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Copper(II) and nickel(II) ternary complexes of L-dopa and related compounds.

Abstract：

:The stability constants of the mixed ligand complexes of L-dopa, L-tyrosine, L-phenylalanine, and dopamine with copper(II) and nickel(II) ions and with 2,2'-bipyridyl and 1,10-phenanthroline were determined pH-metrically at 25 degrees C and an ionic strength of 0.2 mol/dm3 (KCl). Spectral studies were made to establish the binding mode of the ambidentate L-dopa in the ternary complexes. In contrast with the aromatic (N,N) donor atoms, the (O,O) binding mode of L-dopa is particularly favored in its ternary systems with copper(II) and nickel(II); thus, even at physiological pH there is a very considerable formation of (O,O)-bound mixed ligand complexes containing a free amino acid side-chain. Numerous binary transition metal-L-dopa complexes and the ternary complexes formed with various B ligands have been evaluated from a coordination chemistry aspect, with regard to the possibility of their therapeutic application in the treatment of Parkinson disease.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Kiss T,Gergely A

doi

10.1016/0162-0134(85)80024-6

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

247-59

issue

4

eissn

0162-0134

issn

1873-3344

pii

0162-0134(85)80024-6

journal_volume

25

pub_type

杂志文章

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