Abstract：
:This study aimed to investigate the influence of apoE genetic polymorphism on serum lipid changes in a community-based elderly population in China in an 8-year period, in which 746 individual, aged 65.29 ± 6.85 years (mean ± standard deviation (SD)) were enrolled and serum lipid parameters were checked at baseline. After 8 years, serum lipids as well as apoE genotypes were measured. The frequencies of apoE allele were 9.4%, 81.7%, and 8.9% for ɛ2, ɛ3 and ɛ4, respectively. After the population was divided into 3 groups by different apoE allele carriers, the apoE allele carriers for ɛ2, ɛ3 and ɛ4 were 121 (16.2%), 513 (68.8%) and 112 (15.0%), respectively. Levels of total cholesterol (TC) and low density lipoprotein (LDL) in ɛ2 carriers were lower comparing with that of ɛ3 allele carriers at baseline. 8 years later, TC and high density lipoprotein (HDL) elevated and LDL decreased with aging in this population (p<0.01). The changes of TC levels were smaller in ɛ2 allele carriers as compared to that of ɛ3 allele carriers. The difference was still statistically significant after controlling for age, sex, smoking status, drinking habit, body mass index (BMI) and baseline TC level. The same trend of changes was noted for LDL between ɛ2 and ɛ3 allele carriers. However, no significant differences were noted between ɛ4 and ɛ3 allele carriers on lipid changes. This community-based study shows that ɛ2 allele is helpful on lipid changes. The effect of ɛ4 allele on lipid change is not strong in this elderly population. Genetic and environmental factors maybe co-operate on lipid metabolism in elderly persons.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Guan S,Yang J,Tang Z,Fang X,Wu X,Sun F,Liu H,Chan Pdoi
10.1016/j.archger.2011.12.001subject
Has Abstractpub_date
2012-11-01 00:00:00pages
713-7issue
3eissn
0167-4943issn
1872-6976pii
S0167-4943(11)00331-1journal_volume
55pub_type
杂志文章abstract：:Age-related changes of the hippocampal mossy fibre system were studied in rats of different ages (4, 12, and 24 months) using the Timm's histochemical technique for the detection of tissue stores of zinc and heavy transitional metals. Quantitative image analysis and microdensitometry techniques were applied for the ev...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(89)90071-x
更新日期：1989-01-01 00:00:00
abstract：:The epidemiologic data on smoking in association with Parkinson disease (PD) is puzzling. A lower incidence of smoking-related malignancies, especially lung cancer, has been reported by several studies in the patients with PD. In this study, we investigated polymorphic variations in the vascular endothelial growth fac...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2008.02.007
更新日期：2009-05-01 00:00:00
abstract：AIM:We aimed to compare diagnostic differences for identification of sarcopenia using the original operational definition developed by the European Working Group on Sarcopenia in Older People (EWGSOP1) and the most recently revised EWGSOP2 definition in community dwelling older adults with type 2 diabetes mellitus (T2D...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104081
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:With the aging phenomenon, there is growing interest in developing effective strategies to counteract dynapenia, the age-related loss of muscle strength. The positive effect of progressive resistance training on muscle strength is well known, however, the effect of nutritional supplementation or its synergis...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2020.104098
更新日期：2020-01-01 00:00:00
abstract：:The onset of delirium is frequent in elderly patients who sustain hip fractures. The purpose of this study was to characterize different patterns of preoperative and postoperative delirium, to study factors associated with preoperative delirium and to evaluate the possible different outcome of these patients. This ret...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(02)00058-4
更新日期：2003-01-01 00:00:00
abstract：:Depression is a major public health burden among the aging population. While older adults prefer non-pharmacological treatment, few options for psychotherapy are available in primary care settings, which is where older adults tend to receive mental health services. Indicated prevention is a cost-effective, public heal...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/j.archger.2012.03.003
更新日期：2012-11-01 00:00:00
abstract：:The effects of oxazepam on coordination and maximal seizure were compared between young (6-month-old) and old (24-month-old) BDF1 mice by using a rotorod test and a pentylenetetrazole (PTZ)-induced seizure test, respectively. The apparent sensitivity to oxazepam's anticonvulsant effect, as examined by its effect on PT...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/0167-4943(89)90022-8
更新日期：1989-07-01 00:00:00
abstract：:Behavioral and psychological signs of dementia (BPSD) are common clinical characteristics of Alzheimer's disease (AD). They result in patient and caregivers distress, decreased quality of life and placement in nursing homes. Treatment of BPSD with antidepressant and antipsychotic medications is not without complicatio...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00187-x
更新日期：2001-11-01 00:00:00
abstract：:Pregnancy and childbirth are an important physiological and emotional phenomenon in their lives for most women and studies have shown that this process may have a significant impact on their health at later ages. The objective of the study is to examine the relationship between functional disabilities in women over th...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2009.01.001
更新日期：2010-01-01 00:00:00
abstract：:The effect of food restriction on the survival characteristics, membrane microviscosity and proliferative response in lymphocytes of female Wistar undernourished rats has been evaluated. Diet restriction was applied starting from the age of 3.5 months by feeding the animals on an every-other-day schedule (EOD). Diet r...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(90)90001-m
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Falls in older adults, notably those with Alzheimer's dementia (AD), are prevalent. Vision and balance impairments are prominent falls risk factors in older adults. However, recent literature in the cognitively impaired suggests that executive function (EF) is important for falls risk assessments. The study ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104078
更新日期：2020-01-01 00:00:00
abstract：:We have described twelve dementia patients with noise making. We categorized noise making into (i) persistent screaming, (ii) perseverative vocalization, (iii) continuous chattering, muttering, singing or humming, and (iv) swearing, grunting and bizarre noise-making. The patients' ages ranged from 70 to 92 years with ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(02)00169-3
更新日期：2003-05-01 00:00:00
abstract：:Assessment of suffering is extremely important in dying end-stage dementia patients (ESDP). We have developed and examined the reliability and validity of the Mini-Suffering State Examination (MSSE), in 103 consecutive bedridden ESDP. Main outcome measures included inter-observer reliability and concurrent validity. R...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2003.08.007
更新日期：2004-03-01 00:00:00
abstract：:This study explored the association between vitamin D insufficiency and frailty syndrome defined by the Fried Frailty Index (FFI) and the Edmonton Frail Scale (EFS) in a northern Taiwan community. Data of 215 subjects participating in an integrated interventional trial involving community-dwelling older adults with a ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/S0167-4943(10)70006-6
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:As one of the leading causes of death around the world, suicide is a global public health threat. Due to the paucity of systematic studies, there exist vast variations in suicide ideation, attempts and suicide rates between various regions of Chinese aging communities. OBJECTIVES:Our systematic study aims t...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/j.archger.2013.05.006
更新日期：2013-11-01 00:00:00
abstract：:The cytotoxic activity of natural killer (NK) cells under both basal and interferon (IFN)-induced conditions, as well as the proliferative response of lymphocytes to ConA in old rats treated in vivo with AL-721 have been analyzed. The low levels of basal NK cell activity present in spleen of old rats were completely r...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(05)80030-5
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVES:This study aims to address whether associations between financial resources and self-perceived uselessness are different by urban-rural residence and whether the associations are stronger for subjectively-measured than for objectively-measured financial resources among older adults. DESIGN AND METHODS:We re...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2018.01.001
更新日期：2018-01-01 00:00:00
abstract：:Renal function is often altered in elderly patients. A lot of formulae are proposed to estimate GFR to adjust drug posology. French guidelines recommend the Cockcroft-Gault formula corrected with the body surface area (cCG), but the initially described unadjusted Cockcroft-Gault equation (CG) is mainly used in geriatr...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2009.05.010
更新日期：2010-05-01 00:00:00
abstract：:It is important to develop an accurate method of measuring controlled force exertion. This study examined the age differences between the controlled force exertion measured by a sinusoidal waveform and a bar chart display. The participants comprised 175 right-handed male adults aged 20-86 years. The participants were ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.02.002
更新日期：2013-07-01 00:00:00
abstract：AIM:This study aimed to compare the effects of two exercise programs on balance and risk of falls in older women with age-related visual dysfunction. METHODS:Participants living in a residential home were randomly allocated to Group I (n=21) receiving a progressive, tailored multimodal exercise program in addition to ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2012.01.009
更新日期：2012-09-01 00:00:00
abstract：:Hypothyroidism is a common disorder in older people, and may be asymptomatic and hard to be diagnosed. The main purpose of this study was to evaluate the distribution of serum thyrotropin (thyroxin-stimulating hormone, TSH) among asymptomatic older people in Taiwan, and to evaluate the relationship between age and ser...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2009.09.004
更新日期：2010-09-01 00:00:00
abstract：:Older adults with joint pain and comorbidity are especially at risk of becoming functionally impaired. Therefore, we studied the frequency and severity of functional limitations and identified potential modifiable determinants that may reduce functional limitations. A prospective cohort study of older adults (≥65 year...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2014.02.006
更新日期：2014-07-01 00:00:00
abstract：:The aim of this survey was to estimate the burden of antimicrobial use and to describe the determinants for antimicrobial use in Hungarian long-term care facilities (LTCFs) in order to increase the attention given to the proper prescription for this vulnerable population. A one-day point-prevalence study was undertake...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2014.02.011
更新日期：2014-07-01 00:00:00
abstract：:We aimed to examine the validity of fall risk assessment items for the healthy community-dwelling elderly Japanese population. Participants were 1122 healthy elderly individuals aged 60 years and over (380 males and 742 females). The percentage who had experienced a fall was 15.8%. This study used fall experience and ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.010
更新日期：2011-07-01 00:00:00
abstract：PURPOSE:Geriatric depression is now very common and leads to significant economic costs and family burden in China. Families with a depressed patient often report problematic family functioning in Western samples, and lack of social support is strongly associated with geriatric depression. However, the relationship bet...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2012.06.011
更新日期：2012-11-01 00:00:00
abstract：:Although otherwise extensively researched, one aspect of social functioning in older people that has received less attention is its association with staying at home for as long as possible. This 10-year follow-up examines factors of social functioning that support older people's independent living in their own homes a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2007.12.001
更新日期：2009-03-01 00:00:00
abstract：:The aim was to determine the validity and usefulness of hand-held dynamometry for measuring muscle strength in independent community-dwelling older persons. Cross-sectional study was performed in 281 subjects aged over 65, mean age of 74.3 years. The strength of six muscle groups was measured in three consecutive atte...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.02.006
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVES:This study explored the associations of empty nest and group activity with cognitive impairment in Chinese older adults. MATERIALS AND METHODS:Data were analyzed from 10,349 participants of the second-round survey database of the Zhejiang Ageing and Health Cohort Study aged 60 years and over. Cognitive impa...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104120
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:To design and validate a predictive BIA equation to estimate ASM in a sample of non-Caucasian older people and to explore the accuracy of two previous single-frequency BIA published equations. METHOD:This is a cross-sectional study in 213 physically-independent and apparently healthy older men and women subj...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.03.007
更新日期：2015-07-01 00:00:00
abstract：:Motor dysfunction increases in the moderate and severe stages of dementia. However, there is still no consensus on changes in mobility during its early stages. This meta-analysis aimed to measure the level of single-task functional mobility in older subjects with mild cognitive impairment (MCI) and/or Alzheimer's dise...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,meta分析
doi：10.1016/j.archger.2019.103941
更新日期：2019-01-01 00:00:00
