Abstract:
:The short-term hemodynamic effects of molsidomine (4 mg sublingually) were evaluated in 13 patients with congestive heart failure following acute myocardial infarction. Right heart catheterization was performed by means of a Swan-Ganz thermodilution catheter. Hemodynamic measurements were made 30, 60, 120, and 180 minutes after the administration of the drug. Molsidomine significantly reduced systolic blood pressure from 121.5 +/- 3.3 (mean +/- SEM) to 111.1 +/- 2.9 mm Hg (p less than 0.001) after 60 minutes, mean right atrial pressure from 6.1 +/- 1 to 2.6 +/- 0.6 mm Hg (p less than 0.0001), mean pulmonary arterial pressure from 29.8 +/- 1.9 to 20.1 +/- 1.3 mm Hg (p less than 0.0001), and left ventricular filling pressure from 20.3 +/- 0.6 to 12.2 +/- 0.7 mm Hg (p less than 0.0001). No significant change occurred in heart rate, diastolic and mean blood pressure, cardiac index, stroke volume index, left ventricular stroke work index, systemic vascular resistance, and pulmonary vascular resistance. No side effects were seen after the administration of molsidomine.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Cantelli I,Lolli C,Brunelli A,Bracchetti Dsubject
Has Abstractpub_date
1985-03-01 00:00:00pages
716-9issue
3 Pt 2eissn
0002-8703issn
1097-6744pii
0002-8703(85)90690-8journal_volume
109pub_type
杂志文章abstract:BACKGROUND:Firm evidence exists for reduction in mortality and morbidity by lipid-lowering therapy in patients with coronary artery disease (CAD), yet a significant proportion remain untreated. This prospective study determined the effectiveness of a planned strategy of management using a cardiac rehabilitation nurse i...
journal_title:American heart journal
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更新日期:2001-12-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:American heart journal
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更新日期:2015-07-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:2011-12-01 00:00:00
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doi:10.1016/0002-8703(81)90033-8
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doi:10.1016/j.ahj.2020.10.057
更新日期:2021-01-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1067/mhj.2000.109979
更新日期:2000-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90353-1
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更新日期:2006-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-08-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.02.019
更新日期:2006-05-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
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更新日期:2016-09-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-10-01 00:00:00