosomal enzymes, prostaglandins and lysozyme in response to known stimuli, or to kill target cells in an antibody dependent cell mediated cytotoxicity assay.

journal_name

Acta Trop

journal_title

Acta tropica

authors

Bray RS,Heikal B,Kaye PM,Bray MA

subject

Has Abstract

pub_date

1983-03-01 00:00:00

pages

29-38

issue

1

eissn

0001-706X

issn

1873-6254

journal_volume

40

pub_type

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