Abstract:
BACKGROUND:arterial stiffening is a marker of vascular ageing and an independent risk factor for cardiovascular disease. A potential mechanism linking cardiovascular disease to chronic kidney disease might be the change in arterial elasticity. We aim to determine the association between renal function and arterial stiffness in older subjects. DESIGN:cross-sectional study. SETTING:Rotterdam study, a population-based cohort study. SUBJECTS:we included 3,279 subjects from 1997 to 1999 with a mean age of 71.9 years. METHODS:estimation of glomerular filtration rate (eGFR) was used to assess renal function. Aortic pulse wave velocity (PWV) and carotid distensibility coefficient were used as measures of arterial stiffness. RESULTS:each standard deviation increase in eGFR, adjusting for age and sex, was associated with 0.14 m/s lower PWV [95% confidence interval (CI): -0.23, -0.05]. Further adjustments for socio-demographic and cardiovascular risk factors did not change the association (β: -0.16 m/s; 95% CI: -0.26, -0.06). There was a linear association between mean values of PWV and quartiles of glomerular filtration rate (P for trend = 0.006). There was no association between decreased renal function and carotid distensibility. There was no statistical difference in the strength of the association between renal function and PWV in subgroups of participants with and without cardiovascular risk factors. CONCLUSIONS:in this large population-based study of elderly subjects, our findings suggest that renal impairment is associated with aortic stiffness. This association is independent of cardiovascular risk factors.
journal_name
Age Ageingjournal_title
Age and ageingauthors
Sedaghat S,Dawkins Arce FG,Verwoert GC,Hofman A,Ikram MA,Franco OH,Dehghan A,Witteman JC,Mattace-Raso Fdoi
10.1093/ageing/afu111subject
Has Abstractpub_date
2014-11-01 00:00:00pages
827-33issue
6eissn
0002-0729issn
1468-2834pii
afu111journal_volume
43pub_type
杂志文章相关文献
AGE AND AGEING文献大全abstract:BACKGROUND:The long-term effectiveness of group continence promotion delivered via community organisations on female urinary incontinence, falls and healthy life expectancy remains unknown. METHODS:A pragmatic cluster randomised trial was conducted among 909 women aged 65-98 years with urinary incontinence, recruited ...
journal_title:Age and ageing
pub_type: 杂志文章,随机对照试验
doi:10.1093/ageing/afz038
更新日期:2019-07-01 00:00:00
abstract::The use of a teaching machine is the assessment of mental function has been described by Gredye and his colleagues. This report concerns its use in testing 56 elderly patients suffering from functional psychiatric disorders of dementia. After a diagnostic interview patients were tested on the teaching machine as well ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/4.2.110
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:animal studies suggest a neuroprotective role for leptin, but human studies have shown mixed results. We examined whether plasma leptin levels in individuals with mild cognitive impairment (MCI) were related to cognitive function at baseline and whether higher leptin levels were associated with reduced risk ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afu160
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was to determine whether the Short-form 36 Health Status Questionnaire (SF-36) is suitable for use in an elderly population. The SF-36 was administered by interview to a random sample of 827 adults from West Glamorgan. Among the 216 adults aged 65 and over the data were 98.8% complete. Evid...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/23.3.182
更新日期:1994-05-01 00:00:00
abstract::This paper describes how a sample of elderly people were identified from the electoral register using an initial postal screen, and reports a technique that was used to increase the response to the screen. ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/16.2.119
更新日期:1987-03-01 00:00:00
abstract::Bone's mechanical competence and its fragility in particular depend to a certain extent on the structure and microstructure of the cortical bone compartment. Beyond bone mineral density (BMD) and bone mineral content, a variety of other features of cortical bone contribute to whole bone's resistance to fracture. Struc...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/afl081
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. DESIGN:a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/aft191
更新日期:2014-05-01 00:00:00
abstract:Introduction:frailty is an increased vulnerability to adverse health outcomes, across multiple physiological systems, with both environmental and genetic drivers. The two most commonly used measures are Rockwood's frailty index (FI) and Fried's frailty phenotype (FP). Material and methods:the present study included 36...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afx122
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Age is thought to be strongly associated with intensive care outcomes, but this relationship may be confounded by many clinical variables. OBJECTIVES:To compare clinical characteristics of elderly patients (> or = 65 years) admitted to the intensive care unit (ICU) with those in younger patients and to iden...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afi037
更新日期:2005-03-01 00:00:00
abstract::Investigation of 21 elderly women with a wide range of renal function showed that plasma creatinine concentrations above 100 mumol/l were associated with glomerular filtration rates (GFR) below 50 ml/min. Plasma 1,25-dihydroxyvitamin D concentrations and radio-calcium absorption were directly related to GFR and were l...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/13.1.14
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The reason why elderly human hips tend to break in one of two anatomical regions is uncertain. Nutritional factors may affect the site of fracture. OBJECTIVE:To assess possible nutritional differences in patients with proximal femoral fractures. DESIGN:Prospective observational cohort study. SETTING:Unive...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/28.5.458
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:to examine whether the Danish 1905 cohort members had more active hospital treatment than the 1895 cohort members from ages 85 to 99 years and whether it results in higher in-hospital and post-operative mortality. METHODS:in the present register-based follow-up study the complete Danish birth cohorts born in...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/aft031
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:early mobilization after hip fracture (HF) is an important predictor of outcome, but knowledge of the consequences of not achieving the pre-fracture basic mobility status in acute hospital recovery is sparse. OBJECTIVE:we examined whether the regain of pre-fracture basic mobility status evaluated with the c...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afy185
更新日期:2019-03-01 00:00:00
abstract::The elastic and mechanical behaviour of isolated papillar muscle was studied in aged and in young rats. The spontaneous fall in tension (stress relaxation phenomenon) and the duration of the active state of the contractile element during the isometric and isotonic contraction were greater in aged than in young rats. T...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/5.2.71
更新日期:1976-05-01 00:00:00
abstract:CASE REPORT:An elderly woman with poor nutritional intake developed profound hypophosphataemia and hypokalaemia following the institution of nasogastric feeding. DISCUSSION:Refeeding syndrome is well recognized in certain undernourished groups of patients, but may not be so well known to physicians looking after elder...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/31.1.65
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:(i) to describe the general practitioner utilisation of health assessments, management plans, coordination of team care arrangements and medication review item numbers within 6 months of an aged care eligibility assessment for home care packages (HCP) and (ii) investigate the impact of health assessments on t...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afaa091
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND:delirium is under-recognised in comparison to other common and serious acute disorders. A 2006 survey of UK junior doctors (not undertaking specialist training) identified poor knowledge of the diagnostic criteria and treatment of delirium. We hypothesised that increased prominence accorded to delirium in th...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afw066
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Eating by oneself may be a risk factor for mental illness among older adults, but may be influenced by cohabitation status. We examined the association between eating alone and depression in the context of cohabitation status in older adults in Japan. DESIGN:A longitudinal, population-based study. SETTING:...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afv145
更新日期:2015-11-01 00:00:00
abstract:Objective:to describe differences in care and 30-day mortality of patients admitted with hip fracture on weekends (Saturday-Sunday) compared to weekdays (Monday-Friday), and their relationship to the organisation of care. Methods:data came from the National Hip Fracture Database (NHFD) linked to ONS mortality data on ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afy074
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:polypharmacy is an important risk factor for falls, but recent studies suggest only when including medications associated with increasing the risk of falls. DESIGN:a prospective, population-based cohort study. SUBJECTS:6,666 adults aged ≥50 years from The Irish Longitudinal study on Ageing. METHODS:partic...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afu141
更新日期:2015-01-01 00:00:00
abstract::Genetic factors are known to be of importance in determining the rate of biotransformation of foreign compounds in the liver. Adverse reactions to drugs are increased and pharmacokinetic parameters altered with age. In the present study, the effect of age on plasma paroxonase activity is studied. Paroxonase is a hepat...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/6.2.89
更新日期:1977-05-01 00:00:00
abstract:Background:older patients admitted to hospitals are at risk for hospital-acquired morbidity related to immobility. The aim of this study was to implement and evaluate an evidence-based intervention targeting staff to promote early mobilisation in older patients admitted to general medical inpatient units. Methods:the ...
journal_title:Age and ageing
pub_type: 杂志文章,多中心研究
doi:10.1093/ageing/afx128
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:COVID-19 has disproportionately affected older people. OBJECTIVE:The objective of this paper to investigate whether frailty is associated with all-cause mortality in older hospital inpatients, with COVID-19. DESIGN:Cohort study. SETTING:Secondary care acute hospital. PARTICIPANTS:Participants included ar...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afaa184
更新日期:2020-10-23 00:00:00
abstract::From a study of routine electrocardiography on 300 ill elderly patients in an acute geriatric unit, it is evident that the incidence of atrial fibrillation, ventricular extrasystoles, myocardial ischaemia and myocardial infarction is much higher than in the general population of similar age group. In females, the inci...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/6.3.163
更新日期:1977-08-01 00:00:00
abstract::Explicit criteria, such as the STOPP/START criteria, are increasingly used both in clinical practice and in research to identify potentially inappropriate prescribing in older people. In an article on the STOPP/START criteria version 2, O'Mahony et al have pointed out the advantages of developing computerised criteria...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afw114
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:physical and mental health are important risk factors for cardiovascular disease (CVD) incidence and death among postmenopausal women. The objective of this study was to assess whether changes in physical and mental health were associated with CVD incidence and death. METHODS:in the Women's Health Initiativ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afy213
更新日期:2019-05-01 00:00:00
abstract::To determine whether medication use differs by cognitive status among community dwelling elderly, a survey was made of a stratified random sample of 4110 black and white participants, aged 65 or older from the Duke Established Populations for Epidemiologic Studies of the Elderly in five adjacent urban and rural counti...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/25.3.190
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the influence of age on the day-night blood pressure rhythm and on the prevalence of vascular events in those whose systolic blood pressure (SBP) fell by <10% overnight (non-dippers). DESIGN:Cross-sectional observational cohort study. SETTING:Outpatient hypertension clinic. PARTICIPANTS:419 Hy...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/28.1.23
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:age-related hearing loss is a common chronic condition; hence, it is important to understand its influence on the functional status of older adults. We assessed the association between hearing impairment with activity limitations as assessed by the activities of daily living (ADL) scale. METHODS:a total of ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afr155
更新日期:2012-03-01 00:00:00
abstract::Of 212 cases of peritonitis found in a retrospective study of geriatric inpatients, the most common causes were mesenteric infarction, malignancy, intestinal obstruction, perforated peptic ulcer, cholecystitis, diverticulitis and perforation of the urinary bladder. The diagnostic accuracy was 47%. Abdominal pain had b...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/20.2.90
更新日期:1991-03-01 00:00:00