Unexpected paracetamol (acetaminophen) hepatotoxicity at standard dosage in two older patients: time to rethink 1 g four times daily?

abstract：OBJECTIVES:The purpose of this paper is to investigate the utilisation of general practice Medicare Benefit Schedule (MBS) services aligned to Comprehensive Geriatric Assessment (CGA) within 6 months of an aged care eligibility assessment and its effects on mortality and transition to permanent residential aged care (P...

journal_title：Age and ageing

authors： Visvanathan R,Amare AT,Wesselingh S,Inacio MC

更新日期：2020-12-23 00:00:00

abstract：INTRODUCTION:care home residents have high healthcare needs not fully met by prevailing healthcare models. This study explored how healthcare configuration influences resource use. METHODS:a realist evaluation using qualitative and quantitative data from case studies of three UK health and social care economies select...

journal_title：Age and ageing

authors： Gordon AL,Goodman C,Davies SL,Dening T,Gage H,Meyer J,Schneider J,Bell B,Jordan J,Martin FC,Iliffe S,Bowman C,Gladman JRF,Victor C,Mayrhofer A,Handley M,Zubair M

更新日期：2018-07-01 00:00:00

abstract：:The objective of this study was to determine whether the Short-form 36 Health Status Questionnaire (SF-36) is suitable for use in an elderly population. The SF-36 was administered by interview to a random sample of 827 adults from West Glamorgan. Among the 216 adults aged 65 and over the data were 98.8% complete. Evid...

journal_title：Age and ageing

authors： Lyons RA,Perry HM,Littlepage BN

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:older people aged 80 and over are increasingly providing end-of-life care to spouses at home and often do so for long periods of time, while also trying to manage their own illnesses and disabilities. Little of the research on older spousal carers has focussed on the oldest carers; hence, the needs of this p...

journal_title：Age and ageing

authors： Turner M,King C,Milligan C,Thomas C,Brearley SG,Seamark D,Wang X,Blake S,Payne S

更新日期：2016-05-01 00:00:00

abstract：UNLABELLED:Older people are majority users of health and social care services in the UK and internationally. Many older people who access these services have frailty, which is a state of vulnerability to adverse outcomes. The existing health care response to frailty is mainly secondary care-based and reactive to the ac...

journal_title：Age and ageing

authors： Turner G,Clegg A,British Geriatrics Society.,Age UK.,Royal College of General Practioners.

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:arterial stiffening is a marker of vascular ageing and an independent risk factor for cardiovascular disease. A potential mechanism linking cardiovascular disease to chronic kidney disease might be the change in arterial elasticity. We aim to determine the association between renal function and arterial stif...

journal_title：Age and ageing

authors： Sedaghat S,Dawkins Arce FG,Verwoert GC,Hofman A,Ikram MA,Franco OH,Dehghan A,Witteman JC,Mattace-Raso F

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:frequent emergency department (ED) attendance at the end of life disrupts care continuity and contradicts most patients' preference for home-based care. OBJECTIVE:to examine factors associated with frequent (≥3) end of life ED attendances among older people to identify opportunities to improve care. METHOD...

journal_title：Age and ageing

authors： Bone AE,Evans CJ,Henson LA,Gao W,Higginson IJ,BUILDCARE study.

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:frailty is a dynamic condition for which a range of interventions are available. Health state utilities are values that represent the strength of an individual's preference for specific health states, and are used in economic evaluation. This is a topic yet to be examined in detail for frailty. Likewise, lit...

journal_title：Age and ageing

authors： Thompson MQ,Theou O,Ratcliffe J,Tucker GR,Adams RJ,Walters SJ,Visvanathan R

更新日期：2020-09-16 00:00:00

abstract：BACKGROUND:the 16-item Falls Efficacy Scale-International (FES-I) has been shown to have excellent reliability and construct validity. However, for practical and clinical purposes, a shortened version of the FES-I would be useful. OBJECTIVE:to develop and validate a shortened version of FES-I while preserving good psy...

journal_title：Age and ageing

authors： Kempen GI,Yardley L,van Haastregt JC,Zijlstra GA,Beyer N,Hauer K,Todd C

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:the absolute number of notifications for tuberculosis in older people appears to have increased in Scotland. To determine if these trends are present elsewhere in the UK, we have reviewed notifications in Leeds with particular reference to non-pulmonary disease, Asian subcontinent groups and older people. M...

journal_title：Age and ageing

authors： Phelan F,Teale C

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:the empirical Dignity Model has profoundly influenced the provision of palliative care for older terminally ill patients in the West, as it provides practical guidance and intervention strategies for promoting dignity and reducing distress at the end-of-life. OBJECTIVE:to examine the concept of 'living and ...

journal_title：Age and ageing

authors： Ho AH,Chan CL,Leung PP,Chochinov HM,Neimeyer RA,Pang SM,Tse DM

更新日期：2013-07-01 00:00:00

abstract：:Digoxin elimination phase kinetics have been studied in 24 hospital in-patients (mean age 79 years), six of whom showed no evidence of digoxin toxicity. The others, with suspected toxicity, have been grouped according to the nature of the drug effects observed. Renal function, digoxin elimination half-life, apparent v...

journal_title：Age and ageing

authors： Reid J,Kennedy RD,Caird FI

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:the nursing home Resident Assessment Instrument (RAI) includes a set of core assessment items, known as the Minimum Data Set (MDS), for assessment and care screening and more detailed Resident Assessment Protocols in 18 areas that represent common problem areas or risk factors for nursing home residents. Its...

journal_title：Age and ageing

authors： Hawes C,Morris JN,Phillips CD,Fries BE,Murphy K,Mor V

更新日期：1997-09-01 00:00:00

abstract：:Fasting serum cholesterol and triglyceride levels, and lipoprotein electrophoretic patterns have been investigated in 42 men aged 67-92 years (mean 79 years). Although all the cholesterol and the majority of the triglyceride levels were within the normal range for younger people, both were significantly greater (P < 0...

journal_title：Age and ageing

authors： Horsey J,Livesley B,Dickerson JW

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:to investigate auditory function in subjects with early Alzheimer's disease, mild cognitive impairment and with subjective memory complaints, in search of signs of central auditory processing dysfunction even in early stages of cognitive impairment. DESIGN AND SUBJECTS:a consecutive group of men and women, r...

journal_title：Age and ageing

authors： Idrizbegovic E,Hederstierna C,Dahlquist M,Kämpfe Nordström C,Jelic V,Rosenhall U

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:to compare walking speed in the UK older population with the speed required to utilise pedestrian crossings (≥1.2 m/s), and determine health and socio-demographic associations with walking impairment. DESIGN:cross-sectional study using Health Survey for England 2005 data. SETTING:private households in Engl...

journal_title：Age and ageing

authors： Asher L,Aresu M,Falaschetti E,Mindell J

更新日期：2012-09-01 00:00:00

abstract：:Chronic simple glaucoma is a common disease in old age and lowering intraocular pressure is the treatment strategy. Although this can be achieved surgically, medical treatment with eye drops is more often prescribed. Beta-antagonists are the class of drug most often chosen, although other medical therapies are availab...

journal_title：Age and ageing

authors： Diggory P,Franks WA

更新日期：1997-03-01 00:00:00

abstract：:We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p < 0.01) together with a parallel increase in urinary (r = 0.46, p < 0.05) and nephrogenic cAMP (r = 0.63, p < 0....

journal_title：Age and ageing

authors： Ravaglia G,Forti P,Pratelli L,Maioli F,Scali CR,Bonini AM,Tedioli S,Marasti N,Pizzoferrato A,Gasbarrini G

更新日期：1994-03-01 00:00:00

abstract：:Myasthenia gravis is probably commoner than previously suspected, the annual incidence being nearer 9-10/million than earlier figures of 2-4/million. The current study found an annual incidence in Croyden of 9.1 per million (95% confidence limits 5.7-13.8 per million). Of the 22 patients (59%) seen in Croyden with new...

journal_title：Age and ageing

authors： Schon F,Drayson M,Thompson RA

更新日期：1996-01-01 00:00:00

abstract：:Muscle cramps are painful and common in elderly patients but have largely escaped medical investigation. Quinine sulphate is usually the sole drug prescribed, even though firm evidence for its efficacy is not available. The results of the present double-blind cross-over study show that quinine was significantly superi...

journal_title：Age and ageing

authors： Jones K,Castleden CM

更新日期：1983-05-01 00:00:00

abstract：:The course of Motor Neurone Disease (MND) is described in 22 patients in respect of the extent and duration of the disabilities. The average stay in hospital in the terminal phase in 20 patients followed to the time of their death was 6.6 months for men and 4.7 months for women. The total duration of the disease range...

journal_title：Age and ageing

authors： Rosin AJ

更新日期：1976-02-01 00:00:00

abstract：:Plasma Human Growth Hormone (HGH) was raised in a patient with bronchial carcinoma and hypertrophic pulmonary osteoarthropathy before radiotherapy to the tumour. Though the soft-tissue swelling and pain of hypertrophic osteoarthropathy disappeared two to three weeks after radiotherapy to the carcinoma the HGH plasma l...

journal_title：Age and ageing

authors： Mukherjee SK

更新日期：1975-05-01 00:00:00

abstract：:We report the case of an 85-year-old male with platypnoea-orthodeoxia associated with patent foramen ovale (PFO) and ectatic ascending aorta, in the absence of any significant pulmonary pathology. ...

journal_title：Age and ageing

authors： Nazir T,Polydorou D,Irwin RB,Cooper A,Woolfson P,Thomson A

更新日期：2012-01-01 00:00:00

abstract：:Tests of intestinal permeability are used as a reflection of upper-small-intestinal mucosal damage. Thirty-two elderly in-patients aged 75-96 years, and 64 hospital volunteers aged 22-64 years with no overt gastro-intestinal disease were studied to determine whether permeability changes with increasing age. Intestinal...

journal_title：Age and ageing

authors： Saweirs WM,Andrews DJ,Low-Beer TS

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common. These may not always be reported in the literature. CASE REPORT:A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigat...

journal_title：Age and ageing

authors： Blunt DM,Impallomeni MG

更新日期：2004-03-01 00:00:00

abstract：INTRODUCTION:Routine cognitive screening for in-patients aged ≥75 years is recommended, but there is uncertainty around how this should be operationalised. We therefore determined the feasibility and reliability of the Abbreviated mental test score (AMTS/10) and its relationship to subjective memory complaint, Montreal...

journal_title：Age and ageing

authors： Pendlebury ST,Klaus SP,Mather M,de Brito M,Wharton RM

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:dysphagia is common following stroke and is associated with the development of pneumonia. Many dysphagia treatment options are available, some still experimental and others already rooted in common practice. Previous reviews of these treatments were limited due to a dearth of available studies. Recently, mor...

journal_title：Age and ageing

authors： Foley N,Teasell R,Salter K,Kruger E,Martino R

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:to provide evidence for predictors of recovery in instrumental activities of daily living (IADLs) among disabled older people living in the community. DESIGN:MRC CFAS recruited a sample of 13,004 individuals aged 65 years and above from five communities in the UK. Participants underwent a baseline interview ...

journal_title：Age and ageing

authors： Seidel D,Jagger C,Brayne C,Matthews FE,Cfas M

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:STOPP/START was formulated to identify potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) in older people. The purpose of this study was to determine the prevalence of PIP and PPO in older Irish patients in residential care using STOPP/START. METHODS:data were collected p...

journal_title：Age and ageing

authors： Ryan C,O'Mahony D,Kennedy J,Weedle P,Cottrell E,Heffernan M,O'Mahony B,Byrne S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To compare costs and outcome of occupational therapy-led assessment with social worker-led assessment of older people, in terms of their independence and quality of life. DESIGN:Cost-effectiveness analysis alongside a randomised controlled trial. The analysis took viewpoints of health services and patients....

journal_title：Age and ageing

authors： Flood C,Mugford M,Stewart S,Harvey I,Poland F,Lloyd-Smith W

更新日期：2005-01-01 00:00:00