Hodgkin's disease in childhood: the British National Lymphoma Investigation experience (BNLI Report No 27).

Abstract:

:The experience of the British National Lymphoma Investigation in the treatment of 68 children with Hodgkin's disease is reported over a 14 year period from 1970. The presenting histology was reviewed by a single histopathologist; 87% of the cases were classified as nodular sclerosis (NS) and further subdivided into NSI (53%) and NSII (35%). Primary treatment consisted of local (involved field) or prophylactic (extended field) irradiation, combination chemotherapy alone or low dose irradiation and chemotherapy. An overall 5 year survival of 87% was achieved and a 5 year relapse-free survival of 64%. Eight deaths were reported during the study, all of which occurred in children who presented with NSII histology. Each child was in relapse and undergoing chemotherapy at the time of death. This histological subtype was also associated with both a lower complete remission rate and a reduced response to second line chemotherapy.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Makepeace AR,Maclennan KA,Hudson GV,Jelliffe AM

doi

10.1016/s0009-9260(87)80382-3

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

7-11

issue

1

eissn

0009-9260

issn

1365-229X

journal_volume

38

pub_type

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