Fungal pleural effusion secondary to a rare cause of pancreatic pseudocyst.

Abstract:

:We report a case of fungal pleural effusion secondary to presumed valproate induced pancreatitis with pseudocyst and stricture formation. A child with dyskinetic cerebral palsy who had been on sodium valproate for several years was transferred for drainage of a left sided pleural effusion. Pleural fluid culture consistently grew Candida glabrata although the patient was treated with broad-spectrum antibiotic and antifungal therapy. Clinical deterioration ensued with abdominal discomfort, feed intolerance, and re-accumulation of the effusion. Investigations revealed a large pancreatic pseudocyst compressing the stomach and impairing pancreatic function. Subsequent therapeutic evacuation of pancreatic fluid demonstrated C. glabrata. This case underscores that pleural disease may be secondary to abdominal pathology, and always to consider rare side-effects of medication in the face of a puzzling clinical picture.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Gupta A,Marrs T,Urquhart D,Clarke S,Rosenthal M,Bush A

doi

10.1002/ppul.20982

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

616-8

issue

6

eissn

8755-6863

issn

1099-0496

journal_volume

44

pub_type

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