Abstract:
:In the field of biological regulation, models dictated by experimental work are usually complex networks comprising intertwined feedback loops. In this paper the biological roles of individual positive loops (multistationarity, differentiation) and negative loops (homeostasis, with or without oscillations, buffering of gene dosage effect) are discussed. The relationship between feedback loops and steady states is then clarified, and the problem: "How can one conveniently disentangle complex networks?" is then considered. Initiated long ago, logical descriptions have been generalized from various viewpoints; these developments are briefly discussed. The recent concept of the loop-characteristic state, defined as the logical state located at the level of the thresholds involved in the loop, together with its application, are then presented. Biological applications are also discussed.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Thomas R,Thieffry D,Kaufman Mdoi
10.1007/BF02460618subject
Has Abstractpub_date
1995-03-01 00:00:00pages
247-76issue
2eissn
0092-8240issn
1522-9602pii
0092-8240(94)00036-Cjournal_volume
57pub_type
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