当前位置： SCI文献检索 > ARCHIVES OF GERONTOLOGY AND GERIATRICS期刊下所有文献 > Comparative evaluation of three dosages of slow-release isosorbide dinitrate (60, 80, 100 mg) in chronic angina of the aged.

Comparative evaluation of three dosages of slow-release isosorbide dinitrate (60, 80, 100 mg) in chronic angina of the aged.

Abstract：

:In a single-blind, placebo-controlled study the acute and chronic antianginal effects of three slow-release (SR) new formulations of isosorbide dinitrate (ISDN 60, 80, 100 mg) have been comparatively evaluated in a group of aged affected by chronic stable effort-induced angina. Compared to placebo, overall the active dose paritetically improved the effort tolerance up to 24 h after the first assumption. In the time course of the trial (2 and 4 weeks) the resting hemodynamic changes induced by the first dose were partially blunted without affecting the exercise related-parameters. Also if plasma levels of ISDN and of its metabolites did not correlate to the degree of physical improvement, the peak increase in effort tolerance was observed under 100 mg treatment. Mild to moderate transient headache was experienced by 50% of actively treated and by 20% of placebo treated patients and no other serious adverse effects have been noted. One may conclude that ISDN in slow-release formulations of 60-100 mg isan effective, safe and well tolerated medication in the management of angina in the aged.

journal_name

Arch Gerontol Geriatr

journal_title

Archives of gerontology and geriatrics

authors

Mazzola C,Vaccarella A,Serra G,Lissoni F,Piemonti C,Fasana S,Poggi-Longostrevi G,Renzetti I,Maggi GC

doi

10.1016/0167-4943(92)90007-q

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

65-73

issue

1

eissn

0167-4943

issn

1872-6976

pii

0167-4943(92)90007-Q

journal_volume

14

pub_type

临床试验,杂志文章

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