Abstract:
:MRI leukoaraiosis (LA) is less likely to interfere with simple compared to more complex working memory (WM) skills. We hypothesize that LA within the left hemisphere negatively impacts higher-level WM processes in dementia. Participants with dementia (n=64; MMSE=22.0+/-3.4) performed a Backward Digit Task measuring simple storage/rehearsal (ANY-ORDER) and complex disengagement/temporal re-ordering (SERIAL-ORDER) recall. A visual rating scale categorized MRI-LA in five regions per hemisphere: frontal and parietal centrum semiovale, white matter around the frontal horns, body of the lateral ventricles and posterior horns. Amidst equivalent hemispheric LA scores [t(62)=-1.12, p>0.05], correlations revealed an association between left-sided LA and SERIAL-ORDER recall (r=-0.31, p=0.007) with LA around the posterior horn (rho=-0.30, p=0.008) and frontal centrum semiovale (rho=-0.29, p=0.01) showing the greatest association. Regression modeling confirmed the left posterior horn contribution to SERIAL-ORDER performance variance. Results suggest involvement of anterior (fronto-striatal) and more posterior (inferior parietal) white matter tracts in higher order WM deficits in dementia.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Lamar M,Catani M,Price CC,Heilman KM,Libon DJdoi
10.1016/j.neuropsychologia.2008.04.007subject
Has Abstractpub_date
2008-08-01 00:00:00pages
2597-601issue
10eissn
0028-3932issn
1873-3514pii
S0028-3932(08)00125-5journal_volume
46pub_type
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