The management of generalised grade 2 non-Hodgkin's lymphomas (Report no 18).

Abstract:

:This report describes a comparison of combination chemotherapy (CHOP) with total body irradiation (TBI) in the management of Stages III and IV Grade 2 non-Hodgkin's lymphoma. This prospective randomised study was carried out by the BNLI between 1974 and 1978. One hundred and fourteen previously untreated patients were accepted: 66 received CHOP and 48 TBI. Complete remission was obtained in 39% of patients treated with CHOP and 23% with TBI. This difference is not significant. However, when comparison is stratified for Stage III disease the survival of the CHOP-treated group is statistically significant (chi(2) = 4.125: 0.05 greater than P greater than 0.025). This difference in favour of CHOP is most marked in patients with poorly differentiated histology. Only 46% of patients receiving CHOP remain alive at the time of this report. There is urgent need for more effective treatment in the management of this type of lymphoma.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Pettingale KW

doi

10.1016/s0009-9260(81)80186-9

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

553-6

issue

5

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(81)80186-9

journal_volume

32

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1994-04-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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