Abstract:
:Proteins are chief actors in life that perform a myriad of exquisite functions. This diversity has been enabled through the evolution and diversification of protein folds. Analysis of sequences and structures strongly suggest that numerous protein pieces have been reused as building blocks and propagated to many modern folds. This information can be traced to understand how the protein world has diversified. In this review, we discuss the latest advances in the analysis of protein evolutionary units, and we use as a model system one of the most abundant and versatile topologies, the TIM-barrel fold, to highlight the existing common principles that interconnect protein evolution, structure, folding, function, and design.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Romero-Romero S,Kordes S,Michel F,Höcker Bdoi
10.1016/j.sbi.2020.12.007subject
Has Abstractpub_date
2021-01-13 00:00:00pages
94-104eissn
0959-440Xissn
1879-033Xpii
S0959-440X(20)30224-4journal_volume
68pub_type
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journal_title:Current opinion in structural biology
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