A pragmatic assessment of the British Thyroid Association "U classification" of thyroid nodules with a focus on their follow-up.

Abstract:

AIM:To assess the predictive value of the U classification and the significance of follow-up ultrasound in those managed conservatively. MATERIALS AND METHODS:A retrospective observational study was carried out among 1,465 patients who underwent thyroid ultrasound in 2016 at a teaching hospital in UK. Details regarding U classification of nodules, cytology, histology in patients who underwent surgery, and follow-up ultrasound in those managed conservatively were obtained. RESULTS:Thyroid surgery was performed in 129 patients of which malignancy was seen in 35 (27.1%). The proportion of patients with cancer in U1-U5 categories were 0%, 13.6%, 30.4%, 40%, and 100%, respectively (Fisher's exact test p=0.001). There was no significant difference in U stage, cytology, or histology between incidental and symptomatic nodules. Among patients who did not undergo surgery 5% of U1, 14.6% of U2, 75% of U3, and 71.4% of U4 underwent repeat ultrasound. Radiological progression in nodule size was seen in 4.2% of U1, 1.9% of U2, 0% of U3, and 40% of U4 nodules at median duration of 306, 439, 274, and 748 days, respectively. CONCLUSIONS:U classification is reliable in risk-stratifying thyroid nodules. Patients with benign nodules without high-risk features do not require follow-up. The interval between scans in patients with indeterminate nodules can be extended to a period of 6-12 months.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Arambewela MH,Wijesinghe AM,Randhawa K,Bull M,Wadsley J,Balasubramanian SP

doi

10.1016/j.crad.2020.02.012

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

466-473

issue

6

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(20)30081-7

journal_volume

75

pub_type

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