当前位置： SCI文献检索 > ENVIRONMENT INTERNATIONAL期刊下所有文献 > EFSA's OpenFoodTox: An open source toxicological database on chemicals in food and feed and its future developments.

EFSA's OpenFoodTox: An open source toxicological database on chemicals in food and feed and its future developments.

Abstract：

:Since its creation in 2002, the European Food Safety Authority (EFSA) has produced risk assessments for over 5000 substances in >2000 Scientific Opinions, Statements and Conclusions through the work of its Scientific Panels, Units and Scientific Committee. OpenFoodTox is an open source toxicological database, available both for download and data visualisation which provides data for all substances evaluated by EFSA including substance characterisation, links to EFSA's outputs, applicable legislations regulations, and a summary of hazard identification and hazard characterisation data for human health, animal health and ecological assessments. The database has been structured using OECD harmonised templates for reporting chemical test summaries (OHTs) to facilitate data sharing with stakeholders with an interest in chemical risk assessment, such as sister agencies, international scientific advisory bodies, and others. This manuscript provides a description of OpenFoodTox including data model, content and tools to download and search the database. Examples of applications of OpenFoodTox in chemical risk assessment are discussed including new quantitative structure-activity relationship (QSAR) models, integration into tools (OECD QSAR Toolbox and AMBIT-2.0), assessment of environmental footprints and testing of threshold of toxicological concern (TTC) values for food related compounds. Finally, future developments for OpenFoodTox 2.0 include the integration of new properties, such as physico-chemical properties, exposure data, toxicokinetic information; and the future integration within in silico modelling platforms such as QSAR models and physiologically-based kinetic models. Such structured in vivo, in vitro and in silico hazard data provide different lines of evidence which can be assembled, weighed and integrated using harmonised Weight of Evidence approaches to support the use of New Approach Methodologies (NAMs) in chemical risk assessment and the reduction of animal testing.

journal_name

Environ Int

journal_title

Environment international

authors

Dorne JLCM,Richardson J,Livaniou A,Carnesecchi E,Ceriani L,Baldin R,Kovarich S,Pavan M,Saouter E,Biganzoli F,Pasinato L,Zare Jeddi M,Robinson TP,Kass GEN,Liem AKD,Toropov AA,Toropova AP,Yang C,Tarkhov A,Georgiadis N

doi

10.1016/j.envint.2020.106293

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

106293

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(20)32248-0

journal_volume

146

pub_type

杂志文章,评审

相关文献

ENVIRONMENT INTERNATIONAL文献大全
  • Prenatal particulate air pollution and neurodevelopment in urban children: Examining sensitive windows and sex-specific associations.

    abstract：BACKGROUND:Brain growth and structural organization occurs in stages beginning prenatally. Toxicants may impact neurodevelopment differently dependent upon exposure timing and fetal sex. OBJECTIVES:We implemented innovative methodology to identify sensitive windows for the associations between prenatal particulate mat...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2015.11.010

    authors： Chiu YH,Hsu HH,Coull BA,Bellinger DC,Kloog I,Schwartz J,Wright RO,Wright RJ

    更新日期：2016-02-01 00:00:00

  • A state-of-the-art model for spatial and stochastic oil spill risk assessment: A case study of oil spill from a shipwreck.

    abstract：:Oil spills are serious environmental issues that potentially can cause adverse effects on marine ecosystems. In some marine areas, like the Baltic Sea, there is a large number of wrecks from the first half of the 20th century, and recent monitoring and field work have revealed release of oil from some of these wrecks....

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.02.037

    authors： Amir-Heidari P,Arneborg L,Lindgren JF,Lindhe A,Rosén L,Raie M,Axell L,Hassellöv IM

    更新日期：2019-05-01 00:00:00

  • Potential interactions between syntrophic bacteria and methanogens via type IV pili and quorum-sensing systems.

    abstract：:Interspecies electron transfer plays an important role in syntrophic methanogenesis. Direct interspecies electron transfer (DIET) between syntrophic oxidizers and methanogens via conductive pili has been only confirmed in some specific co-cultures. This study examined potential syntrophic cooperation via type IV pili ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105650

    authors： Yin Q,Gu M,Hermanowicz SW,Hu H,Wu G

    更新日期：2020-05-01 00:00:00

  • Preliminary measurements of aromatic VOCs in public transportation modes in Guangzhou, China.

    abstract：:This study examined the exposure level of aromatic volatile organic compounds (VOCs) in public transportation modes in Guangzhou, China. A total of 40 VOC samples were conducted in four popular public commuting modes (subway, taxis, non-air-conditioned buses and air-conditioned buses) while traversing in urban areas o...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/S0160-4120(02)00189-7

    authors： Chan LY,Lau WL,Wang XM,Tang JH

    更新日期：2003-07-01 00:00:00

  • Association of prenatal pesticide exposures with adverse pregnancy outcomes and stunting in rural Bangladesh.

    abstract：BACKGROUND:Pesticide exposure during pregnancy is thought to adversely affect fetal growth, which in turn may impact child growth, but results have been inconsistent across studies and few have explored these effects in developing countries. OBJECTIVES:To quantify urinary concentrations of pesticide biomarkers in earl...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.105243

    authors： Jaacks LM,Diao N,Calafat AM,Ospina M,Mazumdar M,Ibne Hasan MOS,Wright R,Quamruzzaman Q,Christiani DC

    更新日期：2019-12-01 00:00:00

  • Impact of climate change on human infectious diseases: Empirical evidence and human adaptation.

    abstract：:Climate change refers to long-term shifts in weather conditions and patterns of extreme weather events. It may lead to changes in health threat to human beings, multiplying existing health problems. This review examines the scientific evidences on the impact of climate change on human infectious diseases. It identifie...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2015.09.007

    authors： Wu X,Lu Y,Zhou S,Chen L,Xu B

    更新日期：2016-01-01 00:00:00

  • Dietary exposure to neonicotinoid insecticides and health risks in the Chinese general population through two consecutive total diet studies.

    abstract：:Neonicotinoid insecticides are ubiquitous in food and the environment due to their wide use. Growing evidence suggests the adverse effects of neonicotinoids in many species, including mammals. Some studies have reported the urinary concentrations of neonicotinoids in human biological monitoring, but the potential risk...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.105399

    authors： Chen D,Zhang Y,Lv B,Liu Z,Han J,Li J,Zhao Y,Wu Y

    更新日期：2020-02-01 00:00:00

  • Rapid determination of the electroporation threshold for bacteria inactivation using a lab-on-a-chip platform.

    abstract：:Electroporation based locally enhanced electric field treatment (LEEFT) is an emerging bacteria inactivation technology for drinking water disinfection. Nevertheless, the lethal electroporation threshold (LET) for bacteria has not been studied, partly due to the tedious work required by traditional experimental method...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.105040

    authors： Wang T,Chen H,Yu C,Xie X

    更新日期：2019-11-01 00:00:00

  • Understanding the systemic nature of cities to improve health and climate change mitigation.

    abstract：:Understanding cities comprehensively as systems is a costly challenge and is typically not feasible for policy makers. Nevertheless, focusing on some key systemic characteristics of cities can give useful insights for policy to advance health and well-being outcomes. Moreover, if we take a coevolutionary systems view ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2016.04.014

    authors： Chapman R,Howden-Chapman P,Capon A

    更新日期：2016-09-01 00:00:00

  • Health burdens of surface ozone in the UK for a range of future scenarios.

    abstract：:Exposure to surface ozone (O3), which is influenced by emissions of precursor chemical species, meteorology and population distribution, is associated with excess mortality and respiratory morbidity. In this study, the EMEP-WRF atmospheric chemistry transport model was used to simulate surface O3 concentrations at 5km...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2013.09.010

    authors： Heal MR,Heaviside C,Doherty RM,Vieno M,Stevenson DS,Vardoulakis S

    更新日期：2013-11-01 00:00:00

  • Toxicological effects in children exposed to lead: A cross-sectional study at the Colombian Caribbean coast.

    abstract：:Lead (Pb) is an environmental pollutant with a toxicity that is a serious public health problem. The aim of this research was to evaluate the associations between Pb exposure and morphometric, hematological and biochemical parameters, mRNA expression of the P53, SOD1, ALAD, TNF and INF-γ genes, ALAD polymorphisms (db ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.05.003

    authors： Alvarez-Ortega N,Caballero-Gallardo K,Olivero-Verbel J

    更新日期：2019-09-01 00:00:00

  • Birth outcomes associated with maternal exposure to metals from informal electronic waste recycling in Guiyu, China.

    abstract：BACKGROUND:Informal electronic waste (e-waste) recycling is a rapidly growing industry. Informal e-waste recycling creates a mixture of chemicals that can be harmful to humans, especially vulnerable populations like pregnant women and young children. OBJECTIVES:We aimed to analyze the associations between birth outcom...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105580

    authors： Kim SS,Xu X,Zhang Y,Zheng X,Liu R,Dietrich KN,Reponen T,Xie C,Sucharew H,Huo X,Chen A

    更新日期：2020-04-01 00:00:00

  • Burden of cause-specific mortality attributable to heat and cold: A multicity time-series study in Jiangsu Province, China.

    abstract：:Previous epidemiological studies primarily examined the temperature-related mortality burden of all-cause or cardiovascular diseases (CVD) and respiratory diseases. However, evidence on the heat- and cold-attributable mortality burden from other specific causes is limited. This paper aimed to systematically examine th...

    journal_title：Environment international

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.envint.2020.105994

    authors： Ma Y,Zhou L,Chen K

    更新日期：2020-11-01 00:00:00

  • Managing mass casualties and decontamination.

    abstract：:Careful planning and regular exercising of capabilities is the key to implementing an effective response following the release of hazardous materials, although ad hoc changes may be inevitable. Critical actions which require immediate implementation at an incident are evacuation, followed by disrobing (removal of clot...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2014.02.006

    authors： Chilcott RP

    更新日期：2014-11-01 00:00:00

  • Investigation of polycyclic aromatic hydrocarbon level in blood and semen quality for residents in Pearl River Delta Region in China.

    abstract：:This study is the first one investigating the correlation between the concentration of polycyclic aromatic hydrocarbon (PAHs) in blood and semen qualities for residents in the Pearl River Delta (PRD) region in China. Blood samples from 53 infertile volunteers were studied for measures of semen quality and 16 PAHs. Inf...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2013.08.003

    authors： Song XF,Chen ZY,Zang ZJ,Zhang YN,Zeng F,Peng YP,Yang C

    更新日期：2013-10-01 00:00:00

  • Antibiotic-manufacturing sites are hot-spots for the release and spread of antibiotic resistance genes and mobile genetic elements in receiving aquatic environments.

    abstract：:High antibiotic releases from manufacturing facilities have been identified as a risk factor for antibiotic resistance development in bacterial pathogens. However, the role of antibiotic pollution in selection and transferability of antibiotic resistance genes (ARGs) is still limited. In this study, we analyzed efflue...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.04.007

    authors： González-Plaza JJ,Blau K,Milaković M,Jurina T,Smalla K,Udiković-Kolić N

    更新日期：2019-09-01 00:00:00

  • Health risks from large-scale water pollution: trends in Central Asia.

    abstract：:Limited data on the pollution status of spatially extensive water systems constrain health-risk assessments at basin-scales. Using a recipient measurement approach in a terminal water body, we show that agricultural and industrial pollutants in groundwater-surface water systems of the Aral Sea Drainage Basin (covering...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2010.11.006

    authors： Törnqvist R,Jarsjö J,Karimov B

    更新日期：2011-02-01 00:00:00

  • The impact of flood and post-flood cleaning on airborne microbiological and particle contamination in residential houses.

    abstract：:In January 2011, Brisbane, Australia, experienced a major river flooding event. We aimed to investigate its effects on air quality and assess the role of prompt cleaning activities in reducing the airborne exposure risk. A comprehensive, multi-parameter indoor and outdoor measurement campaign was conducted in 41 resid...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2014.04.001

    authors： He C,Salonen H,Ling X,Crilley L,Jayasundara N,Cheung HC,Hargreaves M,Huygens F,Knibbs LD,Ayoko GA,Morawska L

    更新日期：2014-08-01 00:00:00

  • Acute effects of ambient temperature on hypotension hospital visits: A time-series analysis in seven metropolitan cities of Korea from 2011 to 2015.

    abstract：BACKGROUND:Although blood pressure decreases in response to high ambient temperature, little is known about whether the ambient temperature can induce clinical hypotension events. Therefore, we conducted a time-series analysis to evaluate the association between hypotension hospital visits and ambient temperature in se...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.104941

    authors： Han C,Lim YH,Lee KS,Hong YC

    更新日期：2019-10-01 00:00:00

  • Phytoremediation potential of twelve wild plant species for toxic elements in a contaminated soil.

    abstract：:Green remediation of soils highly contaminated with potentially toxic elements (PTEs) can be achieved using suitable plants. Such phytoremediation procedure often takes into consideration PTE concentrations in plants only, but not produced biomass. Phytoremediation potential of certain species of wild plants for PTEs ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.106233

    authors： Antoniadis V,Shaheen SM,Stärk HJ,Wennrich R,Levizou E,Merbach I,Rinklebe J

    更新日期：2021-01-01 00:00:00

  • Predominance of BDE-209 and other higher brominated diphenyl ethers in eggs of white stork (Ciconia ciconia) colonies from Spain.

    abstract：:Polybrominated diphenyl ethers (PBDEs) are ubiquitous pollutants for which there is still a lack of knowledge about the environmental behavior and fate of the higher brominated congeners (octa- to deca-BDEs). In this study, the PBDE content and congener profiles in failed eggs from two colonies of white stork (Ciconia...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2010.11.013

    authors： Muñoz-Arnanz J,Sáez M,Aguirre JI,Hiraldo F,Baos R,Pacepavicius G,Alaee M,Jiménez B

    更新日期：2011-04-01 00:00:00

  • Antibiotic resistance genes are increased by combined exposure to sulfamethoxazole and naproxen but relieved by low-salinity.

    abstract：:Combined pollution of antibiotic and non-antibiotic pharmaceutical residues is ubiquitous in realistic polluted environments, which is regarded as a complicated emerging pollution. Herein, high-throughput sequencing and high-throughput quantitative PCR were applied to profile the overall changes in microbial communiti...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105742

    authors： Yan W,Bai R,Wang S,Tian X,Li Y,Wang S,Yang F,Xiao Y,Lu X,Zhao F

    更新日期：2020-06-01 00:00:00

  • Associations between ultrafine and fine particles and mortality in five central European cities - Results from the UFIREG study.

    abstract：BACKGROUND:Evidence on health effects of ultrafine particles (UFP) is still limited as they are usually not monitored routinely. The few epidemiological studies on UFP and (cause-specific) mortality so far have reported inconsistent results. OBJECTIVES:The main objective of the UFIREG project was to investigate the sh...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2015.12.006

    authors： Lanzinger S,Schneider A,Breitner S,Stafoggia M,Erzen I,Dostal M,Pastorkova A,Bastian S,Cyrys J,Zscheppang A,Kolodnitska T,Peters A,UFIREG study group.

    更新日期：2016-03-01 00:00:00

  • Predicting CO2 and SO2 emissions in the Baltic States through reorganization of energy infrastructure.

    abstract：:The paper deals with predicting carbon dioxide and sulphur dioxide emissions generated by power production sector in the Baltic States in period up to year 2020. The economies of Lithuania, Latvia and Estonia are rapidly growing therefore forecast of emissions related with this occurrence becomes very important. The I...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2004.05.004

    authors： Denafas G,Sitnikovas D,Galinis A,Kudrenickis I,Klavs G,Kuusik R

    更新日期：2004-10-01 00:00:00

  • Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study.

    abstract：BACKGROUND:Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs during the perinatal period have not been investigated. OBJECTIVE...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.105139

    authors： Itoh S,Araki A,Miyashita C,Yamazaki K,Goudarzi H,Minatoya M,Ait Bamai Y,Kobayashi S,Okada E,Kashino I,Yuasa M,Baba T,Kishi R

    更新日期：2019-12-01 00:00:00

  • Effects of environmental factors on the seasonally change of phytoplankton populations in a closed freshwater pond.

    abstract：:The effect of environmental factors affecting the population dynamic of phytoplankton population was studied seasonally in a closed freshwater pond with the natural water of Lake Kasumigaura, Japan. The predominant phytoplankton species in the pond were classified as Oscillatoria tenuis, Synedra ulna, Chlamydomonas ci...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/s0160-4120(01)00087-3

    authors： Alam MG,Jahan N,Thalib L,Wei B,Maekawa T

    更新日期：2001-11-01 00:00:00

  • Thallium: a review of public health and environmental concerns.

    abstract：:Thallium (Tl) is a rare but widely dispersed element. All forms of thallium are soluble enough to be toxic to living organisms. Thallium is more toxic to humans than mercury, cadmium, lead, copper or zinc and has been responsible for many accidental, occupational, deliberate, and therapeutic poisonings since its disco...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2004.09.003

    authors： Peter AL,Viraraghavan T

    更新日期：2005-05-01 00:00:00

  • Wearable camera-derived microenvironments in relation to personal exposure to PM2.5.

    abstract：:Data regarding which microenvironments drive exposure to air pollution in low and middle income countries are scarce. Our objective was to identify sources of time-resolved personal PM2.5 exposure in peri-urban India using wearable camera-derived microenvironmental information. We conducted a panel study with up to 6 ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2018.05.021

    authors： Salmon M,Milà C,Bhogadi S,Addanki S,Madhira P,Muddepaka N,Mora A,Sanchez M,Kinra S,Sreekanth V,Doherty A,Marshall JD,Tonne C

    更新日期：2018-08-01 00:00:00

  • Can commercial low-cost sensor platforms contribute to air quality monitoring and exposure estimates?

    abstract：:The emergence of low-cost, user-friendly and very compact air pollution platforms enable observations at high spatial resolution in near-real-time and provide new opportunities to simultaneously enhance existing monitoring systems, as well as engage citizens in active environmental monitoring. This provides a whole ne...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2016.12.007

    authors： Castell N,Dauge FR,Schneider P,Vogt M,Lerner U,Fishbain B,Broday D,Bartonova A

    更新日期：2017-02-01 00:00:00

  • The role of environmental factors in the spatial distribution of Japanese encephalitis in mainland China.

    abstract：:Japanese encephalitis (JE) is the most common cause of viral encephalitis and an important public health concern in the Asia-Pacific region, particularly in China where 50% of global cases are notified. To explore the association between environmental factors and human JE cases and identify the high risk areas for JE ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2014.07.004

    authors： Wang L,Hu W,Soares Magalhaes RJ,Bi P,Ding F,Sun H,Li S,Yin W,Wei L,Liu Q,Haque U,Sun Y,Huang L,Tong S,Clements AC,Zhang W,Li C

    更新日期：2014-12-01 00:00:00