Modeling the T-cell dynamics and pathogenesis of HTLV-I infection.

abstract：:In developmental biology as well as in other biological systems, emerging structure and organization can be captured using time-series data of protein locations. In analyzing this time-dependent data, it is a common challenge not only to determine whether topological features emerge, but also to identify the timing of...

journal_title：Bulletin of mathematical biology

authors： Ciocanel MV,Juenemann R,Dawes AT,McKinley SA

更新日期：2021-01-16 00:00:00

abstract：:Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the formation of blood capillaries (angiogenesis), very few have been proposed for...

journal_title：Bulletin of mathematical biology

authors： Bianchi A,Painter KJ,Sherratt JA

更新日期：2016-09-01 00:00:00

abstract：:National Bureau of Statistics of China reports that the incidence of schistosomiasis has been increasing in recent years. To study dynamic behaviors of schistosomiasis transmission, based on practical experience of staff in Anhui Institute of Schistosomiasis, a mathematical schistosomiasis model with reinfection of re...

journal_title：Bulletin of mathematical biology

authors： Qi L,Xue M,Cui JA,Wang Q,Wang T

更新日期：2018-09-01 00:00:00

abstract：:The mechanical behavior of the actin cytoskeleton has previously been investigated using both experimental and computational techniques. However, these investigations have not elucidated the role the cytoskeleton plays in the compression resistance of cells. The present study combines experimental compression techniqu...

journal_title：Bulletin of mathematical biology

authors： Weafer PP,Ronan W,Jarvis SP,McGarry JP

更新日期：2013-08-01 00:00:00

abstract：:We use a mathematical model to determine the factors affecting the delayed or rare coreceptor switch in HIV-1 subtype C infected individuals. The model takes into account the two main target cells for the CXCR4-tropic and CCR5-tropic virus and includes the the lytic and non-lytic immune responses. Computer-based simul...

journal_title：Bulletin of mathematical biology

authors： Mugwagwa T,Witten G

更新日期：2007-01-01 00:00:00

abstract：:The mutation process is introduced into the colored coalescent theory. The mutation process can be viewed as an independent Poisson process running on the colored genealogical random tree generated by the colored coalescent process, with the edge lengths of the random tree serving as the time scale for the mutation pr...

journal_title：Bulletin of mathematical biology

authors： Tian JP,Lin XS

更新日期：2009-11-01 00:00:00

abstract：:Two algorithms for the efficient identification of segment neighborhoods are presented. A segment neighborhood is a set of contiguous residues that share common features. Two procedures are developed to efficiently find estimates for the parameters of the model that describe these features and for the residues that de...

journal_title：Bulletin of mathematical biology

authors： Auger IE,Lawrence CE

更新日期：1989-01-01 00:00:00

abstract：:More and more evidence shows that mating preference is a mechanism that may lead to a reproductive isolation event. In this paper, a haploid population living on two patches linked by migration is considered. Individuals are ecologically and demographically neutral on the space and differ only on a trait, a or A, affe...

journal_title：Bulletin of mathematical biology

authors： Leman H

更新日期：2018-09-01 00:00:00

abstract：:Autoinhibition of neurotransmitter release occurs via binding of transmitter to appropriate receptors. Experiments have provided evidence suggesting that the control of neurotransmitter release in fast systems is mediated by these inhibitory autoreceptors. Earlier, the authors formulated and analysed a mathematical mo...

journal_title：Bulletin of mathematical biology

authors： Yusim K,Parnas H,Segel LA

更新日期：2000-07-01 00:00:00

abstract：:Posttranslational modification of proteins is key in transmission of signals in cells. Many signaling pathways contain several layers of modification cycles that mediate and change the signal through the pathway. Here, we study a simple signaling cascade consisting of n layers of modification cycles such that the modi...

journal_title：Bulletin of mathematical biology

authors： Feliu E,Knudsen M,Andersen LN,Wiuf C

更新日期：2012-01-01 00:00:00

abstract：:The mammalian kidney consumes a large amount of energy to support the reabsorptive work it needs to excrete metabolic wastes and to maintain homeostasis. Part of that energy is supplied via the metabolism of glucose. To gain insights into the transport and metabolic processes in the kidney, we have developed a detaile...

journal_title：Bulletin of mathematical biology

authors： Chen Y,Fry BC,Layton AT

更新日期：2016-06-01 00:00:00

abstract：:Body size of organisms spans 24 orders of magnitude, and metabolic rate and life span present comparable differences across species. This article shows that this variation can be explained in terms of evolutionary entropy, a statistical parameter which characterizes the robustness of a population, and describes the un...

journal_title：Bulletin of mathematical biology

authors： Demetrius L,Legendre S,Harremöes P

更新日期：2009-05-01 00:00:00

abstract：:Direct reciprocity is a chief mechanism of mutual cooperation in social dilemma. Agents cooperate if future interactions with the same opponents are highly likely. Direct reciprocity has been explored mostly by evolutionary game theory based on natural selection. Our daily experience tells, however, that real social a...

journal_title：Bulletin of mathematical biology

authors： Masuda N,Ohtsuki H

更新日期：2009-11-01 00:00:00

abstract：:The scaling and shift of the gene expression boundary in a developing embryo are two key problems with regard to morphogen gradient formation in developmental biology. In this study, a bigradient model was applied to a nonlinear reaction diffusion system (NRDS) to investigate the location of morphogen gene expression ...

journal_title：Bulletin of mathematical biology

authors： Li WS,Shao YZ

更新日期：2014-06-01 00:00:00

abstract：:Burst-like synthesis of protein is a significant source of cell-to-cell variability in protein levels. Negative feedback is a common example of a regulatory mechanism by which such stochasticity can be controlled. Here we consider a specific kind of negative feedback, which makes bursts smaller in the excess of protei...

journal_title：Bulletin of mathematical biology

authors： Bokes P,Lin YT,Singh A

更新日期：2018-07-01 00:00:00

abstract：:Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. Following thermal stress, expression levels of small heat shock protein-16.2 show a spatial patterning across the 20 intestinal cells that reside along the length of the worm. Here, we present a hypo...

journal_title：Bulletin of mathematical biology

authors： Wentz JM,Mendenhall AR,Bortz DM

更新日期：2018-10-01 00:00:00

abstract：:Premised on relatively simple assumptions, mathematical models like those of Monod, Pirt or Droop inadequately explain the complex transient behavior of microbial populations. In particular, these models fail to explain many aspects of the dynamics of a Tetrahymena pyriformis-Escherichia coli community. In this study ...

journal_title：Bulletin of mathematical biology

authors： Jaworska JS,Hallam TG,Schultz TW

更新日期：1996-03-01 00:00:00

abstract：:The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic cell profiles and their inflammatory growth-factor media...

journal_title：Bulletin of mathematical biology

authors： Olsen L,Sherratt JA,Maini PK

更新日期：1996-07-01 00:00:00

abstract：:Using optimal control theory as the basic theoretical tool, we investigate the efficacy of different antibiotic treatment protocols in the most exacting of circumstances, described as follows. Viewing a continuous culture device as a proxy for a much more complex host organism, we first inoculate the device with a sin...

journal_title：Bulletin of mathematical biology

authors： Peña-Miller R,Lähnemann D,Schulenburg H,Ackermann M,Beardmore R

更新日期：2012-04-01 00:00:00

abstract：:Cholera is an acute gastro-intestinal infection that affects millions of people throughout the world each year, primarily but not exclusively in developing countries. Because of its public health ramifications, considerable mathematical attention has been paid to the disease. Here we consider one neglected aspect of c...

journal_title：Bulletin of mathematical biology

authors： Kobe J,Pritchard N,Short Z,Erovenko IV,Rychtář J,Rowell JT

更新日期：2018-10-01 00:00:00

abstract：:Evolutionary game dynamics of two strategies in finite population is studied by continuous probabilistic approach. Besides frequency dependent selection, mutation was also included in this study. The equilibrium probability density functions of abundance, expected time to extinction or fixation were derived and their ...

journal_title：Bulletin of mathematical biology

authors： Gao M

更新日期：2009-07-01 00:00:00

abstract：:In the field of biological regulation, models dictated by experimental work are usually complex networks comprising intertwined feedback loops. In this paper the biological roles of individual positive loops (multistationarity, differentiation) and negative loops (homeostasis, with or without oscillations, buffering o...

journal_title：Bulletin of mathematical biology

authors： Thomas R,Thieffry D,Kaufman M

更新日期：1995-03-01 00:00:00

abstract：:Cell polarization is an important part of the response of eukaryotic cells to stimuli, and forms a primary step in cell motility, differentiation, and many cellular functions. Among the important biochemical players implicated in the onset of intracellular asymmetries that constitute the early phases of polarization a...

journal_title：Bulletin of mathematical biology

authors： Walther GR,Marée AF,Edelstein-Keshet L,Grieneisen VA

更新日期：2012-11-01 00:00:00

abstract：:Radiation target theory has been extended to complex biochemical systems. Mathematical analyses are presented for multiple forms of biological active proteins, for the presence of large inhibitors or activators, for compounds which regulate rate or affinity and for multiple-step reactions. Several predictions of these...

journal_title：Bulletin of mathematical biology

authors： Kempner ES

更新日期：1995-11-01 00:00:00

abstract：:A method for obtaining delay histograms for the time course of neurotransmitter release is presented. The delay histogram is derived from the measured psc (or the sum of several psc's) and the mpsc (obtained experimentally or otherwise) by means of a simple, quick, mathematical procedure. The procedure may be automate...

journal_title：Bulletin of mathematical biology

authors： Aumann Y,Parnas H

更新日期：1991-01-01 00:00:00

abstract：:Farmers frequently decide where to locate the colonies of their domesticated eusocial bees, especially given the following mutually exclusive scenarios: (i) there are limited nectar and pollen sources within the vicinity of the apiary that cause competition among foragers; and (ii) there are fewer pollinators compared...

journal_title：Bulletin of mathematical biology

authors： Gavina MK,Rabajante JF,Cervancia CR

更新日期：2014-05-01 00:00:00

abstract：:In this work, we show that a one-dimensional model of the blood flow across the lungs can reproduce the evolution of a bolus versus the time. Solving the differential equation governing the bolus concentration in the framework of this model, we determine the solution which fulfills Gaussian initial boundary conditions...

journal_title：Bulletin of mathematical biology

authors： Le Sech C,Capderou A

更新日期：1996-11-01 00:00:00

abstract：:Small populations at risk of extinction due to threshold or competitive exclusion have a vested interest in rapid growth. Taking chance of survival into account for diploid populations, Fisher's theorem predicts a sex ratio favoring females under certain circumstances. Theoretical consideration of competitive exclusio...

journal_title：Bulletin of mathematical biology

authors： Johnson SD

更新日期：2010-01-01 00:00:00

abstract：:Bovine Babesiosis (BB) is a tick borne parasitic disease with worldwide over 1.3 billion bovines at potential risk of being infected. The disease, also called tick fever, causes significant mortality from infection by the protozoa upon exposure to infected ticks. An important factor in the spread of the disease is the...

journal_title：Bulletin of mathematical biology

authors： Friedman A,Yakubu AA

更新日期：2014-01-01 00:00:00

abstract：:For epidemic models, it is shown that fatal infectious diseases cannot drive the host population into extinction if the incidence function is upper density-dependent. This finding holds even if a latency period is included and the time from infection to disease-induced death has an arbitrary length distribution. Howev...

journal_title：Bulletin of mathematical biology

authors： Farrell AP,Collins JP,Greer AL,Thieme HR

更新日期：2018-07-01 00:00:00