Abstract:
:Age-related changes of the hippocampal mossy fibre system were studied in rats of different ages (4, 12, and 24 months) using the Timm's histochemical technique for the detection of tissue stores of zinc and heavy transitional metals. Quantitative image analysis and microdensitometry techniques were applied for the evaluation of the changes themselves. The area occupied by mossy fibres and the intensity of Timm's staining in field CA3 of hippocampus were greater in adult rats than in young and old animals. These findings are consistent with previous behavioural data indicating that young and old rats exhibited a reduced passive avoidance learning with respect to adult animals. The above techniques were also used in a second session of this study designed to investigate the effect of a 6-months treatment with acetyl-L-carnitine (ALC) on the hippocampal mossy fibre system. ALC was found to increase significantly the area occupied by mossy fibres and the intensity of Timm's staining in the hippocampus of old rats. These findings are in agreement with and support from an anatomical point of view, the data indicating that long-term treatment with ALC improves passive avoidance performance.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Ricci A,Ramacci MT,Ghirardi O,Amenta Fdoi
10.1016/0167-4943(89)90071-xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
63-71issue
1eissn
0167-4943issn
1872-6976pii
0167-4943(89)90071-Xjournal_volume
8pub_type
杂志文章abstract::There has been an extraordinary reversal in the perceived merits of sheltered housing. Once held up as the unquestioned solution to the housing needs of elderly people, it has now fallen under a cloud which has been referred to as a 'crisis of confidence'. This paper reassesses the contribution of research to the deba...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(91)90003-9
更新日期:1991-01-01 00:00:00
abstract::Aging seems to be related to various vascular diseases, such as dissecting aneurysm and atherosclerosis. The nature of the relationship between aging and these vascular diseases has not been completely clarified. The goal of this study was to investigate, using morphological and morphometrical methods, the age related...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(93)90016-b
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abstract::Nutritional status and functional ability are mutually dependent especially in the elderly. This study examined the functional status-predictive ability of the MNA in a cross-sectional study. We analyzed the dataset of the "Survey of Health and Living Status of the Elderly in Taiwan" (SHLSET). Subjects were 2948≥65 ye...
journal_title:Archives of gerontology and geriatrics
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journal_title:Archives of gerontology and geriatrics
pub_type: 临床试验,杂志文章
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abstract::Low serum albumin level is associated with poor functional outcome and predicting a greater functional decline in the elderly. The aim of this study is to determine the interrelation between change of serum albumin level during rehabilitation period and functional outcome in hip fracture patients. We studied 433 conse...
journal_title:Archives of gerontology and geriatrics
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journal_title:Archives of gerontology and geriatrics
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journal_title:Archives of gerontology and geriatrics
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abstract::Twenty-three institutionalized subjects, confused and disoriented as to time, space and persons, were divided into two groups: the study group and the control group. The study group then participated in a 3-month period of formal Realithy Orientation Therapy (ROT). At the end of the 3 months of therapy significant dif...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
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journal_title:Archives of gerontology and geriatrics
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journal_title:Archives of gerontology and geriatrics
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journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(05)80065-2
更新日期:1994-01-01 00:00:00
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journal_title:Archives of gerontology and geriatrics
pub_type: 临床试验,杂志文章
doi:10.1016/0167-4943(92)90007-q
更新日期:1992-01-01 00:00:00
abstract::The BMS is a common chronic pain condition which mainly affects old women. The high prevalence of oral parafunctional habits and dry mouth symptoms in patients with BMS suggests that inflammation at the subclinical level due to repetitive microtrauma may cause burning mouth sensations. In this study, using a comprehen...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2009.08.008
更新日期:2010-07-01 00:00:00
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journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2004.08.001
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journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,meta分析
doi:10.1016/j.archger.2019.103941
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The prevalence of CKD rises with age. The prevalence of CKD-related metabolic complications in the oldest old in relation to different GFR estimations is largely unknown. eGFR-based thresholds for the detection of these complications remain uncertain. METHODS:A cross-sectional analysis embedded within the B...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2011.12.010
更新日期:2012-05-01 00:00:00
abstract::The cytotoxic activity of natural killer (NK) cells under both basal and interferon (IFN)-induced conditions, as well as the proliferative response of lymphocytes to ConA in old rats treated in vivo with AL-721 have been analyzed. The low levels of basal NK cell activity present in spleen of old rats were completely r...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(05)80030-5
更新日期:1992-01-01 00:00:00
abstract::Statistical data of Italy, issued on 1st January 2005, show that Tuscany has a high percentage of elderly subjects, and that to reach 100 years is a common possibility, mainly for women. Comparable values appear for longevity index (LI%), either calculated on the basis of the various resorts above sea level, or on the...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2008.02.002
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journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
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journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,随机对照试验
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journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2014.12.003
更新日期:2015-03-01 00:00:00
abstract::The risk for all the manifestations of atherosclerotic disease is increased in patients affected by type 2 diabetes mellitus. The aim of the present work was to evaluate the prevalence of coronary heart disease (CHD) in a well-characterized middle-aged and elderly Italian diabetic population. The population studied in...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(99)00031-x
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Hemodialysis patients in Japan are aging, but the influence of lifestyle factors on EuroQoL 5-Dimension 5-Level (EQ-5D-5 L) scores in older hemodialysis patients is unclear. This study aimed to measure health-related quality of life using the EQ-5D-5 L for older hemodialysis patients and to identify the life...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Delirium, a serious condition observed in critically ill patients, clinically presents with impaired cognition and consciousness. The relationship between delirium and peripheral levels of insulin growth factor-1 (IGF-1) is unclear. Thus we conducted a meta-analysis to address this issue. METHODS:Seven ma...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,meta分析
doi:10.1016/j.archger.2018.03.011
更新日期:2018-01-01 00:00:00
abstract::Although an association between SA concentrations and mortality in the patients is well known, this association is not conclusive in elderly community-dwelling populations. We therefore attempted to determine whether this association could be extended to a Japanese 70-year-old community-dwelling population. Seventy-ye...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2011.02.018
更新日期:2012-01-01 00:00:00
abstract::Our aim was to compare the prevalence of sarcopenia in men and women with hip fracture. We studied 591 of 630 hip fracture inpatients consecutively admitted to our Rehabilitation ward. All the patients underwent a Dual-Energy X-Ray Absorptiometry (DXA) scan 18.4 ± 8.7 (mean ± SD) days after hip fracture occurrence. Sa...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2012.05.002
更新日期:2012-09-01 00:00:00
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journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(94)00578-u
更新日期:1995-03-01 00:00:00
abstract::The purpose of this study was to evaluate the validity and reproducibility of the modified lateral functional reach (FR), and to examine the associations between a variety of functional variables and the FR in community-dwelling older people (>65 years of age). A total of 383 aged Japanese participated in this study a...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2005.06.010
更新日期:2006-03-01 00:00:00
abstract::This random double-blind trial compares psychological well-being and perceived quality of life in 60 subjects (18 M, 42 F), mean age 61 years, with age-associated memory impairment (AAMI), who were administered a standardised ginseng-containing vitamin complex or placebo for 9 months. We evaluated psychological well-b...
journal_title:Archives of gerontology and geriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-4943(95)00659-9
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVES:This study explored the associations of empty nest and group activity with cognitive impairment in Chinese older adults. MATERIALS AND METHODS:Data were analyzed from 10,349 participants of the second-round survey database of the Zhejiang Ageing and Health Cohort Study aged 60 years and over. Cognitive impa...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2020.104120
更新日期:2020-01-01 00:00:00