当前位置： SCI文献检索 > ARCHIVES OF GERONTOLOGY AND GERIATRICS期刊下所有文献 > Carvedilol in elderly patients with chronic heart failure, a 12 weeks randomized, placebo controlled open trial.

Carvedilol in elderly patients with chronic heart failure, a 12 weeks randomized, placebo controlled open trial.

Abstract：

:The encouraging results of recent multicenter clinical trials conducted in the US on the effect of carvedilol therapy in patients with chronic heart failure, prompted us to verify its tolerability in a group of elderly patients. For the open, randomized, placebo-controlled study, we selected 40 patients (28 men and 12 women, mean age 76.8+/-5.9 years) with mild, moderate or severe chronic heart failure. Exclusion criteria included dementia, chronic hepatitis, renal failure, severe vascular disease and respiratory failure. All patients were receiving treatment with digitalis, furosemide and ACE inhibitors. The study lasted 12 weeks. During the first week, all subjects received oral placebo or carvedilol, at a dose of 6.25 mg twice daily. The twice daily dose was then increased to 12.5 mg during weeks 2-4 and to 25 mg from weeks 5-12. At 0, after the 2 weeks of run-in, 4 and 12 weeks patients underwent assessment of systolic and diastolic blood pressure, heart rate, left ventricular ejection fraction, cognitive status and functional ability. Our findings indicate that elderly patients with congestive heart failure tolerate carvedilol therapy well. Carvedilol slightly improves heart function without altering functional or cognitive ability. A larger-scale trial in geriatric patients is now required to determine whether this treatment will reduce serious morbidity or mortality from heart failure.

journal_name

Arch Gerontol Geriatr

journal_title

Archives of gerontology and geriatrics

authors

Leonetti Luparini R,Celli V,Piccirillo G,Guidi V,Cacciafesta M,Marigliano V

doi

10.1016/s0167-4943(99)00040-0

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

275-82

issue

3

eissn

0167-4943

issn

1872-6976

pii

S0167494399000400

journal_volume

29

pub_type

临床试验,杂志文章,随机对照试验

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