Citric acid bioproduction and downstream processing: Status, opportunities, and challenges.

Abstract:

:Citric acid (CA) has been widely used in different industrial sectors, being produced through fermentation of low-cost feedstock. The development of downstream processes, easier to operate, environmentally friendly, and more economic than precipitation, is certainly a challenge in CA bioproduction. Large volumes of by-products generated in precipitation require treatment before disposal. Adsorption, extraction, and membrane separation have been shown to have a lower environmental impact than precipitation, but the technological maturity of these methods is still limited. However, reactive extraction and adsorption have great potential for industrial applications. This review shows that there is still much to be explored, both about the factors that are intrinsic to the techniques, but also in their combination for new processes' development. This review reports the most recent advances on CA bioproduction, with significant information about recovery and purification methods involving this highly industrially demanded organic acid.

journal_name

Bioresour Technol

journal_title

Bioresource technology

authors

Mores S,Vandenberghe LPS,Magalhães Júnior AI,de Carvalho JC,de Mello AFM,Pandey A,Soccol CR

doi

10.1016/j.biortech.2020.124426

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

124426

issue

Pt B

eissn

0960-8524

issn

1873-2976

pii

S0960-8524(20)31700-4

journal_volume

320

pub_type

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