Abstract：
:Schistosomiasis is a neglected disease caused by helminth flatworms of the genus Schistosoma, affecting over 240 million people in more than 70 countries. The treatment relies on a single drug, praziquantel, making urgent the discovery of new compounds. Aurones are a natural type of flavonoids that display interesting pharmacological activities, particularly as chemotherapeutic agents against parasites. In pursuit of treatment alternatives, the present work conducted an in vitro and in vivo antischistosomal investigation with aurone derivatives against Schistosoma mansoni. After preparation of aurone derivatives and their in vitro evaluation on adult schistosomes, the three most active aurones were evaluated in cytotoxicity and haemolytic assays, as well as in confocal laser-scanning microscope studies, showing tegumental damage in parasites in a concentration-dependent manner with no haemolytic or cytotoxic potential toward mammalian cells. In a mouse model of schistosomiasis, at a single oral dose of 400 mg/kg, the selected aurones showed worm burden reductions of 35% to 65.0% and egg reductions of 25% to 70.0%. The most active thiophenyl aurone derivative 18, unlike PZQ, had efficacy in mice harboring juvenile S. mansoni, also showing significant inhibition of oviposition by parasites, giving support for the antiparasitic potential of aurones as lead compounds for novel antischistosomal drugs.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Pereira VRD,da Silveira LS,Mengarda AC,Alves Júnior IJ,da Silva OOZ,Miguel FB,Silva MP,Almeida ADC,Torres DDS,Pinto PF,Coimbra ES,de Moraes J,Couri MRC,da Silva Filho AAdoi
10.1016/j.actatropica.2020.105741subject
Has Abstractpub_date
2021-01-01 00:00:00pages
105741eissn
0001-706Xissn
1873-6254pii
S0001-706X(20)31654-5journal_volume
213pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract：:In dogs, information on treatments against S. stercoralis infection is rare and anecdotal. The aim of the present work was to evaluate the treatment outcome of S. stercoralis natural infection in sheltered dogs. Furthermore, based on the potential risk of infection, people working in the infected shelter were also tes...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.11.014
更新日期：2019-02-01 00:00:00
abstract：:Studies on in vitro skin permeation and in vivo anti-leishmanial activity in mice experimentally infected with Leishmania (Leishmania) major pointed out to the potential of a new paromomycin (PA) formulation (hydrophilic gel) for treatment of cutaneous leishmaniasis (CL). In this study, the activity of this formulatio...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2004.10.007
更新日期：2005-02-01 00:00:00
abstract：:Triatoma infestans is a mandatory haematophagous vector of Chagas disease in Brazil. Despite a large number of studies on the anti-haemostatic molecules present in its saliva, the role of its salivary components on parasite transmission is poorly understood. Here, we show that the bioactive lipid molecule, lysophospha...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.10.022
更新日期：2018-02-01 00:00:00
abstract：:Echinococcosis, a disease caused by infection with the larval stage of a tapeworm parasite of the genus Echinococcus, is of major socio-economic importance, and studying genetic variability within and between Echinococcus populations has important implications for disease control and epidemiology. Various DNA approach...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(98)00052-7
更新日期：1998-09-15 00:00:00
abstract：:The parasitological techniques currently in use for the diagnosis of African trypanosomiasis were compared in a series of experiments for their capacity to detect Trypanosoma congolense, T. vivax and T. brucei in the blood of cattle. The darkground/phase contrast buffy coat method proved to be more sensitive than the ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1982-12-01 00:00:00
abstract：:Disease control programmes are an intrinsic part of health systems. Neglected tropical disease (NTD) control is a clear case in point. While there is a growing consensus that NTD control and health services are linked, with important mutual impacts, little is known of what actually happens at the interface between the...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2011.02.017
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Visceral leishmaniasis (VL) affecting HIV-infected patients is considered a challenging condition because of its high mortality and relapse rates. The approach of this condition is still surrounded by many uncertainties, especially regarding the criteria to institute and discontinue secondary prophylaxis for...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.05.011
更新日期：2017-08-01 00:00:00
abstract：:The aim of the study was to evaluate the temporal patterns of dengue incidence from 2001 to 2014 and forecast for 2015 in two Brazilian cities. We analysed dengue surveillance data (SINAN) from Recife, 1.6 million population, and Goiania, 1.4 million population. We used Auto-Regressive Integrated Moving Average (ARIMA...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.03.006
更新日期：2018-06-01 00:00:00
abstract：:Toxoplasmosis is a common and serious parasitic disease with high prevalence and global distribution in human and other warm-blooded vertebrates. Though the infection of Toxoplasma gondii is usually asymptomatic in healthy people, it can lead to severe pathological effects to the fetus of infected women and immunocomp...
journal_title：Acta tropica
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.actatropica.2016.03.003
更新日期：2016-06-01 00:00:00
abstract：:Over the last 20 years a great advance has been observed in many aspects of medicine, and the advent of novel imaging techniques is certainly amongst the most important. In schistosomiasis these new methods caused a revolution in the definition of the clinical forms of the disease and in the evaluation of its complica...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2008.07.009
更新日期：2008-11-01 00:00:00
abstract：:Sound and its reception are crucial for reproduction, survival, and population maintenance of many animals. In insects, low-frequency vibrations facilitate sexual interactions, whereas noise disrupts the perception of signals from conspecifics and hosts. Despite evidence that mosquitoes respond to sound frequencies be...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.03.027
更新日期：2019-06-01 00:00:00
abstract：:A large-scale control trial against Glossina palpalis palpalis was carried out in the Congo using a new trapping technique. In the same way a test related to the experimental utilization of sentinel animals was performed, concurrently to the classical epidemiological and entomological evaluation. 564 domestic animals ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：:Personal protection measures have become an important tool against mosquito nuisance. The severity of mosquito nuisance and the type and costs of personal protection measures in the Pondicherry region in South India have been investigated, using a structured questionnaire. The number of respondents sampled was 300 in ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(03)00155-4
更新日期：2003-09-01 00:00:00
abstract：:Microorganisms harbored by Chilean autochthonous ticks have been scarcely studied and current knowledge is restricted to three species of hard ticks only. The current study aimed to assess the presence of Anaplasmataceae, Borrelia and Hepatozoon agents in ticks collected directly from the environment, on reptiles, bir...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.02.002
更新日期：2019-04-01 00:00:00
abstract：:Ten species of Aeromonas have been previously identified in farmed rainbow trout from Mexico. The aim of the current study was to investigate the pathogenicity of 10 Aeromonas isolates belonging to 10 different Aeromonas species in immersion experimentally-infected rainbow trout fry. Isolates of A. bestiarum, A. hydro...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.02.013
更新日期：2017-05-01 00:00:00
abstract：:Leptospirosis, a disease that occurs worldwide, especially in tropical regions, is caused by bacteria of the genus Leptospira and affects mammals, amphibians, and reptiles. Boa constrictor snakes are commonly found in Atlantic rainforest fragments in peri‑urban areas, which indicates a greater possibility of the conta...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105572
更新日期：2020-09-01 00:00:00
abstract：:Extracts prepared from 15 rare Tanzanian medicinal plants were tested for their in vitro antitrypanosomal activity against human pathogenic trypanosomes (Trypanosoma brucei rhodesiense). Of 37 extracts investigated, two were found to have strong activity with IC50 values below 1 microgram/ml and ten extracts revealed ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00034-x
更新日期：1997-08-01 00:00:00
abstract：INTRODUCTION:This article reports, for the first time, the occurrence of Panstrongylus megistus in the Brazilian Western Amazon. METHODS:Specimens of P. megistus were collected in the cities of Rio Branco, Acre and Extrema, Rondônia. RESULTS:The number of triatomine species in the State of Acre increased from eight t...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.02.032
更新日期：2018-06-01 00:00:00
abstract：:Four strains of Trypanosoma cruzi (Y, BG, M and Peru) retain their ability to infect Rhodnius prolixus and to produce virulent infections in mice for from 12 to 39 years. About 60 or more metacyclic trypomastigotes were consistently lethal to mice. The mean number of metacyclics per bug ranged from 1.2 to 17.3 x 10(3)...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:Leishmaniasis, a zoonotic disease caused by parasites of the genus Leishmania, has expanded beyond its natural range and is becoming increasingly urban. Using PCR and PCR-RFLP, we detected Leishmania (Viannia) braziliensis in two bats (Chiroptera) in Mato Grosso do Sul, Brazil, an endemic area. This is the first recor...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2013.07.004
更新日期：2013-10-01 00:00:00
abstract：:In developing countries, smallholder poultry production contributes to food security and poverty alleviation in rural areas. However, traditional poultry marketing chains have been threatened by the epidemics caused by the Highly Pathogenic Avian Influenza (H5N1) virus. The article presents a value chain analysis cond...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2013.01.008
更新日期：2013-04-01 00:00:00
abstract：:In the presence of light and oxygen, rose bengal causes oxidative damage to Trypanosoma cruzi. The production of lipid hydroperoxides was demonstrated by thin-layer chromatography, and severe ultrastructural alterations compatible with an increased permeability of the cells, which led to gradual osmotic swelling and u...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：BACKGROUND:To better understand the epidemiology of tick-borne disease in Mongolia, a comprehensive seroprevalence study was conducted investigating exposure to Anaplasma spp. and spotted fever group (SFG) Rickettsia spp. in nomadic herders and their livestock across three provinces from 2014 to 2015. METHODS:Blood wa...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.10.015
更新日期：2018-01-01 00:00:00
abstract：:The salivary glands of insect's vectors are target organs to study the vectors-pathogens interactions. Rhodnius prolixus an important vector of Trypanosoma cruzi can also transmit Trypanosoma rangeli by bite. In the present study we have investigated ecto-phosphatase activity on the surface of R. prolixus salivary gla...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.02.008
更新日期：2008-05-01 00:00:00
abstract：:The aim of this study is to investigate the feasibility and outcomes of using Gravid Oviposition Sticky (GOS) trap and dengue NS1 antigen tests for indoor and outdoor dengue/Aedes surveillance in the field. A one-year community-based study was carried out at Sungai Buloh Hospital Quarters, Selangor, Malaysia. GOS trap...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2021.105829
更新日期：2021-01-16 00:00:00
abstract：:The pathological events in human cerebral malaria are mimicked in the experimental cerebral malaria (ECM) in Plasmodium berghei ANKA (PBA)-infected C57BL/6 mice. Although previously implied in ECM, the kinetics of cytokines and chemokines expression-an essential functional feature for defining causality in ECM develop...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.04.025
更新日期：2017-08-01 00:00:00
abstract：:"Anomalous", as yet unreported forms of brood capsules (BC) in cystic echinococcosis larvae from humans and sheep are described, thought to be the likely effect of degenerative involution of the parasite. Morphological examination showed an inner laminated layer (LL) in the brood capsules in intimate contact with the ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2007.12.006
更新日期：2008-03-01 00:00:00
abstract：:The paper summarizes the evolution of a biomedical field research station in Tanzania, established by a European institute, into a national health research and resource centre. The Swiss Tropical Institute Field Laboratory was founded in Ifakara in the Kilombero District in southeastern Tanzania in 1957. It has evolve...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(94)90006-x
更新日期：1994-08-01 00:00:00
abstract：:A schistosomiasis control project was undertaken from 1994 to 1998 in Guruve District, Zimbabwe, based on the active involvement of local communities in the growing and application of the molluscicidal plant Phytolacca dodecandra as a supplement to other control measures such as chemotherapy and health education. The ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(02)00256-5
更新日期：2003-03-01 00:00:00
abstract：:The present work examines the thermal preference of adult Rhodnius prolixus along a temperature gradient. The mean preferred temperature differed slightly between sexes: 25.0 degrees C for males versus 25.4 degrees C for females. This preference was not constant, but varied daily by about 0.2 degrees C for both sexes,...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2003.11.006
更新日期：2004-03-01 00:00:00
