Abstract：
INTRODUCTION:Delirium, a serious condition observed in critically ill patients, clinically presents with impaired cognition and consciousness. The relationship between delirium and peripheral levels of insulin growth factor-1 (IGF-1) is unclear. Thus we conducted a meta-analysis to address this issue. METHODS:Seven major electronic databases were searched from inception until October 2, 2017 to obtain relevant clinical variables to compare the difference in IGF-1 levels between delirious and non-delirious elderly in-patients. A random effects meta-analysis was conducted. RESULTS:We studies 10 articles involving 294 delirious patients (mean age 73.0 years) and 604 non-delirious patients (mean age 76.9 years). We found that peripheral levels of IGF-1 in patients with delirium were significantly lower than in those without delirium (Hedges' g = -0.209, 95% confidence interval [CI] = -0.393 to -0.026, p = 0.025). Meta-regression analyses found that no variables such as percentage of cognitive impairment, mean age, and female proportion contribute to heterogeneity in terms of the entire population. CONCLUSIONS:Our data suggests that lower peripheral levels of IGF-1 could be associated with a higher incidence of delirium among elderly patients. Further prospective studies with larger sample sizes are needed to investigate the association between peripheral levels of IGF-1 and delirium.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Li DJ,Tseng PT,Stubbs B,Chen TY,Lin PY,Chen SL,Thompson T,Adamis D,Chu CSdoi
10.1016/j.archger.2018.03.011subject
Has Abstractpub_date
2018-01-01 00:00:00pages
13-18eissn
0167-4943issn
1872-6976pii
S0167-4943(18)30047-5journal_volume
77pub_type
杂志文章,meta分析abstract：PURPOSE:To examine the association between WC and BMI on disability among older adults from LAC. METHODS:Cross-sectional, multicenter city study of 5786 subjects aged 65 years and older from the Health, Well-Being and Aging in Latin America and the Caribbean (SABE) study (1999-2000). Sociodemographic variables, smokin...
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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