Abstract：
:Brain transfer rate (BTR) and brain to plasma concentration ratio (BPCR) of radiolabelled human serum albumin injected intravenously were calculated to evaluate the brain transfer of serum albumin in the cerebral cortex, the right hemi-brain and the olfactory bulb of senescence accelerated prone mice (SAMP8) and senescence accelerated resistant mice (SAMR1). BTR and BPCR in SAMP8 and SAMR1 were significantly higher in the olfactory bulb than in the cerebral cortex or the right hemi-brain. Age-related significant changes in BTR and BPCR were observed in the olfactory bulb of SAMP8 and SAMR1. These findings suggest that the barrier function to serum albumin in the olfactory bulb of SAMP8 and SAMR1 is not so tight as it is in the cerebral cortex and becomes weaker with age and that the age-related changes are manifested at a younger age in SAMP8 than in SAMR1.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Ueno M,Akiguchi I,Hosokawa M,Shinnou M,Sakamoto H,Takemura M,Higuchi Kdoi
10.1016/s0167-4943(97)00022-8subject
Has Abstractpub_date
1997-11-01 00:00:00pages
321-31issue
3eissn
0167-4943issn
1872-6976pii
S0167-4943(97)00022-8journal_volume
25pub_type
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