Food restriction in female Wistar rats. I. Survival characteristics, membrane microviscosity and proliferative response in lymphocytes.

Abstract:

:The effect of food restriction on the survival characteristics, membrane microviscosity and proliferative response in lymphocytes of female Wistar undernourished rats has been evaluated. Diet restriction was applied starting from the age of 3.5 months by feeding the animals on an every-other-day schedule (EOD). Diet restricted animals showed an increase of both mean, median and maximal life span as compared to the rats fed ad libitum (AL). Analyzing the survival curves by a parametric model, it emerged that undernutrition increased the individual resistance to environmental insults. In particular, it could be speculated that the positive influence was more pronounced in individuals with the lowest physiological capacities. The membrane microviscosity of lymphocytes was lower in EOD animals as compared to the AL ones even if one assumes a decrease in body temperature of 1-2 degrees C in EOD groups. The improvement of membrane microviscosity due to diet restriction may in part explain the improvement of proliferative response of lymphocytes from EOD groups.

journal_name

Arch Gerontol Geriatr

authors

Pieri C,Recchioni R,Moroni F,Marcheselli F,Falasca M,Piantanelli L

doi

10.1016/0167-4943(90)90001-m

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

99-108

issue

2

eissn

0167-4943

issn

1872-6976

pii

016749439090001M

journal_volume

11

pub_type

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