Abstract：
:A drug delivery system which provides a sustained release of norethindrone (NET) and mestranol (ME) for one month after a single intramuscular injection was assessed as a long-acting injectable contraceptive. The system is based upon well defined particle size crystals of the synthetic steroids maintained in suspension with saline solution. Eight healthy ovulating women volunteered for the study; they received a combination of 10 mg of NET plus 1 mg of ME in 1 ml of vehicle by intramuscular injection on day five of their menstrual cycle. Blood samples were drawn at 0, 1, 5, 10, 13, 17 and 21 days after drug administration. The immunoreactive serum levels of estradiol, progesterone, NET and ethinylestradiol were measured by specific radioimmunoassay procedures to assess ovarian function and the kinetic parameters of the synthetic steroids. This newly developed contraceptive system proved to be both effective, and long-lasting as well as devoid of side effects.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Díaz-Sánchez V,Garza-Flores J,Jimenéz-Thomas S,Rudel HWdoi
10.1016/0010-7824(87)90051-5subject
Has Abstractpub_date
1987-01-01 00:00:00pages
57-68issue
1eissn
0010-7824issn
1879-0518pii
0010-7824(87)90051-5journal_volume
35pub_type
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