当前位置： SCI文献检索 > ENVIRONMENT INTERNATIONAL期刊下所有文献 > Toxicological effects in children exposed to lead: A cross-sectional study at the Colombian Caribbean coast.

Toxicological effects in children exposed to lead: A cross-sectional study at the Colombian Caribbean coast.

Abstract：

:Lead (Pb) is an environmental pollutant with a toxicity that is a serious public health problem. The aim of this research was to evaluate the associations between Pb exposure and morphometric, hematological and biochemical parameters, mRNA expression of the P53, SOD1, ALAD, TNF and INF-γ genes, ALAD polymorphisms (db SNP ID: rs1800435) and Intelligence Quotient (IQ) in children from the Colombian Caribbean. Blood lead levels (BLL) were determined in 554 participants between the ages of 5-16 years old, from different places of the Colombian Caribbean. A health survey was given to assess risk factors. Whole blood was used for hematology and plasma employed to analyze markers of hepatic toxicity. Gene expression was quantified from blood mRNA by RT-PCR. The ALAD polymorphism was characterized by PCR-RFLP, and the Kaufman's brief intelligence test was employed to estimate the IQ. The mean BLL was 3.5 ± 0.2 μg/dL. The site of greatest exposure to Pb was Tasajera, a poor fishing community, with an average of 8.9 ± 0.8 μg/dL. Breastfeeding was associated with high BLL. Morphometric characteristics and IQ were negatively correlated with BLL. The blood platelet count and the mean corpuscular hemoglobin concentration showed positive and negative correlations with BLL, respectively. Negative relationships with BLL were observed with the ratios Neutrophils/Eosinophils and Neutrophils/Basophils, whereas for BLL and Neutrophils/Monocytes the association was positive. The associations between morphometric and some hematological parameters with BLL were age- and gender-related. The expression of ALAD, SOD1, INF-γ and P53 mRNA was down-regulated according to the BLL, whereas TNF showed an opposite trend. In short, fishing communities are at a high risk of Pb exposure. This xenobiotic can affect physical development and IQ, as well as hematological parameters, even at low concentrations. In addition, it can regulate the transcription of genes associated with inflammation, apoptosis, cell cycle, heme synthesis, and oxidative stress.

journal_name

Environ Int

journal_title

Environment international

authors

Alvarez-Ortega N,Caballero-Gallardo K,Olivero-Verbel J

doi

10.1016/j.envint.2019.05.003

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

104809

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(19)30689-0

journal_volume

130

pub_type

杂志文章

相关文献

ENVIRONMENT INTERNATIONAL文献大全
  • Volatile organic compounds in indoor environment and photocatalytic oxidation: state of the art.

    abstract：:Volatile organic compounds (VOCs) are the major pollutants in indoor air, which significantly impact indoor air quality and thus influencing human health. A long-term exposure to VOCs will be detrimental to human health causing sick building syndrome (SBS). Photocatalytic oxidation of VOCs is a cost-effective technolo...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2007.02.011

    authors： Wang S,Ang HM,Tade MO

    更新日期：2007-07-01 00:00:00

  • Ecological and spatial factors drive intra- and interspecific variation in exposure of subarctic predatory bird nestlings to persistent organic pollutants.

    abstract：:Top predators in northern ecosystems may suffer from exposure to persistent organic pollutants (POPs) as this exposure may synergistically interact with already elevated natural stress in these ecosystems. In the present study, we aimed at identifying biological (sex, body condition), ecological (dietary carbon source...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2013.03.009

    authors： Eulaers I,Jaspers VL,Bustnes JO,Covaci A,Johnsen TV,Halley DJ,Moum T,Ims RA,Hanssen SA,Erikstad KE,Herzke D,Sonne C,Ballesteros M,Pinxten R,Eens M

    更新日期：2013-07-01 00:00:00

  • Dietary exposure to neonicotinoid insecticides and health risks in the Chinese general population through two consecutive total diet studies.

    abstract：:Neonicotinoid insecticides are ubiquitous in food and the environment due to their wide use. Growing evidence suggests the adverse effects of neonicotinoids in many species, including mammals. Some studies have reported the urinary concentrations of neonicotinoids in human biological monitoring, but the potential risk...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.105399

    authors： Chen D,Zhang Y,Lv B,Liu Z,Han J,Li J,Zhao Y,Wu Y

    更新日期：2020-02-01 00:00:00

  • National monitoring of PCDD/DFs in environmental media around incinerators in Korea.

    abstract：:To examine the levels of PCDD/DFs pollution in environmental samples in the vicinity of various incinerators, the levels of PCDD/DFs in air and soil samples collected near 17 incinerators and stack emission gases were investigated between 2003 and 2006. A total of 434 soil, 28 stack emission gas, and 38 air samples we...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2007.08.002

    authors： Kim KS,Shin SK,Kim KS,Song BJ,Kim JG

    更新日期：2008-02-01 00:00:00

  • Replacing fish meal by food waste in feed pellets to culture lower trophic level fish containing acceptable levels of organochlorine pesticides: health risk assessments.

    abstract：:The present study used food waste (collected from local hotels and restaurants) feed pellets in polyculture of low-trophic level fish [bighead (Aristichtys nobilis), grass carp (Ctenopharyngodon idellus), and mud carp (Cirrhina molitorella)] aiming at producing safe and quality products for local consumption. The resu...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2014.07.001

    authors： Cheng Z,Mo WY,Man YB,Nie XP,Li KB,Wong MH

    更新日期：2014-12-01 00:00:00

  • Spatial variations in the levels and isomeric patterns of PBDEs and HBCDs in the European eel in Flanders.

    abstract：:Pooled yellow eel (Anguilla anguilla L.) samples, consisting of 3-10 eels, from 50 locations collected in the period 2000-2006 were used to assess the pollution with PBDEs and HBCDs in Flemish waters (Belgium). Results from this monitoring network are presented and the spatial aspect throughout Flanders is included, l...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2010.03.001

    authors： Roosens L,Geeraerts C,Belpaire C,Van Pelt I,Neels H,Covaci A

    更新日期：2010-07-01 00:00:00

  • Remediation of mercury contaminated soil, water, and air: A review of emerging materials and innovative technologies.

    abstract：:Mercury contamination in soil, water and air is associated with potential toxicity to humans and ecosystems. Industrial activities such as coal combustion have led to increased mercury (Hg) concentrations in different environmental media. This review critically evaluates recent developments in technological approaches...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2019.105281

    authors： Wang L,Hou D,Cao Y,Ok YS,Tack FMG,Rinklebe J,O'Connor D

    更新日期：2020-01-01 00:00:00

  • Efficiency of the activated carbon filtration in the natural organic matter removal.

    abstract：:The removal and transformation of natural organic matter were monitored in the different stages of the drinking water treatment train. Several methods to measure the quantity and quality of organic matter were used. The full-scale treatment sequence consisted of coagulation, flocculation, clarification by flotation, d...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2005.06.003

    authors： Matilainen A,Vieno N,Tuhkanen T

    更新日期：2006-04-01 00:00:00

  • Identification of environmental sources of lead exposure in Nunavut (Canada) using stable isotope analyses.

    abstract：BACKGROUND:Blood lead levels (BLLs) were measured in the adult Inuit population of Nunavut, Northern Canada, during the Inuit Health Survey (IHS) in 2007-2008. Approximately 10% of the adult participants had BLL over the Health Canada's guidance of 100μg/L. OBJECTIVES:1) To repeat the measurement of BLL among the IHS ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2014.06.004

    authors： Fillion M,Blais JM,Yumvihoze E,Nakajima M,Workman P,Osborne G,Chan HM

    更新日期：2014-10-01 00:00:00

  • Associations between serum perfluoroalkyl acids and LINE-1 DNA methylation.

    abstract：:Perfluoroalkyl acids (PFAAs) are persistent, synthetic compounds that are used in a number of consumer products. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) have been associated with cardiovascular risk factors, and changes in gene expression and DNA methylation in animals and cellular systems. ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2013.10.018

    authors： Watkins DJ,Wellenius GA,Butler RA,Bartell SM,Fletcher T,Kelsey KT

    更新日期：2014-02-01 00:00:00

  • Nature and origin of multicomponent aerial emissions of the copper-nickel smelter complex.

    abstract：:The Severonickel Smelter Complex as well as other big nickel-copper smelter plants are the source of metallurgical dust emissions, enriched with toxic elements Ni, Cu, Pb, Zn and As. The phase composition of typical metallurgy dust is described as pentlandite (Ni,Fe)9S8, pyrrhotite Fe7S8(Ni(x)), chalcopyrite CuFeS2, c...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/s0160-4120(02)00064-8

    authors： Barcan V

    更新日期：2002-12-01 00:00:00

  • Arsenic mobilization from iron oxyhydroxides is regulated by organic matter carbon to nitrogen (C:N) ratio.

    abstract：:Arsenic (As) is mobilized from delta and floodplain aquifer sediments throughout S.E. Asia via reductive dissolution of As bound to iron (Fe) oxyhydroxides. The reductive driving force is organic carbon, but its source and constitution is uncertain. Here batch incubation experiments were conducted to investigate the r...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2008.07.024

    authors： Solaiman AR,Meharg AA,Gault AG,Charnock JM

    更新日期：2009-04-01 00:00:00

  • Critical factors in assessing exposure to PBDEs via house dust.

    abstract：:Assessment of indoor exposure to polybrominated diphenyl ethers (PBDEs) requires a critical examination of methods that may influence exposure estimates and comparisons between studies. We measured PBDEs in residential dust collected from 20 homes in Boston, MA, to examine 5 key questions: 1) Does the choice of dust e...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2008.03.006

    authors： Allen JG,McClean MD,Stapleton HM,Webster TF

    更新日期：2008-11-01 00:00:00

  • Quantitative bias analysis of the association of type 2 diabetes mellitus with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153).

    abstract：:An association between serum concentrations of persistent organic pollutants (POPs), such as 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), and risk of type 2 diabetes mellitus (T2DM) has been reported. Conditional on body mass index (BMI) and waist circumference (WC), a higher serum PCB-153 concentration may be a marke...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2018.12.036

    authors： Dzierlenga MW,Yoon M,Wania F,Ward PL,Armitage JM,Wood SA,Clewell HJ,Longnecker MP

    更新日期：2019-04-01 00:00:00

  • Endocrine disrupting compounds in drinking water supply system and human health risk implication.

    abstract：:To date, experimental and epidemiological evidence of endocrine disrupting compounds (EDCs) adversely affecting human and animal populations has been widely debated. Notably, human health risk assessment is required for risk mitigation. The lack of human health risk assessment and management may thus unreliably regula...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2017.05.004

    authors： Wee SY,Aris AZ

    更新日期：2017-09-01 00:00:00

  • Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy.

    abstract：:Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to air pollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL in maternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately af...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.106202

    authors： Harnung Scholten R,Møller P,Jovanovic Andersen Z,Dehlendorff C,Khan J,Brandt J,Ketzel M,Knudsen LE,Mathiesen L

    更新日期：2021-01-01 00:00:00

  • Plasticenta: First evidence of microplastics in human placenta.

    abstract：:Microplastics are particles smaller than five millimeters deriving from the degradation of plastic objects present in the environment. Microplastics can move from the environment to living organisms, including mammals. In this study, six human placentas, collected from consenting women with physiological pregnancies, ...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2020.106274

    authors： Ragusa A,Svelato A,Santacroce C,Catalano P,Notarstefano V,Carnevali O,Papa F,Rongioletti MCA,Baiocco F,Draghi S,D'Amore E,Rinaldo D,Matta M,Giorgini E

    更新日期：2021-01-01 00:00:00

  • Association of maternal serum copper during early pregnancy with the risk of spontaneous preterm birth: A nested case-control study in China.

    abstract：BACKGROUND:The effect of maternal copper (Cu) level on the risk of spontaneous preterm birth (SPB) remains debate. Therefore, we conducted a prospective nested case-control study in Shanxi Province to investigate the relationship between maternal serum Cu concentration and SPB risk, as well as the potential mediation e...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2018.11.009

    authors： Hao Y,Pang Y,Yan H,Zhang Y,Liu J,Jin L,Yan L,Chen D,Hu L,Liu Q,Qin Y,Wang B,Li Z,Ye R,Zhang L,Ren A

    更新日期：2019-01-01 00:00:00

  • Assessment of persistent toxic substances in the environment of Egypt.

    abstract：:The objective of this review is to provide a comprehensive assessment of the threats posed by persistent toxic substances (PTS) to the environment and human health in Egypt and to identify priorities, data gaps and recommendations for future intervention to control, reduce or eliminate releases of PTS. Data on availab...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/S0160-4120(03)00181-8

    authors： Barakat AO

    更新日期：2004-05-01 00:00:00

  • EFSA's OpenFoodTox: An open source toxicological database on chemicals in food and feed and its future developments.

    abstract：:Since its creation in 2002, the European Food Safety Authority (EFSA) has produced risk assessments for over 5000 substances in >2000 Scientific Opinions, Statements and Conclusions through the work of its Scientific Panels, Units and Scientific Committee. OpenFoodTox is an open source toxicological database, availabl...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2020.106293

    authors： Dorne JLCM,Richardson J,Livaniou A,Carnesecchi E,Ceriani L,Baldin R,Kovarich S,Pavan M,Saouter E,Biganzoli F,Pasinato L,Zare Jeddi M,Robinson TP,Kass GEN,Liem AKD,Toropov AA,Toropova AP,Yang C,Tarkhov A,Georgiadis N

    更新日期：2021-01-01 00:00:00

  • Biomagnification of naturally-produced methoxylated polybrominated diphenyl ethers (MeO-PBDEs) in harbour seals and harbour porpoises from the southern North Sea.

    abstract：:Harbour seals and harbour porpoises are top predator species from the North Sea, have long life spans and hence, are known to accumulate high levels of anthropogenic contaminants. To gain knowledge about the behaviour of naturally-produced compounds in these marine mammals, the biomagnification of naturally-produced m...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2009.03.006

    authors： Weijs L,Losada S,Das K,Roosens L,Reijnders PJ,Santos JF,Neels H,Blust R,Covaci A

    更新日期：2009-08-01 00:00:00

  • Maternal urinary cadmium concentrations in relation to preterm birth in the Healthy Baby Cohort Study in China.

    abstract：BACKGROUND:Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. The aim of this study was to evaluate the association between prenatal Cd exposure and birth outcomes. METHODS:This study was conducted in 5364 pregnant women with a live si...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2016.06.003

    authors： Yang J,Huo W,Zhang B,Zheng T,Li Y,Pan X,Liu W,Chang H,Jiang M,Zhou A,Qian Z,Wan Y,Xia W,Xu S

    更新日期：2016-09-01 00:00:00

  • Particle size: a missing factor in risk assessment of human exposure to toxic chemicals in settled indoor dust.

    abstract：:For researches on toxic chemicals in settled indoor dust, selection of dust fraction is a critical influencing factor to the accuracy of human exposure risk assessment results. However, analysis of the selection of dust fraction in recent studies revealed that there is no consensus. This study classified and presented...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2012.08.010

    authors： Cao ZG,Yu G,Chen YS,Cao QM,Fiedler H,Deng SB,Huang J,Wang B

    更新日期：2012-11-15 00:00:00

  • Weather and gastrointestinal disease in Spain: A retrospective time series regression study.

    abstract：BACKGROUND:A few studies in high-income countries have investigated the relationship between ambient temperature and/or precipitation and the occurrence of gastroenteritis. In most of the cases, hot temperatures and heavy precipitation events have been related to increases in infections. This is of concern as climate c...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2018.10.003

    authors： Morral-Puigmal C,Martínez-Solanas È,Villanueva CM,Basagaña X

    更新日期：2018-12-01 00:00:00

  • Human exposure to endocrine disrupting chemicals and fertility: A case-control study in male subfertility patients.

    abstract：BACKGROUND:Dioxins, PCBs, chlorinated pesticides, brominated flame retardants, bisphenol A, triclosan, perfluorinated compounds and phthalates are known as endocrine disrupting chemicals (EDCs). OBJECTIVES:The aim of our study was to investigate whether higher exposure to EDCs is associated with increased subfertility...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2015.07.017

    authors： Den Hond E,Tournaye H,De Sutter P,Ombelet W,Baeyens W,Covaci A,Cox B,Nawrot TS,Van Larebeke N,D'Hooghe T

    更新日期：2015-11-01 00:00:00

  • Superior nitrogen-doped activated carbon materials for water cleaning and energy storing prepared from renewable leather wastes.

    abstract：:The fabrication of nitrogen-doped activated carbons (N-ACs) from leather solid wastes (LSW), a huge underutilized bioresource, by different activation methods was investigated. N-AC prepared by KOH activation (named KNAC) exhibited superior physical and chemical properties with much higher BET surface area (2247 m2 g-...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105846

    authors： Han W,Wang H,Xia K,Chen S,Yan P,Deng T,Zhu W

    更新日期：2020-09-01 00:00:00

  • A review on organophosphate Ester (OPE) flame retardants and plasticizers in foodstuffs: Levels, distribution, human dietary exposure, and future directions.

    abstract：:Given the ongoing studies on the adverse effects of organophosphate ester (OPE) flame retardants and plasticizers on human health, there is an increasing scientific interest in the risk of exposure to OPEs via dietary intake. Using peer-reviewed literature published up to 2018, this review surveyed and compiled the av...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2019.03.009

    authors： Li J,Zhao L,Letcher RJ,Zhang Y,Jian K,Zhang J,Su G

    更新日期：2019-06-01 00:00:00

  • Using deep learning to examine street view green and blue spaces and their associations with geriatric depression in Beijing, China.

    abstract：BACKGROUND:Residential green and blue spaces may be therapeutic for the mental health. However, solid evidence on the linkage between exposure to green and blue spaces and mental health among the elderly in non-Western countries is scarce and limited to exposure metrics based on remote sensing images (i.e., land cover ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.02.013

    authors： Helbich M,Yao Y,Liu Y,Zhang J,Liu P,Wang R

    更新日期：2019-05-01 00:00:00

  • Habitat function of agricultural soils as affected by heavy metals and polycyclic aromatic hydrocarbons contamination.

    abstract：:Ecotoxic activity of soils polluted with polycyclic aromatic hydrocarbon (PAH) and heavy metals (HM) was evaluated in pot and laboratory experiments. Plants and soil microorganisms were chosen as test organisms and six different soil materials were used in the study. The applied levels of HM and PAH were aimed to refl...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/S0160-4120(02)00117-4

    authors： Maliszewska-Kordybach B,Smreczak B

    更新日期：2003-03-01 00:00:00

  • Risk perception and access to environmental information in four areas in Italy affected by natural or anthropogenic pollution.

    abstract：:A human biomonitoring (HBM) survey in four areas affected by natural or anthropogenic arsenic pollution was conducted in Italy within the framework of the SEpiAs project. A questionnaire, including the exploration of risk perception (RP) regarding environmental hazards and access to and trust in information, was admin...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2016.07.009

    authors： Coi A,Minichilli F,Bustaffa E,Carone S,Santoro M,Bianchi F,Cori L

    更新日期：2016-10-01 00:00:00