Plasma lipids and composition of red cells in four cases of Werner's syndrome.

Abstract:

:Four cases of accelerated aging, known as Werner's syndrome (WS), are presented. Plasma lipid and lipoprotein findings and lipid compositions of red cell membranes are compared to those of old and young healthy people. Typical clinical findings, as reported in the literature, confirmed the diagnosis. Furthermore, an elevated osmotic fragility of red blood cells (RBC) was observed. RBC membranes of WS patients showed phospholipid concentrations similar to those found in people aged over 70 years, which have been reported to be lower than those of mature donors aged below 30 years. Fatty acid patterns of RBC membranes and plasma phospholipids were indicative of some disturbance in phospholipid subclass distributions in WS-patients.

journal_name

Arch Gerontol Geriatr

authors

Brosche T,Bauer M,Platt D,Ruprecht KW,Rieck W

doi

10.1016/0167-4943(86)90023-3

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

207-20

issue

3

eissn

0167-4943

issn

1872-6976

pii

0167-4943(86)90023-3

journal_volume

5

pub_type

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