Abstract:
BACKGROUND:Previous literature suggests an association between organochlorines and behavioral measures in childhood, including inattention. OBJECTIVE:This study was designed to assess whether prenatal organochlorine exposure is associated with measures of attention in early infancy. METHODS:We investigated an association between cord serum polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyl dichloroethene (DDE) levels and measures of attention from the Neonatal Behavioral Assessment Scale (NBAS) in a cohort of 788 infants born 1993-1998 to mothers residing near a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. RESULTS:Medians (ranges) for the sum of four prevalent PCB congeners and DDE levels were 0.19 (0.01-4.41) and 0.30 (0-10.29) ng/g serum, respectively. For the 542 subjects with an NBAS exam at 2 weeks, we observed consistent inverse associations between cord serum PCB and DDE levels and NBAS measures of alertness, quality of alert responsiveness, cost of attention, and other potential attention-associated measures including self-quieting and motor maturity. For example, the decrement in quality of alert responsiveness score was -0.51 (95% confidence interval, -0.99 to -0.03) for the highest quartile of exposure to the sum of four prevalent PCB congeners compared with the lowest quartile. We found little evidence for an association with infant orientation, habituation, and regulation of state, assessed as summary cluster measures. CONCLUSIONS:Our findings provide evidence for an association between low-level prenatal PCB and DDE exposures and poor attention in early infancy. Further analyses will focus on whether organochlorine-associated decrements in attention and attention-related skills in infancy persist in later childhood.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Sagiv SK,Nugent JK,Brazelton TB,Choi AL,Tolbert PE,Altshul LM,Korrick SAdoi
10.1289/ehp.10553subject
Has Abstractpub_date
2008-05-01 00:00:00pages
666-73issue
5eissn
0091-6765issn
1552-9924journal_volume
116pub_type
杂志文章abstract::Widespread and persistent organochlorine (OC) contaminants, such as polychlorinated biphenyls (PCBs) and pesticides, are known to have broad-ranging toxicities in wildlife. In this study we investigated, for the first time, their possible health effects on loggerhead sea turtles (Caretta caretta). Nonlethal fat biopsi...
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doi:10.1289/ehp.10168
更新日期:2007-10-01 00:00:00
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更新日期:1975-12-01 00:00:00
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pub_type: 杂志文章,meta分析
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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更新日期:1997-03-01 00:00:00
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更新日期:1994-01-01 00:00:00
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更新日期:2019-05-01 00:00:00
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更新日期:2005-08-01 00:00:00
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-04-01 00:00:00
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更新日期:2004-12-01 00:00:00
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更新日期:2015-05-01 00:00:00
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更新日期:1991-06-01 00:00:00
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更新日期:2018-01-11 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:The Love Canal is a rectangular 16-acre, 10-ft deep chemical waste landfill situated in a residential neighborhood in Niagara Falls, New York. This seriously contaminated site first came to public attention in 1978. No studies have examined mortality in the former residents of the Love Canal neighborhood (LC...
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更新日期:2009-02-01 00:00:00
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更新日期:2015-12-01 00:00:00
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更新日期:2003-05-01 00:00:00
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更新日期:1986-08-01 00:00:00
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更新日期:1986-12-01 00:00:00