Abstract：
:There is evidence of an association of hypertension with white matter lesions (WMLs), leukoaraiosis, in the human brain in the United States, Europe and Japan. However, no study on this association has been reported in Korea. Community-dwelling elderly subjects aged over 61 years were randomly selected from samples of the Ansan Health Study, while their blood pressures (BPs) were measured using a highly standardized protocol. Hypertension was defined as a systolic BP> or =140 mmHg or a diastolic BP> or =90 mmHg or as reported treatment with hypertensive medication, and further subclassified with respect to its subtypes and control status. WMLs were determined by a 1.5-T MRI scan and further categorized into five subgroups with respect to its severity. Hypertension status, such as uncontrolled hypertension even after antihypertensive medication (adjusted odd ratio [OR]=6.07; 95% CI, 2.08-17.78), isolated systolic hypertension before medication (OR=2.66; 95% CI, 1.08-6.57), and hypertension before medication (OR=2.55; 95% CI, 1.19-5.46) were significantly and independently correlated with the presence and severity of WMLs. Advancing age (OR=1.76; 95% CI, 1.38-2.25), lacunar infarction (OR=3.19; 95% CI, 1.83-5.58), and cigarette smoking (OR=1.10; 95% CI, 1.03-1.18) were significantly related to the presence and severity of WMLs. Regular and tight control for hypertension should be exercised to prevent WMLs among the elderly with hypertension.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Park MK,Jo I,Park MH,Kim TK,Jo SA,Shin Cdoi
10.1016/j.archger.2004.09.003subject
Has Abstractpub_date
2005-05-01 00:00:00pages
265-73issue
3eissn
0167-4943issn
1872-6976pii
S0167-4943(04)00168-2journal_volume
40pub_type
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