Tricyclic antidepressant and cardiovascular drug interactions.

Abstract:

:Tricyclic antidepressants have anticholinergic, adrenolytic and quinidine-like activity. These actions result in a variety of cardiac and blood pressure effects. Tricyclic antidepressants can reverse the antihypertensive effect of guanethidine and clonidine. Orthostatic hypotension may be increased with diuretics and hydralazine. Myocardial depression may occur with lidocaine, phenytoin or propranolol. Dangerous additive effects may result from concomitant use of a tricyclic antidepressant and either quinidine or procainamide.

journal_name

Am Fam Physician

authors

Thornton WE

subject

Has Abstract

pub_date

1979-07-01 00:00:00

pages

97-9

issue

1

eissn

0002-838X

issn

1532-0650

journal_volume

20

pub_type

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