Abstract:
:Thirteen patients with intractable complex partial seizures of left temporal lobe origin were tested for verbal memory performance under the conditions of full and reduced anticonvulsant medication. As suggested by previous investigations memory performance improved significantly with the reduction of anticonvulsants. However, our observations refute assumptions that the effects of antiepileptic drugs act primarily by non-specific mechanisms affecting attention and/or memory diffusely. Our data rather suggest that very specific and circumscribed steps of verbal memory processing, particularly retrieval abilities after interference, are affected by anticonvulsants. The possible implications of these findings in relation to morphological and electrophysiological aspects in patients with temporal lobe epilepsy are discussed.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Durwen HF,Hufnagel A,Elger CEdoi
10.1016/0028-3932(92)90067-vsubject
Has Abstractpub_date
1992-07-01 00:00:00pages
623-31issue
7eissn
0028-3932issn
1873-3514journal_volume
30pub_type
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