Determination of pulmonary mean transit time and cardiac output using a one-dimensional model.

Abstract:

:In this work, we show that a one-dimensional model of the blood flow across the lungs can reproduce the evolution of a bolus versus the time. Solving the differential equation governing the bolus concentration in the framework of this model, we determine the solution which fulfills Gaussian initial boundary conditions. An effective parameter related to the ratio of a diffusion coefficient to the square of the mean speed of the flow is defined. The determination of its numerical values following a semi-empirical approach enables us to know accurately the mean transit time and the cardiac output. The results have been compared to other methods, and were found in good agreement. Such an approach could be of interest in all studies where the knowledge of flow--including micro-circulation--is needed.

journal_name

Bull Math Biol

authors

Le Sech C,Capderou A

doi

10.1007/BF02458387

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

1155-70

issue

6

eissn

0092-8240

issn

1522-9602

journal_volume

58

pub_type

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