Abstract：
:Dehydroepiandrosterone sulfate (DHEAS) is the most abundant circulating steroid hormone in humans and can readily be converted to its parent steroid DHEA by tissue sulfatases. Yet, a biologic function for these steroids has not been defined. The link between DHEA and aging has been raised by: (1) its well documented age-related decline, and (2) a preventive effect of DHEA on numerous age-related illnesses: ischemic heart-disease, cognitive impairment, immunodeficiency, malignancies, osteoporosis. These effects have been suggested by epidemiological studies in humans. Animal studies support a protective effect of DHEA on these age-related diseases. However, it remains unknown whether these results in animals can be transposed in humans, because adrenal secretion of DHEA seems to be particular to primates. In humans, only a few studies have been performed. The effects of oral supplementation with DHEA have, so far, focused on the possible metabolic effects of DHEA. A few studies have shown: the absence of any side-effects; no change in body-weight; conflicting results on body-composition and lipids and no effect on insulin-tolerance. The latest study showed a beneficial effect on well-being but these results need to be confirmed.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Barrou Z,Charru P,Lidy Cdoi
10.1016/s0167-4943(96)00761-3subject
Has Abstractpub_date
1997-05-01 00:00:00pages
233-41issue
3eissn
0167-4943issn
1872-6976pii
S0167-4943(96)00761-3journal_volume
24pub_type
杂志文章abstract：:In a super-aged society, the need for prevention of locomotor dysfunction is growing, and evidence for feasible preventive measures is thus required. This study aimed to examine the relationship between these disorders and the prevalence rates for falling and physical function status. Participants included 1182 commun...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.05.005
更新日期：2013-11-01 00:00:00
abstract：:We aimed to examine the validity of fall risk assessment items for the healthy community-dwelling elderly Japanese population. Participants were 1122 healthy elderly individuals aged 60 years and over (380 males and 742 females). The percentage who had experienced a fall was 15.8%. This study used fall experience and ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.010
更新日期：2011-07-01 00:00:00
abstract：:Epidemiological studies have described the association between physical fitness and health. Few have reported the impact of seasonal variation on fitness determinants, in elderly. We investigated the effects of summer and winter environmental conditions on physical fitness, in both exercise and non-exercise elders. 37...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2018.02.008
更新日期：2018-01-01 00:00:00
abstract：:The interference of a chronic disease on the aging process reduces patients efficiency in confronting everyday life events and their Quality of Life (QOL). The purpose of this study was to examine the interaction between cognitive problems and emotional difficulties as related to several chronic diseases commonly pres...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(95)00693-1
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:We studied whether entrance-related environmental barriers, perceived and objectively recorded, were associated with moving out-of-home daily in older people with and without limitations in lower extremity performance. METHODS:Cross-sectional analyses of the "Life-space mobility in old age" cohort including 84...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2016.11.011
更新日期：2017-01-01 00:00:00
abstract：:Independent mobility is a key factor in predicting morbidity and determining hospital discharge readiness for older patients. The main objective was identify and appraise relevant instruments for the measurement of mobility of hospitalized geriatric patients. A systematic review was performed in two consecutive steps....
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/j.archger.2017.05.009
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:The purpose of this study was to identify the effects of plantar perception training using a hardness discrimination task on balance and falls efficacy of the elderly who have experienced a fall. MATERIALS AND METHODS:Sixty-two elderly persons 65 years of age or older were randomly allocated to the experimenta...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2018.03.014
更新日期：2018-01-01 00:00:00
abstract：:Two hundred and fifty-six carers of elderly people aged 70 and over were questioned on their attitudes towards their caring role and their preferences for their own future care. Despite the fact that most were providing assistance at high personal cost, most cares were highly committed to their caring role. However, t...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(92)90050-e
更新日期：1992-03-01 00:00:00
abstract：:Few studies have explored the associations of reported PA (RPA) with the processes underlying the development of disability. The present study was performed to explore RPA among older persons and its association with onset of functional dependence and mortality. Among a probability sample of 1782 community-living pers...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.06.024
更新日期：2012-07-01 00:00:00
abstract：:Using data from the Chinese Longitudinal Health Longevity Survey of 2005, 2008 and 2011, the authors compared the difference in the disability trajectory (DT) of survivor, decedent and dropped-out survey respondents and examined gender differences in DT using a group-based trajectory model, gender differences in the i...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2017.10.015
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:Since the outbreak of 2019 novel coronavirus (COVID-19), which has spread in the world rapidly. Population have a susceptibility to COVID-19, older people were more susceptible to have a variety diseases than younger, including COVID-19 infection with no doubt. This study focused on older patients with COVID...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104058
更新日期：2020-01-01 00:00:00
abstract：:Serum concentrations of C-reactive protein (CRP), interleukin-6 (Il-6) and tumor necrosis factor-alpha (TNF-alpha), as well as body mass index (BMI) were measured in a series of 36 elderly subjects (18 males, 18 females) of mean age 76.8+/-4.5 years, in order to assess whether these parameters are involved in senile o...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(98)00110-1
更新日期：1998-09-01 00:00:00
abstract：:Motor dysfunction increases in the moderate and severe stages of dementia. However, there is still no consensus on changes in mobility during its early stages. This meta-analysis aimed to measure the level of single-task functional mobility in older subjects with mild cognitive impairment (MCI) and/or Alzheimer's dise...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,meta分析
doi：10.1016/j.archger.2019.103941
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Depression, anxiety, and cognitive impairments occur in up to 40 % of adults with AF and are associated with poorer health-related quality of life (HRQoL) and higher symptom burden. However, it is unknown how often these impairments co-occur, or multimorbidity, and how multimorbidity effects HRQoL and sympto...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104117
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:With the aging phenomenon, there is growing interest in developing effective strategies to counteract dynapenia, the age-related loss of muscle strength. The positive effect of progressive resistance training on muscle strength is well known, however, the effect of nutritional supplementation or its synergis...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2020.104098
更新日期：2020-01-01 00:00:00
abstract：:This report assesses associations between trajectories of psychosocial experience over the life course and cognitive function in late life men. Survey data from the National Longitudinal Study of Older Men, a community sample of 1835 United States men aged 45-59 years in 1966, are used to explore the cognitive effects...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(03)00046-3
更新日期：2003-09-01 00:00:00
abstract：:An augmented home help service was set up in the Rhondda Valley in South Wales in order to facilitate discharge from hospital of elderly subjects who were kept in hospital because of mainly social problems. Patients were allocated to the new service or the pre-existing services according to their date of birth. The ex...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(88)90023-4
更新日期：1988-03-01 00:00:00
abstract：:The study was to compare the ability of BMI, MAC and CC in predicting nutritional status, functional ability and follow-up mortality risk of older adults. The study purposively recruited 160 of 320 residents of a nursing home in Central Taiwan to serve as subjects. Residents who were ≥65 years old, cognitively normal,...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.05.015
更新日期：2012-05-01 00:00:00
abstract：:Statistical data of Italy, issued on 1st January 2005, show that Tuscany has a high percentage of elderly subjects, and that to reach 100 years is a common possibility, mainly for women. Comparable values appear for longevity index (LI%), either calculated on the basis of the various resorts above sea level, or on the...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2008.02.002
更新日期：2009-03-01 00:00:00
abstract：:The association between adverse health and loneliness among aging people is known, but most of the studies are cross-sectional. In addition, the associations between changes in loneliness with health are less well known, especially in the case of aging people. The present study examined whether absence of loneliness i...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.023
更新日期：2011-09-01 00:00:00
abstract：:The nutritional assessment of the elderly shows several interpretative difficulties due to the lack of standard parameters. Moreover chronic age-related diseases can interfere with the physiological nutritional status. Anthropometric (triceps skinfold, arm muscle area, total body muscle mass, fat mass and Body Mass In...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(94)00578-u
更新日期：1995-03-01 00:00:00
abstract：:The BMS is a common chronic pain condition which mainly affects old women. The high prevalence of oral parafunctional habits and dry mouth symptoms in patients with BMS suggests that inflammation at the subclinical level due to repetitive microtrauma may cause burning mouth sensations. In this study, using a comprehen...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2009.08.008
更新日期：2010-07-01 00:00:00
abstract：:The onset of delirium is frequent in elderly patients who sustain hip fractures. The purpose of this study was to characterize different patterns of preoperative and postoperative delirium, to study factors associated with preoperative delirium and to evaluate the possible different outcome of these patients. This ret...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(02)00058-4
更新日期：2003-01-01 00:00:00
abstract：:The authors investigated elderly people's ability to benefit from specific memory training. Empirical evidence of cognitive aging shows a deterioration in working memory ability but also suggests that elderly people maintain the ability to acquire new information and strategies. The aim of the present study was to inv...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(03)00063-3
更新日期：2003-11-01 00:00:00
abstract：:A study of the intracellular distribution of prion protein (PrP) in N2a neuroblastoma cells which had been infected with prions (ScN2a cells) revealed that most PrP is present in the cytoplasm. However, a significant amount of PrP is also present in the nucleus (predominantly in the nucleoli) of these cells, as analyz...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(96)00770-4
更新日期：1997-07-01 00:00:00
abstract：:Digitalis glycosides have played an important role in the treatment of patients with heart failure (HF) for more than two centuries. Despite the introduction of new therapeutic strategies in the treatment of HF, and controversies regarding the role of digitalis in HF in sinus rhythm and its effect on mortality, digoxi...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(96)00729-7
更新日期：1996-11-01 00:00:00
abstract：:Nutritional status and functional ability are mutually dependent especially in the elderly. This study examined the functional status-predictive ability of the MNA in a cross-sectional study. We analyzed the dataset of the "Survey of Health and Living Status of the Elderly in Taiwan" (SHLSET). Subjects were 2948≥65 ye...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.12.006
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:This study investigated the factors associated with depressive symptoms among community-dwelling Filipino senior citizens. METHODS:We conducted a cross-sectional study among 1021 Filipino senior citizens aged 60-91 years. We used multiple linear regression analysis to identify the factors independently assoc...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2019.02.014
更新日期：2019-01-01 00:00:00
abstract：:To evaluate the capacity to perceive bitter taste in a sample of the elderly population of the Brazilian Federal District, and to investigate its association with the consumption profile of distinct food groups. A total of 255 female outpatients aged 60 years or older took part in this cross-sectional study. The follo...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.05.019
更新日期：2012-03-01 00:00:00
abstract：:This study evaluated various outcomes of home care in a group of 121 chronically ill and frail elderly subjects followed for 24 months, starting from September 2001. The scheduled times of follow up were baseline, 6, 12, and 24 months. Subjects of both sexes were assigned to one of two groups. Control group (CG) (60 s...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2006.03.002
更新日期：2007-03-01 00:00:00
