Effect of associated antiepileptic treatment on valproate-induced hyperammonemia.

abstract：:The analysis of pentamidine in whole blood, plasma, and urine by liquid chromatography is described. Extraction was made with a mixture of acetonitrile and chloroform followed by back-extraction into phosphate buffer. A reversed-phase chromatographic system with fluorescence detection was used. The precision of the me...

journal_title：Therapeutic drug monitoring

authors： Ericsson O,Rais M

更新日期：1990-07-01 00:00:00

abstract：:In a crossover study balanced for sex, treatments, and treatment order, we have investigated the pharmacokinetics of diltiazem after single oral doses in 10 healthy middle-aged volunteers. The diltiazem doses employed were 60 mg and 120 mg and contained 1.85 MBq [14C] diltiazem. The absorption was rapid and did not di...

journal_title：Therapeutic drug monitoring

authors： Höglund P,Nilsson LG

更新日期：1989-09-01 00:00:00

abstract：:Itraconazole is a new triazole antifungal agent. Active orally, this drug is effective against a wide range of fungal pathogens that includes Aspergillus species, and its use in leukemic and AIDS patients is currently on the increase. Oral itraconazole absorption presents up to threefold interindividual variation in m...

journal_title：Therapeutic drug monitoring

authors： Poirier JM,Lebot M,Descamps P,Levy M,Cheymol G

更新日期：1994-12-01 00:00:00

abstract：:The time course of appearance of cotinine in saliva and in daily collections of beard clippings was monitored by gas chromatography with mass spectrometry in six volunteers who were nonsmokers following a single 30-min buccal administration of nicotine as a chewing gum. Salivary cotinine concentrations reached a plate...

journal_title：Therapeutic drug monitoring

authors： Gwent SH,Wilson JF,Tsanaclis LM,Wicks JF

更新日期：1995-04-01 00:00:00

abstract：:The adsorption of amitriptyline, desipramine, doxepin, imipramine, and nortriptyline onto cholestyramine was demonstrated in vitro with use of 1.2 mol/L HCl at 37 degrees C to simulate gastric fluid. Binding to cholestyramine was approximately 80% for each of the tricyclic antidepressants, and this was about the same ...

journal_title：Therapeutic drug monitoring

authors： Bailey DN,Coffee JJ,Anderson B,Manoguerra AS

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Solithromycin is a fourth-generation macrolide antibiotic with potential efficacy in pediatric community-acquired bacterial pneumonia. Pharmacokinetic (PK) studies of solithromycin in pediatric subjects are limited, therefore application of minimally invasive drug sampling techniques, such as dried blood spo...

journal_title：Therapeutic drug monitoring

authors： Beechinor RJ,Cohen-Wolkowiez M,Jasion T,Hornik CP,Lang JE,Hernandez R,Gonzalez D

更新日期：2019-12-01 00:00:00

abstract：:A rapid and reliable micro procedure for the high pressure liquid chromatographic analysis of cimetidine. N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, in serum or plasma is described. The percentage analytical recovery of cimetidine and internal standard (beta-hydroxypropyl-theophy...

journal_title：Therapeutic drug monitoring

authors： Soldin SJ,Fingold DR,Fenje PC,Mahon WA

更新日期：1979-01-01 00:00:00

abstract：:Determination of serum concentrations of certain drugs is becoming increasingly important for optimal patient care. These drugs include many antibiotics, several antiarrhythmics, cardiac glycosides, lithium, phenytoin, some other anticonvulsants, salicylates, and theophylline. Serum level determinations can also be us...

journal_title：Therapeutic drug monitoring

authors： Koch-Weser J

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV)-infected individuals show large interindividual variation in response to antiretroviral therapy. Efavirenz (EFV) and nevirapine (NVP) are nonnucleoside reverse transcriptase inhibitors, which are prescribed in combination with other antiretroviral therapy in so-called highl...

journal_title：Therapeutic drug monitoring

authors： Heil SG,van der Ende ME,Schenk PW,van der Heiden I,Lindemans J,Burger D,van Schaik RH

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics of long-acting intramuscular paliperidone in a naturalistic setting is not well documented. The objective of this study was to investigate the relationship between dose and serum concentrations of paliperidone using data from a routine therapeutic drug monitoring service. METHODS:Serum ...

journal_title：Therapeutic drug monitoring

authors： Helland A,Spigset O

更新日期：2017-12-01 00:00:00

abstract：:A case of desmethylimipramine (DMI) overdose is described. The analysis of DMI and its main metabolite, 2-hydroxydesmethylimipramine (2-OH-DMI), in plasma was performed by high performance liquid chromatography with fluorescence detection. Characterization of the elimination kinetics of DMI by using the SAAM 25 comput...

journal_title：Therapeutic drug monitoring

authors： Spina E,Henthorn TK,Eleborg L,Nordin C,Säwe J

更新日期：1985-01-01 00:00:00

abstract：:The aim of this study was to assess dose-related steady-state serum concentrations of olanzapine (OLZ) and its metabolites N-desmethyl OLZ (DMO) and 2-hydroxymethyl OLZ (2-OH-OLZ) (assessed by high-performance liquid chromatography) in 122 child and adolescent psychiatric patients (age 16.9 +/- 2.2, range, 10-21 years...

journal_title：Therapeutic drug monitoring

authors： Theisen FM,Haberhausen M,Schulz E,Fleischhaker C,Clement HW,Heinzel-Gutenbrunner M,Remschmidt H

更新日期：2006-12-01 00:00:00

abstract：:During once-daily dosing regimens of aminoglycosides, administration of large single doses results in high peak levels and low 24-h trough levels. However, commercial assays for monitoring aminoglycoside levels are designed to cover the smaller range of serum concentrations usually observed during multiple daily dosin...

journal_title：Therapeutic drug monitoring

authors： Blaser J,König C,Fatio R,Follath F,Cometta A,Glauser M

更新日期：1995-04-01 00:00:00

abstract：:The binding characteristics of the antiepileptic agent and teratogen valproic acid for human serum and human placenta were investigated utilizing equilibrium dialysis of the drugs in serum and in homogenates of whole placenta so that the transplacental transfer of the drug could be better defined. A low-capacity, high...

journal_title：Therapeutic drug monitoring

authors： Bailey DN,Briggs JR

更新日期：2005-06-01 00:00:00

abstract：:The greater and more consistent absorption of cyclosporine from the microemulsion formulation (Neoral; Novartis Pharmaceuticals Ltd., Frimley, UK) when compared with that from the original form (Sandimmune; Novartis Pharmaceuticals Ltd., Frimley, UK) results in greater systemic exposure. Lung transplant recipients cou...

journal_title：Therapeutic drug monitoring

authors： Trull A,Steel L,Sharples L,Stewart S,Parameshwar J,McNeil K,Wallwork J

更新日期：1999-02-01 00:00:00

abstract：:The clinical correlates of methylphenidate blood levels in hyper-active children and normal adults were examined in five studies. Although occasional correlations between blood levels and neuroendocrine response were noted within subjects along the pharmacokinetic time profile of the drug, no significant associations ...

journal_title：Therapeutic drug monitoring

authors： Gualtieri CT,Hicks RE,Patrick K,Schroeder SR,Breese GR

更新日期：1984-01-01 00:00:00

abstract：:A 64-year-old man on chronic hemodialysis for end-stage renal disease developed peritoneal carcinomatosis, and palliative chemotherapy with fluorouracil was started. The drug was administered (325 mg/m as IV bolus, at 2 PM) on 2 separate occasions, ie, 1 hour after dialysis and 2 days later, 49 hours after dialysis. T...

journal_title：Therapeutic drug monitoring

authors： Gusella M,Rebeschini M,Cartei G,Ferrazzi E,Ferrari M,Padrini R

更新日期：2005-12-01 00:00:00

abstract：:The authors describe a rapid, useful, specific, and very sensitive high-performance liquid chromatographic assay for the determination of fluvastatin (FV) level using atorvastatin as the internal standard (IS). After a simple deproteinization of 1.0 mL of plasma with acetonitrile, the drug and IS were extracted with t...

journal_title：Therapeutic drug monitoring

authors： Al-Rawithi S,Hussein RF,Alzahrani A

更新日期：2003-02-01 00:00:00

abstract：:Sotrastaurin (AEB071) is an investigational immunosuppressant that blocks T-lymphocyte activation through protein kinase C inhibition. It is currently in Phase II of clinical development for the prevention of acute rejection after solid organ transplantation. In renal transplant clinical trials, sotrastaurin has been ...

journal_title：Therapeutic drug monitoring

authors： Kovarik JM,Slade A

更新日期：2010-10-01 00:00:00

abstract：:The solubility and stability of amphotericin B in human serum in vitro was assessed using a sensitive high performance liquid chromatographic technique. The solubility of amphotericin B at concentrations ranging from 0.5 micrograms/ml to 10 micrograms/ml in human serum at pH 7.4, at 37 degrees C, and in 5% CO2 (simula...

journal_title：Therapeutic drug monitoring

authors： Edmonds LC,Davidson L,Bertino JS Jr

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To investigate the predictive value of the risperidone and venlafaxine metabolic ratios and CYP2D6 genotype. METHODS:The determination of risperidone, 9-hydroxyrisperidone, and venlafaxine, O-desmethylvenlafaxine, N-desmethylvenlafaxine and CYP2D6 genotype was performed in 425 and 491 patients, respectively. T...

journal_title：Therapeutic drug monitoring

authors： Mannheimer B,Haslemo T,Lindh JD,Eliasson E,Molden E

更新日期：2016-02-01 00:00:00

abstract：:Mixed-effect modeling has been suggested as a possible tool to detect and describe drug interactions in patient populations receiving drug combinations for the treatment of disease states. The mixed-effect modeling program, NONMEM, was used to measure the effects of the well-known digoxin-quinidine and digoxin-verapam...

journal_title：Therapeutic drug monitoring

authors： Bauer LA,Horn JR,Pettit H

更新日期：1996-02-01 00:00:00

abstract：:The pharmacokinetic interaction between chloroquine (CQ) and imipramine was investigated in six healthy volunteers who received 300 mg of CQ, 50 mg of imipramine, and combined doses of both drugs in a randomized, crossover design. Blood and urine samples were collected at predetermined time intervals and were analyzed...

journal_title：Therapeutic drug monitoring

authors： Onyeji CO,Toriola TA,Ogunbona FA

更新日期：1993-02-01 00:00:00

abstract：:Simplified pharmacokinetic methods have been used to estimate caffeine clearance in subjects with liver disease. There is a need to have a reliable, easy to implement method for research and possible clinical use. This study evaluates the use of Bayesian pharmacokinetic forecasting techniques to estimate caffeine clea...

journal_title：Therapeutic drug monitoring

authors： Denaro CP,Jacob P 3rd,Benowitz NL

更新日期：1998-02-01 00:00:00

abstract：:Atractyloside poisoning is an infrequent but often fatal form of herbal poisoning, which occurs worldwide but especially in Africa and the Mediterranean regions. The primary mechanism of atractyloside poisoning is known to be inhibition of the mitochondrial ADP transporter. Poisoning in humans may present with either ...

journal_title：Therapeutic drug monitoring

authors： Stewart MJ,Steenkamp V

更新日期：2000-12-01 00:00:00

abstract：:The monitoring of plasma olanzapine concentrations has been found to be an important and useful tool for optimizing psychiatric treatment. The present study investigated the effect that clinical factors, such as smoking and age, and functional polymorphisms of UGT1A4, CYP1A2, and CYP2D6 genes have on plasma olanzapine...

journal_title：Therapeutic drug monitoring

authors： Nozawa M,Ohnuma T,Matsubara Y,Sakai Y,Hatano T,Hanzawa R,Shibata N,Arai H

更新日期：2008-02-01 00:00:00

abstract：:To evaluate the reliability and practical use of saliva for therapeutic drug monitoring of the antifungal agent voriconazole in immunocompromised patients, a paired-sample study was conducted. Plasma and saliva trough levels were measured in seven children and nine adults who required treatment for the prevention or t...

journal_title：Therapeutic drug monitoring

authors： Michael C,Bierbach U,Frenzel K,Lange T,Basara N,Niederwieser D,Mauz-Körholz C,Preiss R

更新日期：2010-04-01 00:00:00

abstract：:A 64-year-old man with chronic renal insufficiency was hospitalized with dysphagia and inability to keep his head erect 11 months after beginning procainamide hydrochloride (PA) for control of atrial flutter. Evaluation revealed esophageal dysmotility, worsening renal function, and elevated serum PA and N-acetylprocai...

journal_title：Therapeutic drug monitoring

authors： Miller CD,Oleshansky MA,Gibson KF,Cantilena LR

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) time courses in serum and physiological and behavioral effects associated with smoking 1 or 4 "light cannabis" cigarettes were studied. Biomarkers to differentiate light cannabis versus illegal and medical cannabis use were also investigated. METHODS:Sera ...

journal_title：Therapeutic drug monitoring

authors： Pichini S,Mannocchi G,Berretta P,Zaami S,Pirani F,Pacifici R,Busardò FP

更新日期：2020-02-01 00:00:00

abstract：:Pentobarbital serum concentrations associated with a high-dose therapeutic regimen were determined using EMIT immunoassay reagents. Replicate analyses of serum controls resulted in a within-assay coefficient of variation of 5.0% and a between-assay coefficient of variation of 10%. Regression analysis of 44 serum sampl...

journal_title：Therapeutic drug monitoring

authors： Pape BE,Cary PL,Clay LC,Godolphin W

更新日期：1983-01-01 00:00:00