Abstract:
:The osteoporosis is a systemic disease of multicausal etiopathogenesis. A progressive bone loss and qualitative alterations in the macro- and micro-architecture of the remaining bones, resulting in a loss of strength of bones to such an extent that even very modest traumas will cause fractures characterize it. Three forms are defined (i) postmenopausal appearing after the menopause, (ii) senile appearing with advancing age, and (iii) the idiopathic forms. Severe osteoporosis is declared when the patients suffer vertebral or femoral fractures without any trauma during a treatment with anti-reabsorptive medicines of at least 1-year. The treatment of osteoporosis is based on various categories of pharmaca, such as bisphosphonates, selective estrogen receptor modulators (SERMs), diaminobutyric acid (DABA), parathyroid hormone (PTH), estrogens and non-hormonal drugs. The teriparatide, the recombinant human (rh)PTH(1-34), is identical in amino acid sequence until the 34th (N-terminal) amino acid of the endogenous, human PTH. It is produced in E. coli using the recombinant DNA technology. It is a pharmacon having a strong trophic-anabolic action on the bone tissue, assuring both the inhibition of the bone loss, and the formation of new bones of good quality. It acts as a stimulant of the osteoblast functions, and at the same time, increases the absorption of calcium from the intestine, and also the renal reabsorption of calcium, and decreases the excretion of phosphates in the kidney. This study summarizes our own experience with the use of rhPTH(1-34) in the treatment of senile patients with severe osteoporosis. Our sample consisted of 40 elderly women of the mean age of 78+/-5 years, having severe osteoporosis. They displayed a columnar T-score>-3.5 and femoral T-score>-2.5, had been under antireabsorptive treatment since at least 12 months. In particular, 15 patients were treated with Alendronate (70 mg/week), 10 of them with Risedronate (35 mg/week), and 15 of them with Raloxifene (60 mg/day). These patients in our study were treated for 1 year with 20 microg/day of rhPTH (1-34), injected subcutaneously, and supplemented also with a daily dose of 1g of calcium and 800 IU of Vitamin D, per os. At start of this treatment (time t(0)), after 6 months (time t(6)) and after 12 months (time t(12)) patients underwent a bone mineral density (BMD) analysis (Dexa-Lunar-DPX-P) on the lumbar vertebral column, (L1-L4 zone), as well as a femoral BMD. We applied also quality of life (QoL) questionnaire of the European Foundation for Osteoporosis (QUALEFFO), and evaluated also the use of non-steroidal anti-inflammatory drugs (NSAIDs). Our final considerations are that the teriparatide therapy increases significantly the bone mass density, expressed in terms of T-Score, reduces the occurrence of new fractures, improves the QoL, and decreases also the consumption of NSAIDs.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Manuele S,Sorbello L,Puglisi N,Grasso S,La Malfa L,D'Urbino G,Rizzotto M,Strano S,Maugeri Ddoi
10.1016/j.archger.2007.01.034subject
Has Abstractpub_date
2007-01-01 00:00:00pages
249-58eissn
0167-4943issn
1872-6976pii
S0167-4943(07)00035-0journal_volume
44 Suppl 1pub_type
杂志文章abstract::There are still conflicting results regarding the association between grip and global muscle strength in older people. Therefore, the objective of the present study was to determine the association between grip strength and global muscle strength, as well as between grip strength and individual trunk, hip, knee and an...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2019.03.005
更新日期:2019-01-01 00:00:00
abstract:AIM:This study aimed to compare the effects of two exercise programs on balance and risk of falls in older women with age-related visual dysfunction. METHODS:Participants living in a residential home were randomly allocated to Group I (n=21) receiving a progressive, tailored multimodal exercise program in addition to ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.archger.2012.01.009
更新日期:2012-09-01 00:00:00
abstract::We have described twelve dementia patients with noise making. We categorized noise making into (i) persistent screaming, (ii) perseverative vocalization, (iii) continuous chattering, muttering, singing or humming, and (iv) swearing, grunting and bizarre noise-making. The patients' ages ranged from 70 to 92 years with ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(02)00169-3
更新日期:2003-05-01 00:00:00
abstract::In Asian families, where patriarchal family systems are common, living arrangements of older adults are characterized by residing with a married son. This study examines the synergic effects of intergenerational solidarity (emotional and instrumental support exchange and anticipated support) on depression of older adu...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2010.06.007
更新日期:2011-07-01 00:00:00
abstract::The management of advanced cancer in the older person is variable. In some patients with common malignancies chemotherapy may palliate symptoms and prolong survival, while in other patients chemotherapy is a cause of overwhelming toxicity and supportive care is the preferred form of treatment. We explored the principl...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(90)90015-x
更新日期:1990-03-01 00:00:00
abstract::Influenza virus infection is a major respiratory infectious disease that generally induces pneumonia. The clinical manifestations of influenza virus infection and community-acquired pneumonia (CAP) differ between elderly persons and younger adults. To determine the clinical features of influenza-associated pneumonia, ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1016/j.archger.2008.11.015
更新日期:2009-09-01 00:00:00
abstract:UNLABELLED:Knee pain is a common health problem in the elderly population, for which non-invasive treatments are recommended as a first line treatment in the management of knee pain. A randomized controlled trial was conducted to determine the effects of exercise with or without thermal therapy in community-dwelling el...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.archger.2013.06.008
更新日期:2013-11-01 00:00:00
abstract::The aim of this survey was to estimate the burden of antimicrobial use and to describe the determinants for antimicrobial use in Hungarian long-term care facilities (LTCFs) in order to increase the attention given to the proper prescription for this vulnerable population. A one-day point-prevalence study was undertake...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2014.02.011
更新日期:2014-07-01 00:00:00
abstract::The purpose of the study was to determine oral health status and the prevalence of oral mucosal lesions among hospitalized elderly patients with physical disabilities. The study group consisted of 111 (43 male and 68 female) elderly patients with physical disabilities. Clinical examination and interview methods were e...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2004.11.005
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:The aim was to classify motives for exercising trying to find sets of related cases that share common motivations, and to relate these latent classes to markers of successful aging. METHODS:725 old adult aged 55 to 97 years were sampled in several Spanish towns. INSTRUMENTS:Successful Aging Inventory (SAI), I...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2018.04.003
更新日期:2018-01-01 00:00:00
abstract::Specific conditions associated with surgery may predispose elderly people to septic complications after hip fracture surgery. This study investigated the risk factors predisposing infection in aged patients with subcapital hip fracture. We performed a prospective study of 290 patients with displaced subcapital hip fra...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2009.01.009
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study was to investigate how bladder management, rather than urinary incontinence, may affect the functional outcome of ischemic stroke patients. We studied 919 consecutive patients admitted for ischemic stroke rehabilitation. Level of bladder management was determined by Functional Independence Me...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2010.07.007
更新日期:2011-09-01 00:00:00
abstract::The aims were to evaluate the cognitive performance and clinical diagnosis in patients (<75 years) seeking help for subjective memory complaints, to determine the prevalence of certain psychiatric symptoms and to conduct follow-up examinations. At baseline 41% showed normal cognitive performance (subjective memory imp...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2010.02.009
更新日期:2010-11-01 00:00:00
abstract::Using stress process theory and structural equation modelling, this study investigated the complex relationship between health status, family strain, dependency, and the life satisfaction of rural older adults with reported functional impairments in India. Data were extracted from a large-scale study of 903 randomly s...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2017.04.001
更新日期:2017-07-01 00:00:00
abstract::We investigated the occurence and causes of anaemia and other haematological abnormalities in 142 elderly patients (43 men, 99 women; median age 79 and 80 years), admitted to long-term care. Healthy 81-year-old subjects (n = 220) were used as reference group. Anaemia according to the WHO definition was much more commo...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(92)90026-z
更新日期:1992-05-01 00:00:00
abstract::The purpose of this study was to evaluate the effect of structured group reminiscence therapy on behavior competence and physical functioning and to compare effectiveness of the intervention by stage of dementia in Taiwanese elders residing in institutional settings. A longitudinal experimental design was used. Sevent...
journal_title:Archives of gerontology and geriatrics
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.archger.2008.08.007
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Investigate the effects of complementary therapies on functional capacity and quality of life among prefrail and frail older adults. MATERIALS AND METHOD:An electronic search was performed in the PubMed, EMBASE, Web of Science, Cochrane Library, LILACS and PEDro databases for relevant articles published up t...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,评审
doi:10.1016/j.archger.2020.104236
更新日期:2020-08-21 00:00:00
abstract:OBJECTIVE:To design and validate a predictive BIA equation to estimate ASM in a sample of non-Caucasian older people and to explore the accuracy of two previous single-frequency BIA published equations. METHOD:This is a cross-sectional study in 213 physically-independent and apparently healthy older men and women subj...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2015.03.007
更新日期:2015-07-01 00:00:00
abstract::Based on the motivational sequence described in Self-Determination Theory, this study explored the relationship between relatedness, motivation, adaptation and leisure in nursing homes. We formulated the hypothesis that the variables of the study would be found in an integrative mediational sequence: Participation in ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2016.12.004
更新日期:2017-01-01 00:00:00
abstract::This study was performed in 52 women, aged 60 to 76 years: 27 were engaged in a gymnastics program, 3 h a week, for at least 2 years; 25 were age-matched controls. All were lifelong nonsmokers, free of disease symptoms and lived independently at home; none had previously engaged in exercise programs. Spirometry includ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(95)00686-9
更新日期:1996-03-01 00:00:00
abstract::There is evidence of an association of hypertension with white matter lesions (WMLs), leukoaraiosis, in the human brain in the United States, Europe and Japan. However, no study on this association has been reported in Korea. Community-dwelling elderly subjects aged over 61 years were randomly selected from samples of...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2004.09.003
更新日期:2005-05-01 00:00:00
abstract::The calcium (Ca) antagonist flunarizine hydrochloride (FNZ) has been reported to induce parkinsonism, especially in the elderly. The effects of FNZ on dopamine receptors in rat striatal membranes, especially in aged rats, were studied using radiolabeled receptor assay. Similar displacing potencies in [(3)H]spiperone b...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(91)90049-v
更新日期:1991-11-01 00:00:00
abstract::In a study of ten young and seven elderly healthy men we have performed an oral glucose tolerance test (75 g) and employed a euglycemic hyperinsulinemic (0.25 mUx kg/min) glucose clamp technique in order to determine insulin sensitivity. This latter experimental protocol consisted of 120 min of euglycemic clamp follow...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(90)90026-3
更新日期:1990-05-01 00:00:00
abstract::In a single-blind, placebo-controlled study the acute and chronic antianginal effects of three slow-release (SR) new formulations of isosorbide dinitrate (ISDN 60, 80, 100 mg) have been comparatively evaluated in a group of aged affected by chronic stable effort-induced angina. Compared to placebo, overall the active ...
journal_title:Archives of gerontology and geriatrics
pub_type: 临床试验,杂志文章
doi:10.1016/0167-4943(92)90007-q
更新日期:1992-01-01 00:00:00
abstract::We studied the change in personal ability to perform the activities of daily living (P-ADL) one year after hospitalization (T2) of patients at least 65 years old at baseline (T1). The study included 363 (175 men) medical inpatients with age range 65-98 (mean 80.2, SD 7.5) years. Information was collected at baseline a...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2013.05.008
更新日期:2013-11-01 00:00:00
abstract::The BMS is a common chronic pain condition which mainly affects old women. The high prevalence of oral parafunctional habits and dry mouth symptoms in patients with BMS suggests that inflammation at the subclinical level due to repetitive microtrauma may cause burning mouth sensations. In this study, using a comprehen...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2009.08.008
更新日期:2010-07-01 00:00:00
abstract::The concept of selective survival to advanced ages is introduced and discussed in relation to the black/white mortality "crossover" in the United States. Crossover refers to the phenomenon wherein black mortality rates become lower than white mortality rates after approximately age 75. This reversal of mortality rates...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,评审
doi:10.1016/0167-4943(84)90022-0
更新日期:1984-10-01 00:00:00
abstract::Chronic musculoskeletal pain is a common, disabling condition that affects at least one in four elderly people. Figures are much higher in nursing homes, in which as many as 45-80% of residents has pain that contributes to functional impairment and decreased quality of life. Multiple comorbidity, under-reporting of sy...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2007.01.024
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To investigate the interrelationships between central obesity, sarcopenia and nutritional status in the elderly. METHODS:We enrolled 501 elderly (women: 47.5 %) with complete datasets. Biochemical and anthropometric data were measured after an overnight fast. Basic characteristics, psychosocial and behavior...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2019.104003
更新日期:2020-01-01 00:00:00
abstract::Medical utilization by elderly population is influenced by a number of factors, and physical disabilities may play an important role. Despite the fact that extensive studies have been carried evaluating medical utilization by older individuals, little is known regarding the impact of physical disabilities on eye care ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2011.10.020
更新日期:2012-03-01 00:00:00