Abstract：
:Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. Following thermal stress, expression levels of small heat shock protein-16.2 show a spatial patterning across the 20 intestinal cells that reside along the length of the worm. Here, we present a hypothesized mechanism that could lead to this patterned response and develop a mathematical model of this system to test our hypothesis. We propose that the patterned expression of heat shock protein is caused by a diffusion-driven instability within the pseudocoelom, or fluid-filled cavity, that borders the intestinal cells in C. elegans. This instability is due to the interactions between two classes of insulin-like peptides that serve antagonistic roles. We examine output from the developed model and compare it to experimental data on heat shock protein expression. Given biologically bounded parameters, the model presented is capable of producing patterns similar to what is observed experimentally and provides a first step in mathematically modeling aging-related mechanisms in C. elegans.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Wentz JM,Mendenhall AR,Bortz DMdoi
10.1007/s11538-018-0482-7subject
Has Abstractpub_date
2018-10-01 00:00:00pages
2669-2697issue
10eissn
0092-8240issn
1522-9602pii
10.1007/s11538-018-0482-7journal_volume
80pub_type
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