Correlation of cefoxitin MICs with the presence of mecA in Staphylococcus spp.

Abstract:

:This report describes the results of an 11-laboratory study to determine if a cefoxitin broth microdilution MIC test could predict the presence of mecA in staphylococci. Using breakpoints of < or = 4 microg/ml for mecA-negative and > or = 6 or 8 microg/ml for mecA-positive isolates, sensitivity and specificity based on mecA or presumed mecA for Staphylococcus aureus at 18 h of incubation were 99.7 to 100% in three cation-adjusted Mueller-Hinton broths tested. For coagulase-negative strains at 24 h of incubation, breakpoints of < or = 2 microg/ml for mecA-negative and > or = 4 microg/ml for mecA-positive isolates gave sensitivity and specificity of 94 to 99% and 69 to 80%, respectively.

journal_name

J Clin Microbiol

authors

Swenson JM,Brasso WB,Ferraro MJ,Hardy DJ,Knapp CC,Lonsway D,McAllister S,Reller LB,Sader HS,Shortridge D,Skov R,Weinstein MP,Zimmer BL,Patel JB

doi

10.1128/JCM.02304-08

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

1902-5

issue

6

eissn

0095-1137

issn

1098-660X

pii

JCM.02304-08

journal_volume

47

pub_type

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