Abstract：
INTRODUCTION:The neuroprotective effect of valproic acid has been observed in the animal models of neurodegeneration, which suggests it as a potential candidate for clinical trials. In this paper, we aimed to systematically analyze the efficacy and safety of valproic acid in the treatment of dementia. METHODS:We searched the electronic databases PubMed, EMBASE, CINAHL, Cochrane Library and China National Knowledge Infrastructure until March 2020 for the eligible randomized controlled trials, as well as the unpublished and ongoing trials. We pooled the results using a random-effects model. RESULTS:We included seven studies with 770 randomized patients with dementia, which compared valproic acid with placebo. Indeed, there were no significant differences found in the scores of Mini-mental State Examination, Cohen-Mansfield Agitation Inventory and number of patients with adverse events. Valproic acid is generally well-tolerated in patients with dementia, even in long-term therapy for 24 months. CONCLUSION:Insufficient evidences are found to support valproic acid in the treatment of dementia for cognitive, psychiatric symptoms or disease-modifying. The anticipations for a success in the trial of valproic acid for dementia in the future look not optimistic based on the available evidence.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Liu J,Wang LNdoi
10.1016/j.archger.2020.104091subject
Has Abstractpub_date
2020-01-01 00:00:00pages
104091eissn
0167-4943issn
1872-6976pii
S0167-4943(20)30085-6journal_volume
89pub_type
杂志文章,meta分析abstract：:Sleep is an active nervous process, which is structured in phases characterized by subsequent cycles of various psycho-physiological phenomena. It performs vital, yet mysterious functions and is in all likelihood involved in many processes, including cognitive processes. In old age the internal structure of sleep chan...
journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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doi：10.1016/0167-4943(93)90052-j
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(86)90015-4
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(98)00131-9
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(05)80020-2
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2004.09.003
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
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doi：10.1016/j.archger.2018.12.014
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(97)00016-2
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(91)90049-v
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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