Abstract：
:The cytotoxic activity of natural killer (NK) cells under both basal and interferon (IFN)-induced conditions, as well as the proliferative response of lymphocytes to ConA in old rats treated in vivo with AL-721 have been analyzed. The low levels of basal NK cell activity present in spleen of old rats were completely recovered to the levels of NK cytotoxicity obtained in young rats in animals treated in vivo with AL-721. Similar results were obtained for in vitro IFN-boosting of NK cells, in so far as the reduced IFN-responsiveness of NK cells from old untreated rats was restored to the levels of IFN-induced young NK activity in animals treated in vivo with AL-721. The evaluation of the proliferative response of lymphocytes to ConA revealed that old rats treated in vivo with AL-721 showed an increased proliferative capacity in comparison to old untreated animals even if the mitogenic response was not recovered up to the levels observed in young rats.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Provinciali M,Di Stefano G,Pieri C,Fabris Ndoi
10.1016/s0167-4943(05)80030-5subject
Has Abstractpub_date
1992-01-01 00:00:00pages
303-10eissn
0167-4943issn
1872-6976pii
S0167-4943(05)80030-5journal_volume
15 Suppl 1pub_type
杂志文章abstract：:Though frailty status has recently been linked to poorer quality of life, the impact of income on this relationship has not previously been investigated. Data from a population-based panel study, the English Longitudinal Study of Aging, on 3225 participants aged 65-79 years were analyzed cross-sectionally. A Frailty I...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.12.008
更新日期：2014-05-01 00:00:00
abstract：:This study explored the association between vitamin D insufficiency and frailty syndrome defined by the Fried Frailty Index (FFI) and the Edmonton Frail Scale (EFS) in a northern Taiwan community. Data of 215 subjects participating in an integrated interventional trial involving community-dwelling older adults with a ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/S0167-4943(10)70006-6
更新日期：2010-02-01 00:00:00
abstract：:The demands of long-term care facilities (LTCFs) residents are complex which usually require a range of professionals and caregivers to provide treatment and care. To reduce this fragmentation of care, integrated care models are developed in modern health care system, and a gradual change from traditional LTCF care to...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2009.05.004
更新日期：2010-05-01 00:00:00
abstract：:Statistical data of Italy, issued on 1st January 2005, show that Tuscany has a high percentage of elderly subjects, and that to reach 100 years is a common possibility, mainly for women. Comparable values appear for longevity index (LI%), either calculated on the basis of the various resorts above sea level, or on the...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2008.02.002
更新日期：2009-03-01 00:00:00
abstract：:A randomised controlled trial was conducted to assess whether a single intervention by a health visitor reduced the unplanned re-admission of elderly people discharged from geriatric wards. Two hundred and four consecutive discharges from geriatric wards were randomly allocated to receive either a single visit from th...
journal_title：Archives of gerontology and geriatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-4943(94)90044-2
更新日期：1994-01-01 00:00:00
abstract：:Osteoarthritis is a degenerative joint disease characterized by destruction of the articular cartilage in aging and senescence. The aim of this study was to study the possible treatment of this disease by intraarticular injection of growth factors to osteoarthritic joints of aged animals. 20-month-old female ICR mice ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(00)00079-0
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Falls are the leading cause of fatal injury in geriatric patients. Nursing home falls occur at twice the rate of community falls, yet few studies have compared these groups. We hypothesized that nursing home residents admitted for fall would be sicker than their community counterparts on presentation and hav...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.12.002
更新日期：2016-03-01 00:00:00
abstract：:The association between adverse health and loneliness among aging people is known, but most of the studies are cross-sectional. In addition, the associations between changes in loneliness with health are less well known, especially in the case of aging people. The present study examined whether absence of loneliness i...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.023
更新日期：2011-09-01 00:00:00
abstract：:Psychotic symptoms such as hallucinations, delusions and confusion are well known side-effects of levodopa (LD) therapy of Parkinson's disease (PD), even if there is much confusion regarding the variability of the psychotic manifestations. We studied 18 patients clinically treated with LD associated with an inhibitor ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(96)86915-9
更新日期：1996-01-01 00:00:00
abstract：:According to the 'Hayflick limit', human fetal fibroblasts have a uniform, limited replicative lifespan of about 50 population doublings in cell culture. This concept was extrapolated to diverse cells in the body. It seemed to decrease with the age of the cell donor and, as a form of cell senescence, was thought to un...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00221-7
更新日期：2002-05-01 00:00:00
abstract：:Studies on the relationship between behavioral competence, such as the competence of exerting out-of-home behavior (OOHB), and well-being in older adults have rarely addressed cognitive status as a potentially moderating factor. We included 35 persons with early-stage dementia of the Alzheimer's type (DAT), 76 individ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2014.03.015
更新日期：2014-07-01 00:00:00
abstract：:There are still conflicting results regarding the association between grip and global muscle strength in older people. Therefore, the objective of the present study was to determine the association between grip strength and global muscle strength, as well as between grip strength and individual trunk, hip, knee and an...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2019.03.005
更新日期：2019-01-01 00:00:00
abstract：:Obesity has gained a great importance during the last decades, and this fact stimulated numerous studies regarding the genetic causes of this disease. A recently discovered new molecule, called leptin, raised a wide interest. It is a product of the adipocytes, it exerts inhibitory effects on the center of appetite and...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00195-9
更新日期：2002-02-01 00:00:00
abstract：:Although an association between SA concentrations and mortality in the patients is well known, this association is not conclusive in elderly community-dwelling populations. We therefore attempted to determine whether this association could be extended to a Japanese 70-year-old community-dwelling population. Seventy-ye...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.02.018
更新日期：2012-01-01 00:00:00
abstract：:Hypothyroidism is a common disorder in older people, and may be asymptomatic and hard to be diagnosed. The main purpose of this study was to evaluate the distribution of serum thyrotropin (thyroxin-stimulating hormone, TSH) among asymptomatic older people in Taiwan, and to evaluate the relationship between age and ser...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2009.09.004
更新日期：2010-09-01 00:00:00
abstract：:The experimental suitability of the flour beetles of the genus Tribolium has attracted ecologists, nutritionists, radiation biologists and geneticists for decades. I have, recently, evaluated their importance to gerontologists. This paper deals with age-related changes and parental age effects which were not included ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(87)90038-0
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:Amnesic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease. Given the absence of an effective pharmacological treatment for aMCI, increasing numbers of studies are attempting to understand how cognitive interventions could benefit aMCI patients. The aim of this systematic...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/j.archger.2020.104332
更新日期：2021-01-14 00:00:00
abstract：:This study was aimed to determine the pain, physical performance and balance conditions of the elderly hospitalized in university hospital geriatric wards. The reasons for hospitalization and co-morbid diseases were recorded. Severity of pain was assessed on a visual analogue scale. Activity independence ability was t...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.08.002
更新日期：2011-05-01 00:00:00
abstract：:Changes in body composition, including a decrease in muscle and bone mass, accompany aging. Our aim was to assess the prevalence of sarcopenia and its association with osteoporosis in hip-fracture women. We performed a Dual-Energy X-Ray Absorptiometry (DXA) scan in 313 of 340 women, 20.9 ± 6.5 (mean ± S.D.) days after...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.02.002
更新日期：2011-01-01 00:00:00
abstract：AIMS:Type 2 Diabetes Mellitus(DM) is a well-known risk factor for cognitive impairment. Recent evidences suggest that Dipeptidyl peptidase-4(DPP-4) inhibitors might have neuroprotective effects. Therefore, this study aimed to investigate vildagliptin, a DPP-4 inhibitor, effects on cognitive function in older patients w...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104013
更新日期：2020-01-01 00:00:00
abstract：:Assessment of suffering is extremely important in dying end-stage dementia patients (ESDP). We have developed and examined the reliability and validity of the Mini-Suffering State Examination (MSSE), in 103 consecutive bedridden ESDP. Main outcome measures included inter-observer reliability and concurrent validity. R...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2003.08.007
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:The phenomenon of empty-nest older adults has raised growing concerns in contemporary Chinese society. In this study, we examined the prevalence and related influencing factors of depression symptoms among empty-nest older adults in China at a national level. METHODS:The database of the 2015 China Health an...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104183
更新日期：2020-07-21 00:00:00
abstract：:The purpose of this study was to evaluate the validity and reproducibility of the modified lateral functional reach (FR), and to examine the associations between a variety of functional variables and the FR in community-dwelling older people (>65 years of age). A total of 383 aged Japanese participated in this study a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2005.06.010
更新日期：2006-03-01 00:00:00
abstract：:The objective of this study was to evaluate the effects of growth and aging on the antioxidant capacities of rat serum and brain, by using two different reactive oxygen species (ROS) generators and two different methods of expressing the results. The antioxidant capacity was determined by using the oxygen radical abso...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(95)00674-5
更新日期：1996-01-01 00:00:00
abstract：:In a super-aged society, the need for prevention of locomotor dysfunction is growing, and evidence for feasible preventive measures is thus required. This study aimed to examine the relationship between these disorders and the prevalence rates for falling and physical function status. Participants included 1182 commun...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.05.005
更新日期：2013-11-01 00:00:00
abstract：:Behavioral and psychological signs of dementia (BPSD) are common clinical characteristics of Alzheimer's disease (AD). They result in patient and caregivers distress, decreased quality of life and placement in nursing homes. Treatment of BPSD with antidepressant and antipsychotic medications is not without complicatio...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00187-x
更新日期：2001-11-01 00:00:00
abstract：:The effects of idebenone, a cerebral metabolic enhancer, on learning and memory impairment in two rat models with central cholinergic or serotonergic dysfunction were investigated using positively reinforced learning tasks. A delayed alternation task using a T maze was employed to test the effect of idebenone on short...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(89)90005-8
更新日期：1989-05-01 00:00:00
abstract：:As the population is ageing, health promotion is becoming increasingly important to prevent disease and disability. Cigarette smoking is strongly associated with excess mortality and smoking cessation even after the age of 65 years, improves health and lowers mortality. The voluntary sector is an under-utilised resour...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00212-6
更新日期：2002-07-01 00:00:00
abstract：:Colorectal cancer is predominantly a disease of elderly people, since over 70% of cases occur in those aged 65 years or older. Clinicians have to frequently decide whether major surgery is justified in elderly patients with a limited life expectancy. Our retrospective study was aimed to compare outcomes of primary sur...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2005.02.001
更新日期：2005-09-01 00:00:00
abstract：:Insomnia is a significant problem that may jeopardize elderly residents' quality of life in long-term care settings. However, there are only a few studies dealing with sleeping disturbances among nursing home residents. The goal of this study was to determine the prevalence of insomnia and its associated factors in nu...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2005.06.008
更新日期：2006-01-01 00:00:00
