Abstract：
:The calcium (Ca) antagonist flunarizine hydrochloride (FNZ) has been reported to induce parkinsonism, especially in the elderly. The effects of FNZ on dopamine receptors in rat striatal membranes, especially in aged rats, were studied using radiolabeled receptor assay. Similar displacing potencies in [(3)H]spiperone bindings were exhibited for FNZ and the Ca antagonists verapamil and nicardipine. FNZ was found to directly and competitively effect D2 receptors (D2-Rs) as an antagonist, without effecting D1 receptors. Furthermore, the washing of preoccupied membranes revealed that FNZ has a long-acting potent effect on D2-Rs. The comparative study of FNZ and sulpiride in young-adult and aged rats showed that the effect of FNZ on D2-Rs was more marked in aged rats. These results might be related to FNZ-induced parkinsonism and its high incidence in the elderly.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Asanuma M,Ogawa N,Haba K,Hirata H,Mori Adoi
10.1016/0167-4943(91)90049-vsubject
Has Abstractpub_date
1991-11-01 00:00:00pages
271-8issue
3eissn
0167-4943issn
1872-6976pii
016749439190049Vjournal_volume
13pub_type
杂志文章abstract：:In a super-aged society, the need for prevention of locomotor dysfunction is growing, and evidence for feasible preventive measures is thus required. This study aimed to examine the relationship between these disorders and the prevalence rates for falling and physical function status. Participants included 1182 commun...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.05.005
更新日期：2013-11-01 00:00:00
abstract：:Two hundred and fifty-six carers of elderly people aged 70 and over were questioned on their attitudes towards their caring role and their preferences for their own future care. Despite the fact that most were providing assistance at high personal cost, most cares were highly committed to their caring role. However, t...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(92)90050-e
更新日期：1992-03-01 00:00:00
abstract：:This study was aimed to determine the pain, physical performance and balance conditions of the elderly hospitalized in university hospital geriatric wards. The reasons for hospitalization and co-morbid diseases were recorded. Severity of pain was assessed on a visual analogue scale. Activity independence ability was t...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.08.002
更新日期：2011-05-01 00:00:00
abstract：:The association between adverse health and loneliness among aging people is known, but most of the studies are cross-sectional. In addition, the associations between changes in loneliness with health are less well known, especially in the case of aging people. The present study examined whether absence of loneliness i...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.023
更新日期：2011-09-01 00:00:00
abstract：:The central question in the field of experimental gerontology is: what is biological aging? It is true that a living body must obey the laws of causal determinism; like all bodies it is subject to the physical and chemical laws of the phenomenal world. But there is a further aspect; as well as the finality which unite...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/0167-4943(88)90005-2
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:Research indicates that self-care affects lifestyle and health behaviors; however, little is known about whether or not self-care affects medical utilization. OBJECTIVES:Exploring the effects on self-care behaviors to medical utilizations by elderly with chronic conditions. METHOD:Data from the Taiwanese N...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.01.014
更新日期：2015-05-01 00:00:00
abstract：:A modified version of the GDS was created to manage the difficulties often encountered with very old respondents. The scale was applied to 195 old persons (mean age of 78 years), males and females, community-dwelling, and nursing home residents. Results indicate that the participants comprehend significantly better th...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2006.04.002
更新日期：2007-03-01 00:00:00
abstract：:Due to the difficulties in recruiting elderly people for psychological studies, a wide range of recruitment methods has been used. The underlying assumption that the recruitment method does not seriously affect the results has to be tested. Results in different worry measures are compared between three samples which w...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.archger.2007.09.009
更新日期：2009-01-01 00:00:00
abstract：:We studied the relation between cholesteryl-ester transfer activity (CETA) and abdominal aortic calcification in elderly subjects. Compared with 10 young healthy subjects (mean +/- S.D. age, 27 +/-2 years) and to 26 elderly subjects without abdominal aortic calcification (79 +/- 7 years), 16 elderly patients with abdo...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(93)90022-a
更新日期：1993-01-01 00:00:00
abstract：:Intermittent (every-other-day) feeding initiated at 19 months of age and continued for 12 weeks, led to a moderate decrease in body weight of aging rats, enhanced survival and modified diurnal changes in body temperature and fever response to bacterial endotoxin (E. coli lipopolysaccharide, LPS). Diet-restricted anima...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(96)00746-7
更新日期：1997-03-01 00:00:00
abstract：:Aim of the study was to investigate the replicability and reliability of the multi-dimensional health assessment questionnaire (MDHAQ) and visual analog scale (VAS) in young and elderly individuals with chronic pain. Ambulatory patients, 20 of them aged above 65 years and complaining about chronic pain and 20 patients...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.017
更新日期：2011-07-01 00:00:00
abstract：:The management of advanced cancer in the older person is variable. In some patients with common malignancies chemotherapy may palliate symptoms and prolong survival, while in other patients chemotherapy is a cause of overwhelming toxicity and supportive care is the preferred form of treatment. We explored the principl...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(90)90015-x
更新日期：1990-03-01 00:00:00
abstract：:We aimed to examine the validity of fall risk assessment items for the healthy community-dwelling elderly Japanese population. Participants were 1122 healthy elderly individuals aged 60 years and over (380 males and 742 females). The percentage who had experienced a fall was 15.8%. This study used fall experience and ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.010
更新日期：2011-07-01 00:00:00
abstract：:The encouraging results of recent multicenter clinical trials conducted in the US on the effect of carvedilol therapy in patients with chronic heart failure, prompted us to verify its tolerability in a group of elderly patients. For the open, randomized, placebo-controlled study, we selected 40 patients (28 men and 12...
journal_title：Archives of gerontology and geriatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0167-4943(99)00040-0
更新日期：1999-11-01 00:00:00
abstract：:We studied the factors influencing the choice of admission to Geriatrics units, instead of other acute hospital units after an emergency visit. We report the results from a cohort of 1283 randomly selected patients aged >75 years hospitalized in emergency and representative of the French University hospital system. Al...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.01.018
更新日期：2011-01-01 00:00:00
abstract：:Nutritional status is important to elders to live without disabilities. Food Insecurity (FI) is a risk factor associated with poorer nutritional status among elderly as well as a social determinant. This research aimed to identify FI prevalence and to explore the relation between FI, weight status and socio-demographi...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2018.06.004
更新日期：2018-01-01 00:00:00
abstract：:We reported previously that the pancreatic protein responses to the high dose of cholecystokinin (CCK) or bile-pancreatic juice diversion were impaired in old rats of both sexes, whereas the basal secretion was comparable to that in young animals. To examine the mechanism of the attenuated response in old rats, we exa...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(98)00006-5
更新日期：1998-05-01 00:00:00
abstract：:A double blind, comparative, parallel and randomized clinical trial was used for evaluation of two nootropics with anti-aging actions: Meclofenoxate (MF) and Antagonic-Stress (AS). Sixty-three old persons divided into 2 groups (average age: 68.6 and 70.8 years, respectively) with senile dementia of Alzheimer type (SDA...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(05)80065-2
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVES:To understand whether disability trajectories mediated the association between sociodemographic characteristics and later health care and long-term care services use. METHODS:Data were from the Taiwan Longitudinal Study on Aging Survey, 1996-2007 (N =3429). Latent class growth curves modeling and structural...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2019.01.019
更新日期：2019-01-01 00:00:00
abstract：:This study investigates the implications of different levels of cognitive decline on functional status in frail older adults. Four cognitive trajectories, including two with catastrophic cognitive decline, were defined in a 3-year study. Participants with complete cognitive and functional status data at baseline, 12 a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2007.09.007
更新日期：2009-01-01 00:00:00
abstract：INTRODUCTION:Sarcopenia is a geriatric syndrome related to loss of muscle mass and function, leading to disability, frailty and higher mortality. According to European Working Group on Sarcopenia in Older People (EWGSOP) the diagnosis of sarcopenia requires the assessment of muscle mass, muscle force and function, that...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2019.03.021
更新日期：2019-01-01 00:00:00
abstract：:SPH is a subjective and objective assessment of personal health. It is important in evaluation of health status in the elderly as it has capacity to predict mortality, functional declining, and health-care demands. A lot of research has been published about SPH in the elderly, but little is known about SPH in the very...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2009.09.036
更新日期：2009-01-01 00:00:00
abstract：:Numerous studies have affirmed the existence of a correlation between various cardiovascular diseases and functional decline in elderly people. Not much information, however, is available concerning the overall effect of various, possibly coexisting, cardiovascular pathologies, or metabolic conditions notoriously rela...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(00)00085-6
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVES:The objectives were to determine the prevalence of atypical presentations among older adults at the Emergency Department (ED) of a tertiary care hospital and to identify factors associated with these presentations. MATERIAL AND METHODS:A retrospective medical record audit was randomly reviewed in 633 patien...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.08.016
更新日期：2016-01-01 00:00:00
abstract：:Nowadays because of lots of reasons, lifespan is increasing and caregiving of aged people becomes more and more important. Today it is understood how the professional care of aged people is significant, instead of being carried out by volunteers. Because of this, in this study we aimed to understand the problems, and ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.08.002
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Bisphosphonate therapy may have actions beyond bone, including effects on cardiovascular, immune and muscle function. We tested whether bisphosphonate treatment is associated with improved outcomes in older people undergoing inpatient rehabilitation. METHODS:Analysis of prospectively collected, linked routi...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2017.01.017
更新日期：2017-01-01 00:00:00
abstract：:Digitalis glycosides have played an important role in the treatment of patients with heart failure (HF) for more than two centuries. Despite the introduction of new therapeutic strategies in the treatment of HF, and controversies regarding the role of digitalis in HF in sinus rhythm and its effect on mortality, digoxi...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(96)00729-7
更新日期：1996-11-01 00:00:00
abstract：:To compare the clinical outcomes and length of stay (LOS) between delirious patients with hyperactive symptoms admitted directly and those admitted indirectly from Emergency Department into a secured, behavioral unit jointly used by geriatricians and pyschogeriatricians (the Unit). A retrospective study analyzing data...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.02.001
更新日期：2011-01-01 00:00:00
abstract：:The study of the age and passage dependent modifications of collagen biosynthesis requires a simple, rapid and reproducible procedure adaptable to serial cell cultures. To make such a method comparable to other methods of collagen determination, we calibrated a colorimetric procedure both by hydroxyproline (HYP) deter...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2007.08.019
更新日期：2008-11-01 00:00:00
abstract：:The study was to compare the ability of BMI, MAC and CC in predicting nutritional status, functional ability and follow-up mortality risk of older adults. The study purposively recruited 160 of 320 residents of a nursing home in Central Taiwan to serve as subjects. Residents who were ≥65 years old, cognitively normal,...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.05.015
更新日期：2012-05-01 00:00:00
