Abstract：
:Hyperhomocysteinemia (HHcy) has been suggested as a predictive factor of cognitive alterations. Brazil has one of the highest aging dementia rates among the world's emerging countries. The objective of this study was to assess the influence of Hcy levels on the cognitive performance of low-income elderly. This cross-sectional study was developed in an urban center in the Northeast of Brazil and included 205 eligible community-dwelling older adults. A multidimensional questionnaire was used to evaluate sociodemographic aspects, health status and overall clinical aspects. Cognitive performance was assessed by the Portuguese version of Mini Mental State Examination (MMSE). Folic acid, vitamin B(12) and Hcy levels were determined by chemical luminescence. The association between sociodemographic variables, Hcy, serum vitamin B(12), folic acid levels and total MMSE score was assessed by multiple linear regression. Values indicative of HHcy (>12micromol/l) were found in 34.8% of the individuals. Age, schooling and HHcy showed a negative correlation with the MMSE score. The R(2) values of isolated HHcy explain only 4% of the MMSE score variance, however when associated to schooling and age, this model explained up to 25% of this association.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Tassino M,Campos TF,Guerra ROdoi
10.1016/j.archger.2007.12.002subject
Has Abstractpub_date
2009-03-01 00:00:00pages
142-5issue
2eissn
0167-4943issn
1872-6976pii
S0167-4943(07)00243-9journal_volume
48pub_type
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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更新日期：2010-01-01 00:00:00
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,多中心研究
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
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