Idebenone improves learning and memory impairment induced by cholinergic or serotonergic dysfunction in rats.


:The effects of idebenone, a cerebral metabolic enhancer, on learning and memory impairment in two rat models with central cholinergic or serotonergic dysfunction were investigated using positively reinforced learning tasks. A delayed alternation task using a T maze was employed to test the effect of idebenone on short-term memory impairment induced by a cholinergic antagonist, scopolamine. A correct response, defined as a turn toward the arm opposite to that in the forced run, was rewarded with food pellets. Scopolamine (0.2 and 0.5 mg/kg, i.p.) significantly decreased the correct responses to the chance level in the 60-s-delayed alternation task. The scopolamine (0.2 mg/kg, i.p.)-induced impairment of short-term memory was improved by idebenone (3-30 mg/kg, i.p.) or an acetylcholinesterase inhibitor, physostigmine (0.1 and 0.2 mg/kg, i.p.), administered simultaneously. The central serotonergic dysfunction model was produced by giving rats a diet deficient in tryptophan, a precursor of serotonin. The rats fed on a tryptophan-deficient diet (TDD) showed a slower learning process in the operant brightness discrimination task (mult V115 EXT) than did rats fed on a normal diet. Idebenone (60 mg/kg/day) admixed with the TDD decreased the number of lever-pressing responses emitted during the extinction periods. The percentage of correct responses was significantly higher in the idebenone-treated group than in the control TDD group. These results suggest that idebenone may improve both the impairment of short-term memory induced by a decreased cholinergic activity and the retardation of discrimination learning induced by central serotonergic dysfunction.


Arch Gerontol Geriatr


Yamazaki N,Nomura M,Nagaoka A,Nagawa Y




Has Abstract


1989-05-01 00:00:00














  • Hand tactile discrimination, social touch and frailty criteria in elderly people: A cross sectional observational study.

    abstract::Frailty is a common syndrome among elderly and sensory decline may exacerbate functional decline. The hand function, the manual dexterity, the performance of the daily living skills and the social interactions are determined, in a large degree, by sensory integrity. However, hand tactile sensory deterioration has been...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Vieira AI,Nogueira D,de Azevedo Reis E,da Lapa Rosado M,Vânia Nunes M,Castro-Caldas A

    更新日期:2016-09-01 00:00:00

  • The relation between cognitive function and UI in healthy, community-dwelling, middle-aged and elderly people.

    abstract::The aim of this study was to examine the relation between UI and cognitive function among non-disabled middle-aged and elderly community-dwelling people. A total of 201 participants (86 men and 115 women) were given a structured questionnaire regarding their condition of UI as well as a cognitive assessment battery (m...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Hatta T,Iwahara A,Ito E,Hatta T,Hamajima N

    更新日期:2011-09-01 00:00:00

  • Life events and their impact on health attitudes and health behavior.

    abstract::A representative sample of non-institutionalized elderly persons between 65 and 74 years living in Stockholm county, Sweden responded to a self-report health questionnaire. Special life events and their subsequent effects were examined in the context of health attitudes and health behavior. Of the 370 respondents, 128...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Andersson L,Stanich J

    更新日期:1996-09-01 00:00:00

  • Relationship between employment status and obesity in a Korean elderly population, based on the 2007-2009 Korean National Health and Nutrition Examination Survey (KNHANES).

    abstract::We investigated the relationship between employment status and obesity prevalence in an elderly Korean, using a nationally representative sample. This cross-sectional study included 2991 participants (1396 men and 1595 women) aged 60 years or older. Employment status was categorized into full-time employees, part-time...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Kang HT,Lee HR,Lee YJ,Linton JA,Shim JY

    更新日期:2013-07-01 00:00:00

  • The enduring effect of education-socioeconomic differences in disability trajectories from age 85 years in the Newcastle 85+ Study.

    abstract:OBJECTIVE:Little is known about disability progression in very old age despite this being vital for care planning. We investigate whether distinct trajectories of disability are evident from age 85 to 90 and their association with socio-economic status (SES). METHODS:The Newcastle 85+ Study recruited people born in 19...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Kingston A,Davies K,Collerton J,Robinson L,Duncan R,Kirkwood TB,Jagger C

    更新日期:2015-05-01 00:00:00

  • Implication of the G145C polymorphism (rs713598) of the TAS2r38 gene on food consumption by Brazilian older women.

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Colares-Bento FC,Souza VC,Toledo JO,Moraes CF,Alho CS,Lima RM,Cordova C,Nobrega OT

    更新日期:2012-03-01 00:00:00

  • Functional, balance and health determinants of falls in a free living community Amazon riparian elderly.

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Maia Ribeiro EA,Ribeiro EE,Viegas K,Teixeira F,dos Santos Montagner GF,Mota KM,Barbisan F,da Cruz IB,de Paz JA

    更新日期:2013-03-01 00:00:00

  • Treatment of community-onset methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: a hospital-based study.

    abstract::S. aureus bacteremia (SAB) is a severe systemic illness, which is associated with high mortality and healthcare cost. It has been reported that older age per se is a poor prognostic factor of SAB, but little is known whether poor clinical outcomes is related to conservative attitudes of treating physicians. A retrospe...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Chen LY,Chen LK,Chang CW,Kuo SC,Li LF,Chan YJ,Wang FD

    更新日期:2012-07-01 00:00:00

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    abstract::As Taiwan has become the fastest aging country in the world, developing elderly-friendly health care services is of great importance. Compared with traditional health-care service models, healthcare needs of older people may differ extensively. It has been reported that geriatric evaluation and management (GEM), helps...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Lin MH,Liu CL,Peng LN,Chen YT,Chen LK

    更新日期:2012-07-01 00:00:00

  • The evaluation of carotid stenosis as risk factor for stroke in hypertensive diabetic and non-diabetic patients.

    abstract::The evaluation of intima-media thickening (IMT) of carotid artery is an important parameter in preclinical diagnosis of atherosclerosis and stroke risk in hypertensive patients. Measurements of carotid wall thickness via Doppler were considered to be valuable in prediction of risk of brain damage and future stroke due...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Revnic CR,Popa C,Nica AS,Ginghina C,Revnic F

    更新日期:2007-01-01 00:00:00

  • Physiological and psychosocial factors in spiritual needs attainment for community-dwelling older adults.

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章,多中心研究


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    更新日期:2018-01-01 00:00:00

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    abstract::Individual differences are the hallmark of aging. Chronological age (CHA) is known that fails to provide an accurate indicator of the aging but biological age (BA) estimates the functional status of an individual in reference to his or her chronological peers on the basis of how well he or she functions in comparison ...

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Bae CY,Kang YG,Kim S,Cho C,Kang HC,Yu BY,Lee SW,Cho KH,Lee DC,Lee K,Kim JS,Shin KK

    更新日期:2008-09-01 00:00:00

  • Evaluation of quality of life (QoL) of students of the University of Third Age (U3A) on the basis of socio-demographic factors and health status.

    abstract::In times of the modern global societies, concern for QoL is a priority for gerontology, being an interdisciplinary field. The aim of this study was to assess the QoL of students of the U3A based on socio-demographic factors, subjectively reported diseases and/or discomfort, and well-being. The study comprised 257 stud...

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    pub_type: 杂志文章


    authors: Zielińska-Więczkowska H,Kędziora-Kornatowska K,Ciemnoczołowski W

    更新日期:2011-09-01 00:00:00

  • Instruments to evaluate mobility capacity of older adults during hospitalization: A systematic review.

    abstract::Independent mobility is a key factor in predicting morbidity and determining hospital discharge readiness for older patients. The main objective was identify and appraise relevant instruments for the measurement of mobility of hospitalized geriatric patients. A systematic review was performed in two consecutive steps....

    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章,评审


    authors: Soares Menezes KVR,Auger C,de Souza Menezes WR,Guerra RO

    更新日期:2017-09-01 00:00:00

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Magnone MC,Rossolini G,Piantanelli L,Migani P

    更新日期:2000-06-01 00:00:00

  • Accidents of the elderly living in Kocaeli Region (Turkey).

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    journal_title:Archives of gerontology and geriatrics

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    authors: Acimis NM,Mas N,Yazici AC,Gocmen L,Isik AT,Mas MR

    更新日期:2009-09-01 00:00:00

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Wei M,Li J,Wang H

    更新日期:2018-01-01 00:00:00

  • Visual dependence affects the motor behavior of older adults during the Timed Up and Go (TUG) test.

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    journal_title:Archives of gerontology and geriatrics

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    authors: Almajid R,Tucker C,Wright WG,Vasudevan E,Keshner E

    更新日期:2020-01-01 00:00:00

  • Sex-differences in relation to the association between patterns of physical activity and sedentary behavior with frailty.

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    journal_title:Archives of gerontology and geriatrics

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章,随机对照试验


    authors: Karadag B,Ozulu B,Ozturk FY,Oztekin E,Sener N,Altuntas Y

    更新日期:2011-03-01 00:00:00

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Niu S,Tian S,Lou J,Kang X,Zhang L,Lian H,Zhang J

    更新日期:2020-01-01 00:00:00

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Granito RN,Aveiro MC,Renno AC,Oishi J,Driusso P

    更新日期:2012-03-01 00:00:00

  • Comparison of sarcopenic status between elderly leprosy survivors and general population.

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Kim W,Park HW,Hwang BK,Bae SO,Kim IK,Chung SG

    更新日期:2014-01-01 00:00:00

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Smith R,Drennan V,Mackenzie A,Greenwood N

    更新日期:2018-01-01 00:00:00

  • Calcium antagonist flunarizine hydrochloride affects striatal D2 dopamine receptors in the young adult and aged rat brain.

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    pub_type: 杂志文章


    authors: Asanuma M,Ogawa N,Haba K,Hirata H,Mori A

    更新日期:1991-11-01 00:00:00

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Lucantoni C,Lanza R,Campanari G,Amadio L

    更新日期:1983-12-01 00:00:00

  • Home modification by older adults and their informal caregivers.

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Kim H,Ahn YH,Steinhoff A,Lee KH

    更新日期:2014-11-01 00:00:00

  • Prospective associations of osteosarcopenia and osteodynapenia with incident fracture and mortality over 10 years in community-dwelling older adults.

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Balogun S,Winzenberg T,Wills K,Scott D,Callisaya M,Cicuttini F,Jones G,Aitken D

    更新日期:2019-01-01 00:00:00

  • Loneliness in elderly individuals, level of dependence in activities of daily living (ADL) and influential factors.

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章,多中心研究


    authors: Hacihasanoğlu R,Yildirim A,Karakurt P

    更新日期:2012-01-01 00:00:00

  • Clinical frailty scale and mortality in COVID-19: A systematic review and dose-response meta-analysis.

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    journal_title:Archives of gerontology and geriatrics

    pub_type: 杂志文章


    authors: Pranata R,Henrina J,Lim MA,Lawrensia S,Yonas E,Vania R,Huang I,Lukito AA,Suastika K,Kuswardhani RAT,Setiati S

    更新日期:2020-12-15 00:00:00