Development and sexual maturation of Echinococcus granulosus adult worms in the alternative definitive host, Mongolian gerbil (Meriones unguiculatus).


:In the present study for the first time an alternative definitive host model has been established for the complete development of Echinococcus granulosus in Meriones unguiculatus (Mongolian gerbils) up to shelled eggs production, as happened in the natural host. Animals treated with methylprednisolone acetate were orally inoculated with approximately 3000 protoscoleces and the development of parasites in the small intestine observed up to 46 days post-infection (p.i.). The cestodes survive, strobilate, mature sexually and complete their development in the intestine up to production of shelled embryonated eggs containing fully formed six-hooked oncospheres, similarly to the natural canid host (stage 7 by Smyth). Shelled eggs are first observed in the rodent/E. granulosus model at 44 days p.i. Somatic growth in gerbils appears to follow a similar trend to dogs, length increasing to over 3mm at 44 days p.i., while, compared to the natural host, organogenesis is observed only to progress at a slower rate in the early developmental stages. Parasite burden was found to vary among non-inbred animals and developmental stages of worms recovered from the same animal differed widely. Worm localisation follows the pattern observed in the natural host, the parasites appearing for the most part distributed in the proximal third of the small intestine. The development of alternative definitive hosts may facilitate research in this field, overcoming legislative impediments that restrict the use of dogs for experimental purposes.


Acta Trop


Acta tropica


Conchedda M,Gabriele F,Bortoletti G




Has Abstract


2006-02-01 00:00:00














  • Trypanosoma congolense: re-expression of a deleted metacyclic variable antigen type in vivo and in vitro.

    abstract::The expression of variable antigen types (VATs) was determined among dividing populations of T. congolense growing in vivo in rabbit chancres and in vitro on bovine aorta endothelial cell monolayers. Experiments were performed in which a single metacyclic VAT (M-VAT) was deleted from a cultured metacyclic population b...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Sutherland DV,Ross CA,Luckins AG

    更新日期:1991-08-01 00:00:00

  • Therapeutic failure of primaquine and need for new medicines in radical cure of Plasmodium vivax.

    abstract::Primaquine has been the drug of choice for the prevention of Plasmodium vivax relapse for more than 60 years. Primaquine tolerant strain of P. vivax was identified in 1944. Significant mortality and disease burden of P. vivax calls for the need of new drugs. Primaquine resistance is a complex issue, as the mechanism o...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Thomas D,Tazerouni H,Sundararaj KG,Cooper JC

    更新日期:2016-08-01 00:00:00

  • Update on the status of leptospirosis in New Zealand.

    abstract::Leptospirosis is a zoonotic disease that poses public health and ecological threats worldwide. In New Zealand (NZ), incidence of the disease is relatively high compared to other developed countries. The aim of this review was to describe the epidemiological status, ecological risk of leptospirosis and prevention in NZ...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: El-Tras WF,Bruce M,Holt HR,Eltholth MM,Merien F

    更新日期:2018-12-01 00:00:00

  • Kerteszia Theobald (Diptera: Culicidae) mosquitoes and bromeliads: A landscape ecology approach regarding two species in the Atlantic rainforest.

    abstract::On the ecological scale of an organism, a homogeneous geographical landscape can represent a mosaic of heterogeneous landscapes. The bionomy of Kerteszia mosquitoes can contribute to foundation landscape ecology by virtue of in the role of the configuration and composition of the habitat played in the distribution of ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Chaves LSM,Rodrigues de Sá IL,Bergamaschi DP,Sallum MAM

    更新日期:2016-12-01 00:00:00

  • Mechanoreceptor--trypanosome interactions in the labrum of Glossina: fluid mechanics.

    abstract::The fluid mechanics of the flow of blood through the labrum of Glossina is described in uninfected and trypanosome infected flies. The flow is characterised by the Reynolds number, and a frequency parameter for the pulsating flow and non-newtonian viscosity effects are considered. The effects of colonies of trypanosom...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Livesey JL,Molyneux DH,Jenni L

    更新日期:1980-06-01 00:00:00

  • Magnetic affinity enzyme-linked immunoassay based on recombinant 26 kDa glutathione-S-transferase for serological diagnosis of schistosomiasis japonica.

    abstract::Schistosomiasis remains a serious worldwide public health problem. Improving the diagnostic assay for surveillance and monitoring will contribute to hastening the possible elimination of the disease in endemic regions. Therefore, this study aims to develop magnetic affinity enzyme-linked immunoassay (MEIA) for serolog...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Yu Q,Yang H,Feng Y,Yang X,Zhu Y

    更新日期:2012-12-01 00:00:00

  • Modeling Dengue vector population using remotely sensed data and machine learning.

    abstract::Mosquitoes are vectors of many human diseases. In particular, Aedes ægypti (Linnaeus) is the main vector for Chikungunya, Dengue, and Zika viruses in Latin America and it represents a global threat. Public health policies that aim at combating this vector require dependable and timely information, which is usually exp...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Scavuzzo JM,Trucco F,Espinosa M,Tauro CB,Abril M,Scavuzzo CM,Frery AC

    更新日期:2018-09-01 00:00:00

  • Characterization of the metacaspase 1 gene in Plasmodium vivax field isolates from southern Iran and Italian imported cases.

    abstract::Plasmodium vivax is still the more prevalent human Plasmodium outside Africa and despite this fact, there is still a deep lack of knowledge on its biology. Metacaspases are cysteine proteases related to metazoan caspases, involved in programmed cell death. Here, we have characterized the P. vivax metacaspase 1 gene in...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Rezanezhad H,Menegon M,Sarkari B,Hatam GR,Severini C

    更新日期:2011-07-01 00:00:00

  • Chemical composition of Litomosoides carinii microfilarial sheaths.

    abstract::Litomosoides carinii microfilariae were exsheathed by freezing and thawing, and the sheaths were separated by filtration. Samples of pure sheaths thus obtained were hydrolyzed, methanolyzed or oxidized with nitric acid under pressure at 300 degrees C, respectively, and were analyzed for amino acids, sugars, fatty acid...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Bardehle G,Jepp-Libutzki A,Linder D,Moehnle K,Schott HH,Zahner H,Zähringer U,Stirm S

    更新日期:1992-02-01 00:00:00

  • Seroprevalence and risk factors of human cysticercosis and taeniasis prevalence in a highly endemic area of epilepsy in Bangoua, west Cameroon.

    abstract::Cysticercosis caused by the larvae of Taenia solium is a serious and emerging threat to public health in the endemic areas as well as in the non-endemic areas. Neurocysticercosis, an affection of the central nervous system is a leading cause of epilepsy in endemic areas. This study was carried out to investigate human...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Nkouawa A,Dschanou AR,Moyou-Somo R,Sako Y,Ito A

    更新日期:2017-01-01 00:00:00

  • Governance, organization, accountability and sustainability of a region-wide school-based deworming program in Loreto, Peru.

    abstract::Chau Cuica was the name given by the regional government of Loreto in Peru for its school-based deworming program which was initiated in 2012 with a donation of mebendazole from an international non-governmental organization. Embedded in the program from the start was a sentinel surveillance component which consisted ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Ferruci HR,Razuri H,Casapia M,Rahme E,Silva H,Ault S,Blouin B,Mofid LS,Montresor A,Gyorkos TW

    更新日期:2016-07-01 00:00:00

  • Naturally acquired immune responses to thrombospondin-related adhesion protein (TRAP) of Plasmodium vivax in patients from areas of unstable malaria transmission.

    abstract::A key tool for the control, elimination, and eradication of Plasmodium vivax is the development of an effective vaccine. The thrombospondin-related adhesion protein (TRAP) is one of the major sporozoite antigens that plays an important role in the invasion of mosquito salivary glands and hepatocytes by sporozoites. Th...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Nazeri S,Zakeri S,Mehrizi AA,Djadid ND

    更新日期:2017-09-01 00:00:00

  • Morphological study of anomalous "laminated" brood capsules in cystic echinococcosis in humans and sheep.

    abstract::"Anomalous", as yet unreported forms of brood capsules (BC) in cystic echinococcosis larvae from humans and sheep are described, thought to be the likely effect of degenerative involution of the parasite. Morphological examination showed an inner laminated layer (LL) in the brood capsules in intimate contact with the ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Conchedda M,Gabriele F,Bortoletti G

    更新日期:2008-03-01 00:00:00

  • Host use and seasonality of Culex (Melanoconion) iolambdis (Diptera: Culicidae) from eastern Florida, USA.

    abstract::Culex (Melanoconion) iolambdis (Dyar, 1918) is a mosquito (Diptera: Culicidae) species found throughout much of tropical America, including southern Florida. Relatively few reports are available regarding the ecology of Cx. iolambdis, despite its widespread distribution and putative involvement in transmission of Vene...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Blosser EM,Stenn T,Acevedo C,Burkett-Cadena ND

    更新日期:2016-12-01 00:00:00

  • Influence of fever and flurbiprofen on trypanosome growth.

    abstract::The administration of flurbiprofen, a potent non-steroidal anti-inflammatory drug (NSAID), to goats infected with trypanosomes resulted in high elevated parasitaemia and suppression of fever. In contrast to goats, rats infected with trypanosomes do not show febrile reactions. Therefore, the role of body temperature wa...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Zwart D,Brun R,Dwinger RH,van Miert AS,Franssen FF,Nieuwenhuijs J,Kooy RF

    更新日期:1990-02-01 00:00:00

  • Stormwater drains and catch basins as sources for production of Aedes aegypti and Culex quinquefasciatus.

    abstract::We present data showing that structures serving as drains and catch basins for stormwater are important sources for production of the mosquito arbovirus vectors Aedes aegypti and Culex quinquefasciatus in Mérida City, México. We examined 1761 stormwater drains - located in 45 different neighborhoods spread across the ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Arana-Guardia R,Baak-Baak CM,Loroño-Pino MA,Machain-Williams C,Beaty BJ,Eisen L,García-Rejón JE

    更新日期:2014-06-01 00:00:00

  • Progress in research, control and elimination of helminth infections in Asia.

    abstract::Global health has substantially improved over the past 20 years. In low- and middle-income countries, in particular, great strives have been made in the control of communicable diseases, including helminth infections. Nevertheless, the most marginalised communities still suffer from infectious diseases that are intima...

    journal_title:Acta tropica

    pub_type: 社论


    authors: Utzinger J,Brattig NW,Leonardo L,Zhou XN,Bergquist R

    更新日期:2015-01-01 00:00:00

  • Differentiation of Trypanosoma cruzi, T. cruzi marinkellei, T. dionisii and T. vespertilionis by monoclonal antibodies.

    abstract::Anti-T. dionisii and anti-T. vespertilionis monoclonal antibodies secreted by 17 hybridoma clones were tested against various strains of T. dionisii, T. vespertilionis, T. cruzi and T. cruzi marinkellei. Strain and species specific antigens were detected for the homologous immunizing strains. The common antigenic dete...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Petry K,Baltz T,Schottelius J

    更新日期:1986-03-01 00:00:00

  • Advantages of bioconjugated silica-coated nanoparticles as an innovative diagnosis for human toxoplasmosis.

    abstract::Nanotechnology is a promising arena for generating new applications in Medicine. To successfully functionalised nanoparticles for a given biomedical application, a wide range of chemical, physical and biological factors have to be taken into account. Silica-coated nanoparticles, (SiO2NP) exhibit substantial diagnostic...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Aly I,Taher EE,El Nain G,El Sayed H,Mohammed FA,Hamad RS,Bayoumy EM

    更新日期:2018-01-01 00:00:00

  • Sarconesiopsis magellanica (Diptera: Calliphoridae) excretions and secretions have potent antibacterial activity.

    abstract::The most important mechanism for combating infection using larval therapy depends on larval excretions and secretions (ES). The present work was aimed at evaluating Sarconesiopsis magellanica (Diptera: Calliphoridae) ES antibacterial activity in six bacterial strains (three Gram-positive and three Gram-negative) and c...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Díaz-Roa A,Gaona MA,Segura NA,Suárez D,Patarroyo MA,Bello FJ

    更新日期:2014-08-01 00:00:00

  • Sequence analysis in partial genes of five isolates of Angiostrongylus cantonensis from Taiwan and biological comparison in infectivity and pathogenicity between two strains.

    abstract::Angiostrongylus cantonensis is the most common infectious agent causing eosinophilic meningitis and is present in Taiwan, Thailand and the Pacific islands. Clinical symptoms vary within different endemic regions, and their severity is probably dependent on the number of ingested parasites and the diversity among strai...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Lee JD,Chung LY,Wang LC,Lin RJ,Wang JJ,Tu HP,Wu ZD,Yen CM

    更新日期:2014-05-01 00:00:00

  • Homidium bromide as a chemoprophylactic for cattle trypanosomiasis in Kenya.

    abstract::Homidium bromide was used in a strategic chemoprophylactic regime to control trypanosomiasis in Boran cattle in Kenya. Trypanosome infection rates in cattle receiving homidium bromide prophylaxis were compared with those in control cattle which received no prophylaxis but were treated with diminazene aceturate when in...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Dolan RB,Okech G,Alushula H,Mutugi M,Stevenson P,Sayer PD,Njogu AR

    更新日期:1990-03-01 00:00:00

  • Towards elimination of schistosomiasis after 5000 years of endemicity in Egypt.

    abstract::Schistosomiasis is a snail-transmitted infectious disease caused by a long lasting infection with a blood fluke of the genus Schistosoma. S. haematobium and S. mansoni are the species endemic in Egypt. The country has been plagued and seriously suffered from schistosomiasis over the past 5000 years. Great strides had ...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Abou-El-Naga IF

    更新日期:2018-05-01 00:00:00

  • Identification of antigenically distinct populations of Leishmania (Viannia) guyanensis from Manaus, Brazil, using monoclonal antibodies.

    abstract::Eighty Leishmania isolates from patients who contracted cutaneous leishmaniasis in the Manaus region, Amazonas State, Brazil, were identified as Leishmania (Viannia) guyanensis by the electrophoretic profiles of six enzymes. None reacted with the species-specific monoclonal antibody B19. Two L. (V.) guyanensis subpopu...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Romero GA,Ishikawa E,Cupolillo E,Toaldo CB,Guerra MV,Paes MG,Macêdo Vde O,Shaw JJ

    更新日期:2002-04-01 00:00:00

  • Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission.

    abstract::Triatoma infestans is a mandatory haematophagous vector of Chagas disease in Brazil. Despite a large number of studies on the anti-haemostatic molecules present in its saliva, the role of its salivary components on parasite transmission is poorly understood. Here, we show that the bioactive lipid molecule, lysophospha...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Lima MS,Carneiro AB,Souto-Padron T,Jurberg J,Silva-Neto MAC,Atella GC

    更新日期:2018-02-01 00:00:00

  • Epidemiology of human leptospirosis in Malaysia, 2004-2012.

    abstract::Leptospirosis is an emerging disease, especially in countries with a tropical climate such as Malaysia. A dramatic increase in the number of cases has been reported over the last decade; however, information on the epidemiological trends of this disease is lacking. The objective of this study is to provide an epidemio...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Benacer D,Thong KL,Min NC,Bin Verasahib K,Galloway RL,Hartskeerl RA,Souris M,Mohd Zain SN

    更新日期:2016-05-01 00:00:00

  • Anaplasmataceae, Borrelia and Hepatozoon agents in ticks (Acari: Argasidae, Ixodidae) from Chile.

    abstract::Microorganisms harbored by Chilean autochthonous ticks have been scarcely studied and current knowledge is restricted to three species of hard ticks only. The current study aimed to assess the presence of Anaplasmataceae, Borrelia and Hepatozoon agents in ticks collected directly from the environment, on reptiles, bir...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Muñoz-Leal S,Lopes MG,Marcili A,Martins TF,González-Acuña D,Labruna MB

    更新日期:2019-04-01 00:00:00

  • Prevalence of different trypanosomes in livestock in Blue Nile and West Kordofan States, Sudan.

    abstract::African animal trypanosomosis, transmitted cyclically by tsetse flies or mechanically by other biting flies, causes serious health problems in livestock. Although tsetse infestations have been observed in Blue Nile State in Sudan, tsetse was eradicated in West Kordofan in 1962, and no further studies have been carried...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Mossaad E,Ismail AA,Ibrahim AM,Musinguzi P,Angara TEE,Xuan X,Inoue N,Suganuma K

    更新日期:2020-03-01 00:00:00

  • Minimal efficacy requirements for malarial vaccines to significantly lower transmission in epidemic or seasonal malaria.

    abstract::The effect of vaccines against the pre-erythrocytic, the erythrocytic and the sexual stages of malaria on the transmission of malaria was examined using a simulation model of seasonal or epidemic transmission. The primary outcome of the model was the number of cases of malaria present at the end of the transmission se...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Saul A

    更新日期:1993-01-01 00:00:00

  • Role of proteases in host cell invasion by Toxoplasma gondii and other Apicomplexa.

    abstract::The process of invasion by apicomplexan parasites is a carefully coordinated process involving the regulated release of specialized secretory organelles. Several lines of evidence suggest that proteases are critical for the assembly and trafficking of organellar content proteins. Further, invasion is accompanied by cl...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Kim K

    更新日期:2004-06-01 00:00:00