Will drugs help patients with Alzheimer's disease?

abstract：OBJECTIVE:to examine the relationships between impairments in hearing and vision and mortality from all-causes and cardiovascular disease (CVD) among older people. DESIGN:population-based cohort study. PARTICIPANTS:the study population included 4,926 Icelandic individuals, aged ≥67 years, 43.4% male, who completed vi...

journal_title：Age and ageing

authors： Fisher D,Li CM,Chiu MS,Themann CL,Petersen H,Jónasson F,Jónsson PV,Sverrisdottir JE,Garcia M,Harris TB,Launer LJ,Eiriksdottir G,Gudnason V,Hoffman HJ,Cotch MF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:dysphagia is common in acute stroke. Accurate detection of the presence or absence of aspiration by bedside swallowing assessment is difficult without objective methods, tending to over-diagnose aspiration. As a result, some patients suffer restricted oral intake unnecessarily. OBJECTIVE:we examined the pre...

journal_title：Age and ageing

authors： Smith HA,Lee SH,O'Neill PA,Connolly MJ

更新日期：2000-11-01 00:00:00

abstract：:Acute appendicitis in elderly patients has not been studied extensively in the United Kingdom. Studies were performed prior to the regular use of broad spectrum antibiotics and tended to include younger patients. We studied retrospectively all elderly patients (n = 30, mean age = 72 years) who presented in the years 1...

journal_title：Age and ageing

authors： McCallion J,Canning GP,Knight PV,McCallion JS

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for both cardiovascular and cerebrovascular disease, with an increasing incidence with advancing patient age. Exercise interventions have the potential to reduce blood pressure in older adults, however, rates of exercise uptake and adherence are low, with 'lack of time' a common...

journal_title：Age and ageing

authors： Herrod PJJ,Lund JN,Phillips BE

更新日期：2020-10-17 00:00:00

abstract：:The relationship of bone mineral density (BMD) to age and weight was investigated in a cross-sectional study of 942 community-dwelling men and women aged 65-74 years. BMD continues to decline after the age of 65 at a similar rate in men and women. BMD was positively associated with weight in both men and women with si...

journal_title：Age and ageing

authors： May H,Murphy S,Khaw KT

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:hip fractures result in a significant burden to the patient, their caregivers and the health care system. Patients with Alzheimer's disease (AD) have a higher incidence of hip fracture compared with other older people without AD, although it is not clear if AD is an independent risk factor for hip fracture. ...

journal_title：Age and ageing

authors： Baker NL,Cook MN,Arrighi HM,Bullock R

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The Timed Up and Go Test (TUGT) has been recommended as a simple screening tool to identify those at risk of falling. However, subsequent detailed assessment is required to identify underlying falls risk factors to provide direction for optimal targeted intervention strategies. METHODS:110 consecutive falls...

journal_title：Age and ageing

authors： Whitney JC,Lord SR,Close JC

更新日期：2005-11-01 00:00:00

abstract：:We report the case of an 85-year-old male with platypnoea-orthodeoxia associated with patent foramen ovale (PFO) and ectatic ascending aorta, in the absence of any significant pulmonary pathology. ...

journal_title：Age and ageing

authors： Nazir T,Polydorou D,Irwin RB,Cooper A,Woolfson P,Thomson A

更新日期：2012-01-01 00:00:00

abstract：:An outline is given of simple urodynamic investigations applicable to elderly subjects. The type of patient presenting primarily to geriatric departments with urinary incontinence, whose management is aided by such studies, is described under various clinical groupings. The requirement for urodynamic studies and the b...

journal_title：Age and ageing

authors： Eastwood HD

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:cranberry juice is often given to older people in hospital to prevent urinary tract infection (UTI), although there is little evidence to support its use. OBJECTIVE:to assess whether cranberry juice ingestion is effective in reducing UTIs in older people in hospital. DESIGN:randomised, placebo-controlled, ...

journal_title：Age and ageing

authors： McMurdo ME,Bissett LY,Price RJ,Phillips G,Crombie IK

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:prevalence estimates for chronic diseases and associated risk factors are needed for priority setting and disease prevention strategies. The aim of this cross-sectional study was to estimate the self-reported and clinical prevalence of common chronic disorders in elderly men. STUDY DESIGN AND SETTING:a quest...

journal_title：Age and ageing

authors： Frost M,Wraae K,Gudex C,Nielsen T,Brixen K,Hagen C,Andersen M

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:observational studies do not always find positive associations between physical activity and muscle strength despite intervention studies consistently showing that exercise improves strength in older adults. In previous analyses of the MRC National Survey of Health and Development (NSHD), the 1946 British ...

journal_title：Age and ageing

authors： Dodds R,Kuh D,Aihie Sayer A,Cooper R

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Socio-economic differences in mobility disability prevalence in old age have been reported from the US and Europe. Brazil is characterised by gross socio-economic inequalities, but there have been no previous national data on disability prevalence. AIM:This study aimed to estimate disability rates and exp...

journal_title：Age and ageing

authors： Melzer D,Parahyba MI

更新日期：2004-05-01 00:00:00

abstract：Background:pain is prevalent in frail older adults; however, the association of pain and frailty has not been evaluated yet by a systematic assessment of prospective longitudinal studies. Objective:we aimed to assess the association of persistent pain as a risk factor for frailty incidence, using data from longitudina...

journal_title：Age and ageing

authors： Saraiva MD,Suzuki GS,Lin SM,de Andrade DC,Jacob-Filho W,Suemoto CK

更新日期：2018-11-01 00:00:00

abstract：:In Hong Kong, about 15% of older people (aged 80 and above) live in care homes, one of the highest proportions in the world. During the spread of severe acute respiratory syndrome in 2003, the crude fatality rate for older people in care homes that were infected was 72%. After taking the advice of a team of internatio...

journal_title：Age and ageing

authors： Chow L

更新日期：2021-01-08 00:00:00

abstract：Introduction:frailty is an increased vulnerability to adverse health outcomes, across multiple physiological systems, with both environmental and genetic drivers. The two most commonly used measures are Rockwood's frailty index (FI) and Fried's frailty phenotype (FP). Material and methods:the present study included 36...

journal_title：Age and ageing

authors： Livshits G,Ni Lochlainn M,Malkin I,Bowyer R,Verdi S,Steves CJ,Williams FMK

更新日期：2018-01-01 00:00:00

abstract：:We present two cases of acute hepatotoxicity associated with elevated paracetamol (acetaminophen) levels in older patients. Both patients were receiving a standard European dose of oral paracetamol (2 × 500 mg QDS) with no risk factors for slowed metabolism (weight <50 kg, interacting medications, hepatic enzyme induc...

journal_title：Age and ageing

authors： Ging P,Mikulich O,O'Reilly KM

更新日期：2016-07-01 00:00:00

abstract：Background:measuring the complex needs of care home residents is crucial for resource allocation. Hospital patient administration systems (PAS) may not accurately identify admissions from care homes. Objective:to develop and validate an accurate, practical method of identifying care home resident hospital admission us...

journal_title：Age and ageing

authors： Housley G,Lewis S,Usman A,Gordon AL,Shaw DE

更新日期：2018-05-01 00:00:00

abstract：:Fasting serum cholesterol and triglyceride levels, and lipoprotein electrophoretic patterns have been investigated in 42 men aged 67-92 years (mean 79 years). Although all the cholesterol and the majority of the triglyceride levels were within the normal range for younger people, both were significantly greater (P < 0...

journal_title：Age and ageing

authors： Horsey J,Livesley B,Dickerson JW

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:cataract is a leading cause of reversible vision impairment and may increase falls in older adults. OBJECTIVE:to assess the risk of an injury due to a fall among adults aged 60+, 2 years before first-eye cataract surgery, between first-eye surgery and second-eye surgery and 2 years after second-eye surgery....

journal_title：Age and ageing

authors： Meuleners LB,Fraser ML,Ng J,Morlet N

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:vascular disease has been postulated to contribute to muscle dysfunction in old age. Previous studies examining the effects of cardiovascular drugs on muscle function have shown conflicting results. We therefore examined the association of angiotensin converting enzyme (ACE) inhibitor, thiazide and statin us...

journal_title：Age and ageing

authors： Witham MD,Syddall HE,Dennison E,Cooper C,McMurdo ME,Sayer AA

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The electronic Frailty Index (eFI) has been developed in primary care settings. The Hospital Frailty Risk Score (HFRS) was derived using secondary care data. OBJECTIVE:Compare the two different tools for identifying frailty in older people admitted to hospital. DESIGN AND SETTING:Retrospective cohort study...

journal_title：Age and ageing

authors： Hollinghurst J,Housley G,Watkins A,Clegg A,Gilbert T,Conroy SP

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Delirium is a common neuropsychiatric disorder. The natural course is of an acute, fluctuating and often transient condition; however, accumulating evidence suggests that delirium can be associated with incomplete recovery. Despite a growing body of research, a lack of clarity exists regarding definition and...

journal_title：Age and ageing

authors： Adamis D,Devaney A,Shanahan E,McCarthy G,Meagher D

更新日期：2015-03-01 00:00:00

abstract：:A study is reported of the religious beliefs, attitudes, and practice of old people in the West of Scotland, based on a questionnaire given to 501 people aged 65 years and over randomly selected from those living at home. Almost all had had a full range of religious instruction, and regarded their parents as religious...

journal_title：Age and ageing

authors： Reid WS,Gilmore AJ,Andrews GR,Caird FI

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:dementia is associated with an excess risk of death but mortality after chronic subdural hematoma (CSDH) evacuation in older people with dementia is unknown. We assessed the association between dementia and 1-year case-fatality in older persons undergoing CSDH evacuation. METHODS:we conducted a nationwide F...

journal_title：Age and ageing

authors： Tommiska P,Korja M,Siironen J,Kaprio J,Raj R

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:information about the predictors of mortality among the oldest-old is limited. Also possible gender differences are poorly known. OBJECTIVE:to examine the predictors of mortality among individuals aged 90 and older, focusing on differences between men and women. We also analysed gender differences in surviv...

journal_title：Age and ageing

authors： Tiainen K,Luukkaala T,Hervonen A,Jylhä M

更新日期：2013-07-01 00:00:00

abstract：:We have measured the rate of induction of the microsomal monooxygenase enzyme aryl hydrocarbon hydroxylase (AHH) in isolated peripheral blood monocytes from young and elderly donors. There was no effect of age on rate of induction. The mechanisms underlying impaired induction of drug metabolism in elderly people remai...

journal_title：Age and ageing

authors： George G,Wynne H,Woodhouse K

更新日期：1991-11-01 00:00:00

abstract：:This invited article is drawn from the content of the Marjory Warren Lecture given by John Gladman at the British Geriatrics Society Spring Meeting in 2018, entitled 'The Meaning of Life Expectancy'. ...

journal_title：Age and ageing

authors： Gladman JRF

更新日期：2019-01-01 00:00:00

abstract：Background:harmful alcohol consumption is reported to be increasing in older people. To intervene and reduce associated risks, evidence currently available needs to be identified. Methods:two systematic reviews in older populations (55+ years): (1) Interventions to prevent or reduce excessive alcohol consumption; (2) ...

journal_title：Age and ageing

authors： Kelly S,Olanrewaju O,Cowan A,Brayne C,Lafortune L

更新日期：2018-03-01 00:00:00

abstract：:Orthostatic hypotension is a common problem in older adults and can be associated with falls, dizziness and syncope and their associated consequences. Therefore, it is important to recognise the condition and institute appropriate management. We report an elderly woman who presented with orthostatic hypotension and wa...

journal_title：Age and ageing

authors： Bragg F,Kumar NP

更新日期：2005-05-01 00:00:00