Abstract:
INTRODUCTION:The neuroprotective effect of valproic acid has been observed in the animal models of neurodegeneration, which suggests it as a potential candidate for clinical trials. In this paper, we aimed to systematically analyze the efficacy and safety of valproic acid in the treatment of dementia. METHODS:We searched the electronic databases PubMed, EMBASE, CINAHL, Cochrane Library and China National Knowledge Infrastructure until March 2020 for the eligible randomized controlled trials, as well as the unpublished and ongoing trials. We pooled the results using a random-effects model. RESULTS:We included seven studies with 770 randomized patients with dementia, which compared valproic acid with placebo. Indeed, there were no significant differences found in the scores of Mini-mental State Examination, Cohen-Mansfield Agitation Inventory and number of patients with adverse events. Valproic acid is generally well-tolerated in patients with dementia, even in long-term therapy for 24 months. CONCLUSION:Insufficient evidences are found to support valproic acid in the treatment of dementia for cognitive, psychiatric symptoms or disease-modifying. The anticipations for a success in the trial of valproic acid for dementia in the future look not optimistic based on the available evidence.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Liu J,Wang LNdoi
10.1016/j.archger.2020.104091subject
Has Abstractpub_date
2020-01-01 00:00:00pages
104091eissn
0167-4943issn
1872-6976pii
S0167-4943(20)30085-6journal_volume
89pub_type
杂志文章,meta分析abstract::Sleep is an active nervous process, which is structured in phases characterized by subsequent cycles of various psycho-physiological phenomena. It performs vital, yet mysterious functions and is in all likelihood involved in many processes, including cognitive processes. In old age the internal structure of sleep chan...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2007.01.054
更新日期:2007-01-01 00:00:00
abstract::There has been an extraordinary reversal in the perceived merits of sheltered housing. Once held up as the unquestioned solution to the housing needs of elderly people, it has now fallen under a cloud which has been referred to as a 'crisis of confidence'. This paper reassesses the contribution of research to the deba...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(91)90003-9
更新日期:1991-01-01 00:00:00
abstract::This study aimed to evaluate the physical frailty status of vulnerable older adults as classified in the Japanese LTCI system and to compare this with Fried's definition. A total of 444 older adults were classified based on the LTCI system as independent, vulnerable, or dependent, and 400 of these participants also fi...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2011.10.004
更新日期:2012-09-01 00:00:00
abstract::Twenty-three institutionalized subjects, confused and disoriented as to time, space and persons, were divided into two groups: the study group and the control group. The study group then participated in a 3-month period of formal Realithy Orientation Therapy (ROT). At the end of the 3 months of therapy significant dif...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(93)90052-j
更新日期:1993-11-01 00:00:00
abstract::Procedures for the estimation of the four parameters of a new mathematical model of survival and mortality kinetics are given. A formulation of the model has been found which had the advantage of maintaining three of four parameters independent of the unit chosen for the age; in addition, two of these parameters have ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(86)90015-4
更新日期:1986-07-01 00:00:00
abstract:AIMS:Type 2 Diabetes Mellitus(DM) is a well-known risk factor for cognitive impairment. Recent evidences suggest that Dipeptidyl peptidase-4(DPP-4) inhibitors might have neuroprotective effects. Therefore, this study aimed to investigate vildagliptin, a DPP-4 inhibitor, effects on cognitive function in older patients w...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2020.104013
更新日期:2020-01-01 00:00:00
abstract::Due to the difficulties in recruiting elderly people for psychological studies, a wide range of recruitment methods has been used. The underlying assumption that the recruitment method does not seriously affect the results has to be tested. Results in different worry measures are compared between three samples which w...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.archger.2007.09.009
更新日期:2009-01-01 00:00:00
abstract::This study quantified the monetary cost of family caregiving for 51 patients with different severity of dementia. The mean annual informal cost of care was higher (M=SG$44,530.55, SD=SG$31,354.82) compared to the mean annual formal cost of care (M=SG$25,654.11, SD=SG$10,016.48). Costs were found to increase with sever...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2017.03.006
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To design and validate a predictive BIA equation to estimate ASM in a sample of non-Caucasian older people and to explore the accuracy of two previous single-frequency BIA published equations. METHOD:This is a cross-sectional study in 213 physically-independent and apparently healthy older men and women subj...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2015.03.007
更新日期:2015-07-01 00:00:00
abstract::We have described twelve dementia patients with noise making. We categorized noise making into (i) persistent screaming, (ii) perseverative vocalization, (iii) continuous chattering, muttering, singing or humming, and (iv) swearing, grunting and bizarre noise-making. The patients' ages ranged from 70 to 92 years with ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(02)00169-3
更新日期:2003-05-01 00:00:00
abstract::Anemia is a common disease in elderly people. However, since hemoglobin concentration often decreases subclinically with aging because of nutritional impairment, its pathological significance is unclear. To investigate the pathological significance of low hemoglobin concentration, we studied the relation between hemog...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(98)00131-9
更新日期:1999-03-01 00:00:00
abstract::The respiratory burst stimuli zymosan, opsonized zymosan (OZ), or phorbol myristate acetate (PMA) were used in order to assess the ability of thioglycolate elicited peritoneal macrophages (PM) from young and senescent mice to generate superoxide anions. The amount of superoxide generated by PM from senescent mice in r...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(05)80020-2
更新日期:1992-01-01 00:00:00
abstract::There is evidence of an association of hypertension with white matter lesions (WMLs), leukoaraiosis, in the human brain in the United States, Europe and Japan. However, no study on this association has been reported in Korea. Community-dwelling elderly subjects aged over 61 years were randomly selected from samples of...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2004.09.003
更新日期:2005-05-01 00:00:00
abstract:INTRODUCTION:Sarcopenia is a geriatric syndrome characterized by loss of muscle mass and strength. The prevalence in people between 60-70 years is about 5-13% and in adults over 80 years, between 11-50% in the USA. Sarcopenia increases the risk of mortality and nosocomial infections. Community-acquired pneumonia is the...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2019.01.008
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Living alone may be associated with greater risk for social isolation and loneliness. Living alone, social isolation, loneliness, and limited engagement in social activity have all been associated with poorer cognitive function in later life. Hence, if individuals who live alone are also at greater risk of i...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2018.12.014
更新日期:2019-01-01 00:00:00
abstract::The present study was conducted to evaluate accuracy of a recently proposed method for estimating creatinine clearance (CLcr, ml/min) from actual body weight (ABW, kg), serum creatinine (Scr, micromol/l), and serum albumin (Alb, g/l) in elderly patients with muscle atrophy (the debilitated elderly). The recent method ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(97)00016-2
更新日期:1997-11-01 00:00:00
abstract::The calcium (Ca) antagonist flunarizine hydrochloride (FNZ) has been reported to induce parkinsonism, especially in the elderly. The effects of FNZ on dopamine receptors in rat striatal membranes, especially in aged rats, were studied using radiolabeled receptor assay. Similar displacing potencies in [(3)H]spiperone b...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(91)90049-v
更新日期:1991-11-01 00:00:00
abstract::Positional vertigo can be successfully treated by exercises (Vestibular Habituation Training, VHT) in elderly patients as well as in younger ones. Provided the patients have been correctly selected, this type of treatment is the only way for an adequate treatment of such a type of vertigo. Application of VHT has to be...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(89)90055-1
更新日期:1989-03-01 00:00:00
abstract::The changing social and economic conditions and the increase of the life span induced a progressive increase of the general prevalence of DMT2, particularly in the elderly population of the highly evoluted countries. Up to now 18 genetic loci have been identified, each of them consisting of several single nucleotide p...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,评审
doi:10.1016/j.archger.2010.06.017
更新日期:2011-07-01 00:00:00
abstract::One strategy to achieve coordination of care for older people with complex care needs is the establishment of shared care plans. The aim of this study was to explore the process of establishing a shared care plan from the perspective of elderly people and their next of kin. Data were collected via 12 semi-structured i...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2018.08.013
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Ageing is associated with increased morbidity, depression and decline in function. These may consequently impair the quality of life (QoL) of older adults. PURPOSE:This study was used to investigate the prevalence of functional disability, depression, and level of quality of life of older adults residing in...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2017.08.011
更新日期:2018-01-01 00:00:00
abstract::Achieving guideline-recommended blood pressure targets is difficult in older adults with hypertension. We completed a subgroup analysis of patients 65 years of age or older enrolled in PREVIEW, a prospective, multicenter, pharmacoepidemiological study of the determinants and outcomes of second-line antihypertensive tr...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2009.07.009
更新日期:2010-07-01 00:00:00
abstract::The elderly show a loss of both the intellectual functions and of motion ability. This happens also without particular pathologies; possible tests to highlight this loss are the Mini Mental State Examination (MMSE), and the Functional Reach (FR)-test. During 2004-2005 winter 50 healthy subjects were analyzed; the subj...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2011.04.008
更新日期:2012-01-01 00:00:00
abstract::Aging seems to be related to various vascular diseases, such as dissecting aneurysm and atherosclerosis. The nature of the relationship between aging and these vascular diseases has not been completely clarified. The goal of this study was to investigate, using morphological and morphometrical methods, the age related...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(93)90016-b
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:The phenomenon of empty-nest older adults has raised growing concerns in contemporary Chinese society. In this study, we examined the prevalence and related influencing factors of depression symptoms among empty-nest older adults in China at a national level. METHODS:The database of the 2015 China Health an...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2020.104183
更新日期:2020-07-21 00:00:00
abstract::Human figure drawings have been widely used to assess cognitive development in children. In the present study, free-hand human figure drawings were examined for 62 demented patients, and 60 normal elderly subjects. The drawings were scored for 53 body details using a method derived from work with children. A short sca...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(94)00567-2
更新日期:1994-11-01 00:00:00
abstract::In the elderly, folic acid deficiency may result in psychiatric symptoms or the increases in severity of other organic and non-organic mental diseases. We aimed to characterize elderly, community-dwelling, newly admitted patients to a large urban psychiatric hospital who are suffering from untreated folic acid deficie...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2005.04.006
更新日期:2005-11-01 00:00:00
abstract::The purpose of this study was to investigate how bladder management, rather than urinary incontinence, may affect the functional outcome of ischemic stroke patients. We studied 919 consecutive patients admitted for ischemic stroke rehabilitation. Level of bladder management was determined by Functional Independence Me...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2010.07.007
更新日期:2011-09-01 00:00:00
abstract::A study of the intracellular distribution of prion protein (PrP) in N2a neuroblastoma cells which had been infected with prions (ScN2a cells) revealed that most PrP is present in the cytoplasm. However, a significant amount of PrP is also present in the nucleus (predominantly in the nucleoli) of these cells, as analyz...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(96)00770-4
更新日期:1997-07-01 00:00:00
abstract::We sought to determine if low ANSS, usually associated with high pressure ulcer risk, are also associated with post-operative complications following spine fracture surgery in the elderly. This was a retrospective cross-sectional study conducted at the division of orthopedic surgery in a tertiary medical center betwee...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2011.08.007
更新日期:2012-07-01 00:00:00