Abstract:
:The principal hydroxy-metabolites of benzene--hydroquinone, catechol and phenol--were assayed in tests for mitotic segregation induction in Aspergillus nidulans diploid strain 19. Hydroquinone was the most effective chemical, increasing the frequency of mitotic segregants up to 10-fold at 1-3 mM. Catechol was similarly active at 10-20 mM and phenol was weakly positive at 15 mM. Genetic characterization of induced abnormal segregating colonies by replating and complementary assays with haploid strain 35 suggest that gross chromosomal aberrations, instead of numerical abnormalities, are the primary genetic damages induced by hydroxybenzenes in A. nidulans. The protecting activity exerted by L-cysteine against equimolar concentrations of hydroquinone supports a free radical mechanism for hydroxybenzenes genotoxicity in A. nidulans.
journal_name
Mutagenesisjournal_title
Mutagenesisauthors
Crebelli R,Conti G,Carere Adoi
10.1093/mutage/2.3.235subject
Has Abstractpub_date
1987-05-01 00:00:00pages
235-8issue
3eissn
0267-8357issn
1464-3804journal_volume
2pub_type
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