Physical basis of a protein-DNA recognition code.

Abstract:

:Can a stereochemical recognition code explain sequence-specific protein-nucleic acid interactions? Whereas a code that is generally applicable to DNA-binding proteins of all known structural families is unattainable, the indications are that a code can describe at least some of the interactions of classical zinc fingers with DNA. The crystal structures of related zinc finger-DNA complexes reveal a remarkable mode of interaction that sets the framework for this code, and recent biochemical studies have elucidated the intermolecular contacts (contingent on this framework) that result in specificity.

journal_name

Curr Opin Struct Biol

authors

Choo Y,Klug A

doi

10.1016/s0959-440x(97)80015-2

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

117-25

issue

1

eissn

0959-440X

issn

1879-033X

pii

S0959-440X(97)80015-2

journal_volume

7

pub_type

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