Abstract：
AIMS:Type 2 Diabetes Mellitus(DM) is a well-known risk factor for cognitive impairment. Recent evidences suggest that Dipeptidyl peptidase-4(DPP-4) inhibitors might have neuroprotective effects. Therefore, this study aimed to investigate vildagliptin, a DPP-4 inhibitor, effects on cognitive function in older patients with DM. MATERIALS AND METHODS:A retrospective longitudinal clinical trial was carried out on total 130 subjects with type 2 DM. Patients underwent comprehensive geriatric assessment twice within six months interval. The patients were divided into three groups according to antidiabetic treatment: untreated control group (patients achieve individual goal HbA1c without antidiabetic medication), vildagliptin(+) group(patients using vildagliptin alone or combination) and the vildagliptin(-) group. RESULTS:The mean age was 75.72 ± 7.46 years. The control group was older, of a lighter weight and also had a higher female gender ratio(p ≤ 0.01). When sex, age, educational level and metabolic profile were adjusted, there was only change in copying subdomain of Mini Mental State Examination between vildagliptin(+) and other groups at the end of 6 months. Vildagliptin also resulted in reduction of HbA1c and weight(p < 0.05). CONCLUSION:The addition of vildagliptin to treatment improved the copying subdomain of cognitive function and metabolic control of the older patients with type 2 DM within 6 months.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Ates Bulut E,Sahin Alak ZY,Dokuzlar O,Kocyigit SE,Soysal P,Smith L,Isik ATdoi
10.1016/j.archger.2020.104013subject
Has Abstractpub_date
2020-01-01 00:00:00pages
104013eissn
0167-4943issn
1872-6976pii
S0167-4943(20)30007-8journal_volume
88pub_type
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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