Correlations between C-reactive protein, interleukin-6, tumor necrosis factor-alpha and body mass index during senile osteoporosis.

Abstract:

:Serum concentrations of C-reactive protein (CRP), interleukin-6 (Il-6) and tumor necrosis factor-alpha (TNF-alpha), as well as body mass index (BMI) were measured in a series of 36 elderly subjects (18 males, 18 females) of mean age 76.8+/-4.5 years, in order to assess whether these parameters are involved in senile osteoporosis (SOP). Bone mineral density was determined, by a dual-emission X-ray absorbimetry (dexa) method on the nondominant radius, as a measure of SOP. These studies revealed the following main results: (i) the female/male ratio of SOP at this age is 4:1; (ii) overweight has a sort of protection against SOP in females; (iii) increased Il-6 and TNF-alpha serum levels when observed in either of the sexes were accompanied by SOP, indicating that these parameters may be involved in provoking and maintaining SOP; (iv) elevated serum CRP levels indicate, in most elderly subjects, the presence of inflammation in SOP which has been considered previously as a merely 'wear and tear'-induced disease.

journal_name

Arch Gerontol Geriatr

authors

Maugeri D,Russo MS,Franzé C,Motta V,Motta M,Destro G,Speciale S,Santangelo A,Panebianco P,Malaguarnera M

doi

10.1016/s0167-4943(98)00110-1

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

159-63

issue

2

eissn

0167-4943

issn

1872-6976

pii

S0167-4943(98)00110-1

journal_volume

27

pub_type

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