Determination of pentamidine in whole blood, plasma, and urine by high-performance liquid chromatography.

abstract：:The solubility and stability of amphotericin B in human serum in vitro was assessed using a sensitive high performance liquid chromatographic technique. The solubility of amphotericin B at concentrations ranging from 0.5 micrograms/ml to 10 micrograms/ml in human serum at pH 7.4, at 37 degrees C, and in 5% CO2 (simula...

journal_title：Therapeutic drug monitoring

authors： Edmonds LC,Davidson L,Bertino JS Jr

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The indication for the antiepileptic drug lacosamide (LCM) was recently extended to include children from the age of 4 years. Real-life data on the use and serum concentrations of LCM in children and adolescents are limited. The purpose of this study was to investigate the use of LCM in this patient group in...

journal_title：Therapeutic drug monitoring

authors： Larsen Burns M,Nikanorova M,Baftiu A,Borg Rasmussen J,Johannessen SI,Johannessen Landmark C

更新日期：2019-06-01 00:00:00

abstract：:A rapid and simple procedure based on gas chromatography-mass spectrometry (GC-MS) is described for determination of Delta-tetrahydrocannabinol (THC), 11-hydroxy-Delta-tetrahydrocannabinol (THC-OH) and 11-nor-Delta-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in meconium using Delta-tetrahydrocannabinol (Delta-TH...

journal_title：Therapeutic drug monitoring

authors： Marchei E,Pellegrini M,Pacifici R,Palmi I,Lozano J,García-Algar O,Pichini S

更新日期：2006-10-01 00:00:00

abstract：:Characterization of antibiotic pharmacokinetics in patients with renal insufficiency may be complicated by interfering substances within the assay. We compared three different assays for teicoplanin in serum and dialysate of 10 hemodialysis and six continuous ambulatory peritoneal dialysis (CAPD) patients. The microbi...

journal_title：Therapeutic drug monitoring

authors： Awni WM,St Peter WL,Guay DR,Kenny MT,Matzke GR

更新日期：1991-11-01 00:00:00

abstract：:OKT3 is a murine monoclonal antibody of the immunoglobulin IgG2a isotype. The target of OKT3, CD3, is a 17-20 kilodalton (kD) molecule that is part of a multimolecular complex found only on mature T cells and medullary thymocytes. This complex is uniquely situated next to the T-cell receptor for antigen. An interactio...

journal_title：Therapeutic drug monitoring

authors： Norman DJ

更新日期：1995-12-01 00:00:00

abstract：:Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Schwartz J,Martin M,Jauregui L

更新日期：1987-09-01 00:00:00

abstract：:The pharmacokinetics of rifampicin (RMP) and its principal active metabolite desacetylrifampicin (DA-RMP) were studied in six subjects, ranging in age from 78 to 95 years, after single oral doses of 10 mg/kg RMP. The maximal plasma concentrations (Cmax) and the elimination half-lives (t 1/2 beta) of RMP are 8.83 +/- 1...

journal_title：Therapeutic drug monitoring

authors： Advenier C,Gobert C,Houin G,Bidet D,Richelet S,Tillement JP

更新日期：1983-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is increasingly used for the treatment of autoimmune diseases (AID). In renal transplant recipients, it has been demonstrated that adjustment of the MMF dose according to the area under the plasma concentration versus time curve (AUC) of mycophenolic acid (MPA), the active moiety of MMF, im...

journal_title：Therapeutic drug monitoring

authors： de Winter BC,Neumann I,van Hest RM,van Gelder T,Mathot RA

更新日期：2009-06-01 00:00:00

abstract：:Australia is blessed with a great diversity of unique species in its fresh waters and in the marine environment around its coast. There is evidence that human and natural events are impacting on these species. Such impacts are associated with various agricultural, industrial, and domestic practices and with natural an...

journal_title：Therapeutic drug monitoring

authors： Moore MR,Shaw G

更新日期：2000-02-01 00:00:00

abstract：:Six groups of six male Wistar rats were administered methadone in their drinking water over the concentration range 0-0.25 mg/ml. Hair and trunk blood samples were collected after a 6-week period of drug administration. Immunoreactive methadone was measured by radioimmunoassay and methadone and its major metabolite, 2...

journal_title：Therapeutic drug monitoring

authors： Green SJ,Wilson JF

更新日期：1996-12-01 00:00:00

abstract：:During once-daily dosing regimens of aminoglycosides, administration of large single doses results in high peak levels and low 24-h trough levels. However, commercial assays for monitoring aminoglycoside levels are designed to cover the smaller range of serum concentrations usually observed during multiple daily dosin...

journal_title：Therapeutic drug monitoring

authors： Blaser J,König C,Fatio R,Follath F,Cometta A,Glauser M

更新日期：1995-04-01 00:00:00

abstract：:The effect of heparin sodium on the assay of gentamicin using the fluorescence polarization immunoassay system was investigated with varying heparin and gentamicin concentrations. Heparin had no significant effect on gentamicin concentrations as measured by this system. ...

journal_title：Therapeutic drug monitoring

authors： Jackson DS,Bertino JS Jr

更新日期：1984-01-01 00:00:00

abstract：:An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the oral antidiabetic tolbutamide and two of its metabolites, 4-hydroxytolbutamide and carboxytolbutamide, in human plasma and urine. The method was based on simple one-step liquid-liquid extraction with te...

journal_title：Therapeutic drug monitoring

authors： Hansen LL,Brøsen K

更新日期：1999-12-01 00:00:00

abstract：:An isocratic high-performance liquid chromatography method with amperometric detection for the assay of plasma salbutamol is described. The plasma extract is injected into the chromatographic system via a loop column. This insures the purification of the injected extracts and allows a simple and rapid liquid-solid ext...

journal_title：Therapeutic drug monitoring

authors： Tamisier-Karolak L,Delhotal-Landes B,Jolliet-Riant P,Milliez J,Jannet D,Barre J,Flouvat B

更新日期：1992-06-01 00:00:00

abstract：:Rapamycin (RAPA) is a new immunosuppressive drug with a potency similar to that of FK506 and up to a 100-fold greater than that of cyclosporine (CsA). RAPA has shown to be efficacious in the prolongation of allograft survival in a number of animal models. In early studies, RAPA was administered on a dose/weight basis,...

journal_title：Therapeutic drug monitoring

authors： Yatscoff RW,LeGatt DF,Kneteman NM

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Lacosamide (LCM) is one of the newer antiepileptic drugs (AEDs) licensed as add-on treatment for partial epilepsy. Data on LCM pharmacokinetics and interactions are limited and partly contradictory. The purpose of this study was to assess the effect of concomitant AED therapy on steady state plasma concentra...

journal_title：Therapeutic drug monitoring

authors： Contin M,Albani F,Riva R,Candela C,Mohamed S,Baruzzi A

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Busulfan (Bu) and cyclophosphamide (Cy) are frequently included in conditioning regimens before hematopoietic stem cell transplantation (HSCT). Both drugs are detoxified by glutathione transferases (GST), and GST gene variants may explain some of the interindividual variability in pharmacokinetics and drug t...

journal_title：Therapeutic drug monitoring

authors： Bremer S,Fløisand Y,Brinch L,Gedde-Dahl T,Bergan S

更新日期：2015-08-01 00:00:00

abstract：:Plasma levels of 6-mercaptopurine were determined in 22 consecutive children with acute lymphoblastic leukemia on oral remission maintenance therapy during the time period of August 1984 to January 1988. Each child received the drug once daily for up to 3 years and was studied repeatedly (1-12 times). An HPLC method w...

journal_title：Therapeutic drug monitoring

authors： Hayder S,Lafolie P,Björk O,Peterson C

更新日期：1989-11-01 00:00:00

abstract：:Individualized tobramycin therapy was systemically evaluated in 26 patients with gram-negative pneumonias involving Pseudomonas aeruginosa and other multiple antibiotic-resistant pathogens. Patient prognoses were classified by underlying diseases, and response was determined according to previously established criteri...

journal_title：Therapeutic drug monitoring

authors： Cipolle RJ,Seifert RD,Zaske DE,Strate RG

更新日期：1980-01-01 00:00:00

abstract：:Oral posaconazole (PSZ), an azole antifungal drug, was recently introduced for the treatment of invasive fungal infections. The prescription of PSZ together with the immunosuppressant tacrolimus (TRL) was evaluated in 14 lung transplant patients with cystic fibrosis. PSZ inhibited CYP3A4 TRL metabolism, resulting in a...

journal_title：Therapeutic drug monitoring

authors： Berge M,Chevalier P,Benammar M,Guillemain R,Amrein C,Lefeuvre S,Boussaud V,Billaud EM

更新日期：2009-06-01 00:00:00

abstract：:The current article describes a new assay to measure thiopurine methyltransferase (TPMT) activity from red blood cells. This method is based on the measurement of the reaction product 6-methylmercaptopurine (6-MMP) by high-performance liquid chromatography (HPLC). 6-MMP is extracted by ethyl acetate with recoveries of...

journal_title：Therapeutic drug monitoring

authors： Menor C,Fueyo JA,Escribano O,Cara C,Fernández-Moreno MD,Román ID,Guijarro LG

更新日期：2001-10-01 00:00:00

abstract：:For the accuracy of routine monitoring of digoxin and digitoxin it seems important to get information on the cross-reactivity of endogenous digitalis-like substances (EDLS). To obtain EDLS, urine was passed on Sep-Pak columns and eluted in fractions by increasing concentrations of acetonitrile. Dilution series of two ...

journal_title：Therapeutic drug monitoring

authors： Vinge E,Ekman R

更新日期：1988-01-01 00:00:00

abstract：:To develop a new method for quantifying fluoconazole in human plasma and to compare the bioavailability of two fluconazole capsule formulations, an open, randomized, two-period crossover study with a one-week washout interval was conducted in 24 healthy volunteers. Plasma samples were obtained up to 168 hours after dr...

journal_title：Therapeutic drug monitoring

authors： Moraes LA,Lerner FE,Moraes ME,Moraes MO,Corso G,De Nucci G

更新日期：1999-04-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is the first drug approved for the prevention of renal allograft rejection in the United States in the last 10 years. MMF is the morpholinoethyl ester of mycophenolic acid (MPA) and is a selective, reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme that is critic...

journal_title：Therapeutic drug monitoring

authors： Pirsch JD,Sollinger HW

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Serum trough concentrations as the sole means of monitoring safety and efficacy of vancomycin are insufficient. The daily area under the curve (AUC24) of serum concentration versus time to minimum inhibitory concentration (MIC) ratio of greater than 400 mg × h/L has emerged as a more robust dosing target. A ...

journal_title：Therapeutic drug monitoring

authors： Lewis P

更新日期：2018-06-01 00:00:00

abstract：:The binding characteristics of the antiepileptic agent and teratogen valproic acid for human serum and human placenta were investigated utilizing equilibrium dialysis of the drugs in serum and in homogenates of whole placenta so that the transplacental transfer of the drug could be better defined. A low-capacity, high...

journal_title：Therapeutic drug monitoring

authors： Bailey DN,Briggs JR

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Valproic acid (VPA) is frequently used together with clozapine (CLZ) as mood-stabilizer or for the prevention of seizures in patients with psychotic disorders. VPA is known to reduce levels of the pharmacologically active CLZ-metabolite N-desmethylclozapine (N-DMC), but factors determining the degree of this...

journal_title：Therapeutic drug monitoring

authors： Smith RL,Kyllesø L,Haslemo T,Andreassen OA,Molden E

更新日期：2019-08-01 00:00:00

abstract：:With the introduction of a cyclosporin monitoring strategy based on the use of a sample collected 2 hours after dosing (C2) rather than the predose sample (C0), there was concern that the differences in blood cyclosporin results from the various assay systems would result in assay-specific target ranges for C2 monitor...

journal_title：Therapeutic drug monitoring

authors： Johnston A,Chusney G,Schütz E,Oellerich M,Lee TD,Holt DW

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Ribavirin exposure after the first dose (D0AUC0-4h) >1755 mcg·h·L is predictive of sustained virological response (SVR) in patients with hepatitis C treated with peginterferon and ribavirin. The aim of this study was to test the benefit of ribavirin early dose adjustment based on this target in naïve patient...

journal_title：Therapeutic drug monitoring

authors： Loustaud-Ratti V,Maynard M,Thevenon S,Pradat P,Rousseau A,Alain S,Deny P,Gagnieu MC,Tran A,Dao T,Silvain C,Lunel-Fabiani F,Picard N,Zublena I,Marquet P,Trepo C,RIBAJUSTE Group.

更新日期：2016-12-01 00:00:00

abstract：:A computer-based approach for estimating pharmacokinetic data and predicting plasma drug concentrations based on two measurements of plasma drug concentrations was compared with a standard two-point method for estimating aminoglycoside (AG) pharmacokinetic parameters. The computer-based technique was also used to pred...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Pongsin V,Forney R Jr,Gronau G

更新日期：1985-01-01 00:00:00