Abstract:
:The biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum requires the construction of four units: the amino sugar from glucose; the anthranilate ring from DL-tryptophan probably via kynurenine; the aromatic methyl group from methionine; the propylidene proline from L-tyrosine with the loss of two aromatic carbons and addition of a C-1 from methionine. Retention of tritium from DL-[5-3H]tryptophan in sibiromycin suggest an NIH shift during hydroxylation of an intermediate.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Hurley LH,Lasswell WL,Malhotra RK,Das NVdoi
10.1021/bi00586a029subject
Has Abstractpub_date
1979-09-18 00:00:00pages
4225-9issue
19eissn
0006-2960issn
1520-4995journal_volume
18pub_type
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